scholarly journals Preparation of poly(lactic acid)/graphene oxide nanofiber membranes with different structures by electrospinning for drug delivery

RSC Advances ◽  
2018 ◽  
Vol 8 (30) ◽  
pp. 16619-16625 ◽  
Author(s):  
Zhou Mao ◽  
Jialiang Li ◽  
Wenjie Huang ◽  
Hao Jiang ◽  
Bhahat Lawlley Zimba ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Drug Delivery ◽  
Graphene Oxide ◽  
Lactic Acid ◽  
Poly Lactic Acid ◽  
Burst Release ◽  
Nanofiber Membrane ◽  
Initial Burst ◽  
Nanofiber Membranes ◽  
Sheath Structure

PLA/GO nanofiber membrane with the co-axial structure exhibited the improved mechanical properties, which is also beneficial to separately loading different drugs in core-/sheath-structure and suppressing the initial burst release of drugs.

Emulsion electrospun polylactic acid/Apocynum venetum nanocellulose nanofiber membranes with controlled sea buckthorn extract release as a drug delivery system

2020 ◽  
pp. 004051752097017
Author(s):  
Lu Wang ◽  
Chenmeizi Wang ◽  
Ling Wang ◽  
Qingle Zhang ◽  
Ying Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polylactic Acid ◽  
Encapsulation Efficiency ◽  
Sea Buckthorn ◽  
Burst Release ◽  
Nanofiber Membrane ◽  
Apocynum Venetum ◽  
Nanofiber Membranes ◽  
Sheath Structure

Prolonging the duration of drug action and reducing toxicity play a vital role in wound administration as they reduce the chance of infection and decrease complications and cost. This study reports the natural antioxidant procyanidins extracted from sea buckthorn (SBT) and laboratory-manufactured Apocynum venetum cellulose nanofiber as core drugs. The sustained-release nanofiber membrane was prepared by electrospinning on polylactic acid/polyvinyl pyrrolidone nanofibers. High-performance liquid chromatography-mass spectrometry was used to identify the phenolic compounds in SBT extracts and confirmed the presence of procyanidins with a content of 0.0345 mg/g. The nanofiber membrane was characterized through transmission electron microscopy, encapsulation efficiency, in vitro drug-release study and antioxidant assay. The results indicated that the extracted procyanidins were successfully encapsulated in the core–sheath structure nanofibers, and the encapsulation efficiency of nanofiber membranes reached 83.84%. In vitro measurements of the delivery showed this core–sheath structure could significantly alleviate the drug burst release, which is followed by a linear and smooth release within 30 hours. Further tests showed that the removal efficiency of 2,2-diphenyl-1-picrylhydrazyl reached 88.62%, indicating that the membranes had high antioxidant activity. This work implies that the combination of Apocynum venetum nanocellulose and emulsion electrospun fibers has promising potential applications in tissue engineering or drug delivery.

scholarly journals Drug Delivery Applications of Core-Sheath Nanofibers Prepared by Coaxial Electrospinning: A Review

Pharmaceutics ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 305 ◽  
Author(s):  
Bishweshwar Pant ◽  
Mira Park ◽  
Soo-Jin Park
Keyword(s):  
Drug Delivery ◽  
Electrospun Nanofibers ◽  
Coaxial Electrospinning ◽  
Burst Release ◽  
High Porosity ◽  
Nanofiber Membrane ◽  
Initial Burst ◽  
Initial Burst Release ◽  
Small Pore ◽  
Drug Delivery Applications

Electrospinning has emerged as one of the potential techniques for producing nanofibers. The use of electrospun nanofibers in drug delivery has increased rapidly over recent years due to their valuable properties, which include a large surface area, high porosity, small pore size, superior mechanical properties, and ease of surface modification. A drug loaded nanofiber membrane can be prepared via electrospinning using a model drug and polymer solution; however, the release of the drug from the nanofiber membrane in a safe and controlled way is challenging as a result of the initial burst release. Employing a core-sheath design provides a promising solution for controlling the initial burst release. Numerous studies have reported on the preparation of core-sheath nanofibers by coaxial electrospinning for drug delivery applications. This paper summarizes the physical phenomena, the effects of various parameters in coaxial electrospinning, and the usefulness of core-sheath nanofibers in drug delivery. Furthermore, this report also highlights the future challenges involved in utilizing core-sheath nanofibers for drug delivery applications.

scholarly journals Novel electrospun poly(lactic acid)/poly(butylene carbonate)/graphene oxide nanofiber membranes for antibacterial applications

AIP Advances ◽  
2019 ◽  
Vol 9 (6) ◽  
pp. 065315
Author(s):  
Xiaohua Gu ◽  
Yan Li ◽  
Rui Cao ◽  
Siwen Liu ◽  
Congzhi Fu ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Lactic Acid ◽  
Poly Lactic Acid ◽  
Nanofiber Membranes

Drug delivery systems using sandwich configurations of electrospun poly(lactic acid) nanofiber membranes and ibuprofen

2013 ◽  
Vol 33 (7) ◽  
pp. 4002-4008 ◽  
Author(s):  
Ana Paula Serafini Immich ◽  
Manuel Lis Arias ◽  
Núria Carreras ◽  
Rafael Luís Boemo ◽  
José Antonio Tornero
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Poly Lactic Acid ◽  
Nanofiber Membranes

scholarly journals Electrically Triggered Drug Delivery from Novel Electrospun Poly(Lactic Acid)/Graphene Oxide/Quercetin Fibrous Scaffolds for Wound Dressing Applications

