scholarly journals Selective catalytic amination of halogenated aldehydes with calcined palladium catalysts

RSC Advances ◽  
2018 ◽  
Vol 8 (27) ◽  
pp. 15202-15206
Author(s):  
Alberto Villa ◽  
Kim Dumoleijn ◽  
Claudio Evangelisti ◽  
Kristof Moonen ◽  
Laura Prati
Keyword(s):  
Palladium Catalysts ◽  
Reductive Amination ◽  
Calcination Step ◽  
Catalytic Amination

This work focuses on understanding the influence of the conditions used in the calcination step of palladium catalysts on the performance of this catalyst in the reductive amination of halogen-containing substrates.

ChemInform Abstract: Reductive Amination of Furfurol with Aromatic Amines on Palladium Catalysts.

ChemInform ◽  
2010 ◽  
Vol 26 (18) ◽  
pp. no-no
Author(s):  
M. V. KLYUEV ◽  
A. A. NASIBULIN ◽  
M. G. ABDULLAEV
Keyword(s):  
Aromatic Amines ◽  
Palladium Catalysts ◽  
Reductive Amination

Stable Preformed Chiral Palladium Catalysts for the One-Pot Asymmetric Reductive Amination of Ketones

2009 ◽  
Vol 11 (2) ◽  
pp. 265-268 ◽  
Author(s):  
Laura Rubio-Pérez ◽  
F. Javier Pérez-Flores ◽  
Pankaj Sharma ◽  
Luis Velasco ◽  
Armando Cabrera
Keyword(s):  
Palladium Catalysts ◽  
Reductive Amination ◽  
One Pot ◽  
The One

ChemInform Abstract: Stable Preformed Chiral Palladium Catalysts for the One-Pot Asymmetric Reductive Amination of Ketones.

ChemInform ◽  
2009 ◽  
Vol 40 (24) ◽  
Author(s):  
Laura Rubio-Perez ◽  
F. Javier Perez-Flores ◽  
Pankaj Sharma ◽  
Luis Velasco ◽  
Armando Cabrera
Keyword(s):  
Palladium Catalysts ◽  
Reductive Amination ◽  
One Pot ◽  
The One

Selective Functionalization at N2-Position of Guanine in Oligonucleotides via Reductive Amination

2020 ◽  
Author(s):  
Bapurao Bhoge ◽  
Ishu Saraogi
Keyword(s):  
Organic Chemistry ◽  
Chemical Biology ◽  
Reductive Amination ◽  
The Other ◽  
Dna Oligomers ◽  
Site Specific ◽  
Wide Applicability ◽  
Dna Oligonucleotides ◽  
Selective Functionalization

Chemo- and site-specific modifications in oligonucleotides have wide applicability as mechanistic probes in chemical biology. Here we have employed a classical reaction in organic chemistry, reductive amination, to selectively functionalize the N<sup>2</sup>-amine of guanine/2’-deoxyguanine monophosphate. This method specifically modifies guanine in several tested DNA oligonucleotides, while leaving the other bases unaffected. Using this approach, we have successfully incorporated desired handles chemoselectively into DNA oligomers.

Bringing Biocatalysis into the Deuteration Toolbox

2019 ◽  
Author(s):  
Jack Rowbotham ◽  
Oliver Lenz ◽  
Holly Reeve ◽  
Kylie Vincent
Keyword(s):  
Late Stage ◽  
Hydrogen Isotope ◽  
Reductive Amination ◽  
Mechanistic Studies ◽  
Ambient Conditions ◽  
Synthetic Pathway ◽  
Drug Candidates ◽  
Isotopic Selectivity ◽  
Reducing Equivalents

<p></p><p>Chemicals labelled with the heavy hydrogen isotope deuterium (<sup>2</sup>H) have long been used in chemical and biochemical mechanistic studies, spectroscopy, and as analytical tracers. More recently, demonstration of selectively deuterated drug candidates that exhibit advantageous pharmacological traits has spurred innovations in metal-catalysed <sup>2</sup>H insertion at targeted sites, but asymmetric deuteration remains a key challenge. Here we demonstrate an easy-to-implement biocatalytic deuteration strategy, achieving high chemo-, enantio- and isotopic selectivity, requiring only <sup>2</sup>H<sub>2</sub>O (D<sub>2</sub>O) and unlabelled dihydrogen under ambient conditions. The vast library of enzymes established for NADH-dependent C=O, C=C, and C=N bond reductions have yet to appear in the toolbox of commonly employed <sup>2</sup>H-labelling techniques due to requirements for suitable deuterated reducing equivalents. By facilitating transfer of deuterium atoms from <sup>2</sup>H<sub>2</sub>O solvent to NAD<sup>+</sup>, with H<sub>2</sub> gas as a clean reductant, we open up biocatalysis for asymmetric reductive deuteration as part of a synthetic pathway or in late stage functionalisation. We demonstrate enantioselective deuteration via ketone and alkene reductions and reductive amination, as well as exquisite chemo-control for deuteration of compounds with multiple unsaturated sites.</p><p></p>

Recent Advances in Reductive Amination Catalysis and Its Applications

2015 ◽  
Vol 19 (11) ◽  
pp. 1021-1049 ◽  
Author(s):  
Heshmatollah Alinezhad ◽  
Hossein Yavari ◽  
Fatemeh Salehian
Keyword(s):  
Reductive Amination ◽  
Recent Advances

Model reactions for the study of hydrogenation and acidic activity of palladium catalysts

1987 ◽  
Vol 52 (8) ◽  
pp. 2019-2027 ◽  
Author(s):  
Libor Červený ◽  
Nguyen Thi Du ◽  
Ivo Paseka
Keyword(s):  
Palladium Catalysts ◽  
Styrene Oxide ◽  
Side Reactions ◽  
Pd Catalysts ◽  
Variable Parameters ◽  
Acid Properties ◽  
Liquid Phase Hydrogenation ◽  
Acid Catalysed Reactions ◽  
Different Content ◽  
Model Reactions

Palladium catalysts have been used to study the hydrogenation of 1-phenyl-2-butene-1-ol which is accompanied by several side reactions considered to be acid-catalysed. Another model reaction studied was dehydration and subsequent hydrogenation or hydrogenolysis of 1-phenyl-1,3-propanediol to 3-phenyl-1-propanol, accompanied by formation of propylbenzene. The dehydration and propylbenzene formation can be again classified as acid-catalysed reactions. Another one is methanolysis of styrene oxide taking place under conditions of liquid phase hydrogenation due to the acid properties of Pd-H systems. Hydrogenation activity of Pd catalysts was tested by hydrogenation of cyclohexene. Sixteen Pd catalysts on different supports and with different content of active component were used, their activity and selectivity was determined and the effect of variable parameters in the synthesis of these catalysts on the activity and selectivity is discussed.

Sign in / Sign up

Export Citation Format

Share Document