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 957
Author(s):  
Alexa-Maria Croitoru ◽  
Yasin Karaçelebi ◽  
Elif Saatcioglu ◽  
Eray Altan ◽  
Songul Ulag ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Lactic Acid ◽  
Wound Dressing ◽  
Film Growth ◽  
In Vitro Release ◽  
Chemical Properties ◽  
Poly Lactic Acid ◽  
Fibroblast Cells

The novel controlled and localized delivery of drug molecules to target tissues using an external electric stimulus makes electro-responsive drug delivery systems both feasible and desirable, as well as entailing a reduction in the side effects. Novel micro-scaffold matrices were designed based on poly(lactic acid) (PLA) and graphene oxide (GO) via electrospinning. Quercetin (Q), a natural flavonoid, was loaded into the fiber matrices in order to investigate the potential as a model drug for wound dressing applications. The physico-chemical properties, electrical triggering capacity, antimicrobial assay and biocompatibility were also investigated. The newly fabricated PLA/GO/Q scaffolds showed uniform and smooth surface morphologies, without any beads, and with diameters ranging from 1107 nm (10%PLA/0.1GO/Q) to 1243 nm (10%PLA). The in vitro release tests of Q from the scaffolds showed that Q can be released much faster (up to 8640 times) when an appropriate electric field is applied compared to traditional drug-release approaches. For instance, 10 s of electric stimulation is enough to ensure the full delivery of the loaded Q from the 10%PLA/1%GO/Q microfiber scaffold at both 10 Hz and at 50 Hz. The antimicrobial tests showed the inhibition of bacterial film growth. Certainly, these materials could be loaded with more potent agents for anti-cancer, anti-infection, and anti-osteoporotic therapies. The L929 fibroblast cells cultured on these scaffolds were distributed homogeneously on the scaffolds, and the highest viability value of 82.3% was obtained for the 10%PLA/0.5%GO/Q microfiber scaffold. Moreover, the addition of Q in the PLA/GO matrix stimulated the production of IL-6 at 24 h, which could be linked to an acute inflammatory response in the exposed fibroblast cells, as a potential effect of wound healing. As a general conclusion, these results demonstrate the possibility of developing graphene oxide-based supports for the electrically triggered delivery of biological active agents, with the delivery rate being externally controlled in order to ensure personalized release.

Conductivity and mechanical properties of carbon black-reinforced poly(lactic acid) (PLA/CB) composites

2021 ◽  
Author(s):  
Jipeng Guo ◽  
Chi-Hui Tsou ◽  
Yongqi Yu ◽  
Chin-San Wu ◽  
Xuemei Zhang ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Lactic Acid ◽  
Carbon Black ◽  
Poly Lactic Acid

scholarly journals A Review: Research Progress in Modification of Poly (Lactic Acid) by Lignin and Cellulose

Polymers ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 776
Author(s):  
Sixiang Zhai ◽  
Qingying Liu ◽  
Yuelong Zhao ◽  
Hui Sun ◽  
Biao Yang ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Lactic Acid ◽  
Composite Materials ◽  
Crystallization Rate ◽  
Research Progress ◽  
Poly Lactic Acid ◽  
Green Composite ◽  
Materials Development ◽  
Research Attention ◽  
Biomass Components

With the depletion of petroleum energy, the possibility of prices of petroleum-based materials increasing, and increased environmental awareness, biodegradable materials as a kind of green alternative have attracted more and more research attention. In this context, poly (lactic acid) has shown a unique combination of properties such as nontoxicity, biodegradability, biocompatibility, and good workability. However, examples of its known drawbacks include poor tensile strength, low elongation at break, poor thermal properties, and low crystallization rate. Lignocellulosic materials such as lignin and cellulose have excellent biodegradability and mechanical properties. Compounding such biomass components with poly (lactic acid) is expected to prepare green composite materials with improved properties of poly (lactic acid). This paper is aimed at summarizing the research progress of modification of poly (lactic acid) with lignin and cellulose made in in recent years, with emphasis on effects of lignin and cellulose on mechanical properties, thermal stability and crystallinity on poly (lactic acid) composite materials. Development of poly (lactic acid) composite materials in this respect is forecasted.

scholarly journals Mechanical Properties and Bioactivity of Poly(Lactic Acid) Composites Containing Poly(Glycolic Acid) Fiber and Hydroxyapatite Particles

Nanomaterials ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 249
Author(s):  
Han-Seung Ko ◽  
Sangwoon Lee ◽  
Doyoung Lee ◽  
Jae Young Jho
Keyword(s):  
Mechanical Properties ◽  
Lactic Acid ◽  
Flexural Strength ◽  
Interfacial Adhesion ◽  
Glycolic Acid ◽  
Compact Bone ◽  
Poly Lactic Acid ◽  
Coupling Reactions ◽  
The Poor ◽  
Human Compact Bone

To enhance the mechanical strength and bioactivity of poly(lactic acid) (PLA) to the level that can be used as a material for spinal implants, poly(glycolic acid) (PGA) fibers and hydroxyapatite (HA) were introduced as fillers to PLA composites. To improve the poor interface between HA and PLA, HA was grafted by PLA to form HA-g-PLA through coupling reactions, and mixed with PLA. The size of the HA particles in the PLA matrix was observed to be reduced from several micrometers to sub-micrometer by grafting PLA onto HA. The tensile and flexural strength of PLA/HA-g-PLA composites were increased compared with those of PLA/HA, apparently due to the better dispersion of HA and stronger interfacial adhesion between the HA and PLA matrix. We also examined the effects of the length and frequency of grafted PLA chains on the tensile strength of the composites. By the addition of unidirectionally aligned PGA fibers, the flexural strength of the composites was greatly improved to a level comparable with human compact bone. In the bioactivity tests, the growth of apatite on the surface was fastest and most uniform in the PLA/PGA fiber/HA-g-PLA composite.

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