Diastereoselective synthesis ofcis-1,3-disubstituted isoindolinesviaa highly site-selective tandem cyclization reaction

2018 ◽  
Vol 5 (12) ◽  
pp. 1950-1956 ◽  
Author(s):  
Siyang Xing ◽  
Hong Cui ◽  
Jiajing Qin ◽  
Nan Gu ◽  
Bowei Zhang ◽  
...  
Keyword(s):  
Michael Addition ◽  
Ring Opening ◽  
Cyclization Reaction ◽  
Tandem Reaction ◽  
Diastereoselective Synthesis ◽  
Tandem Cyclization ◽  
Site Selective

A highly site-selective tandem reaction involving regioselective ring opening of aziridines and Michael addition of electron-deficient alkenes has been described.

A Brønsted acid catalyzed tandem reaction for the diastereoselective synthesis of cyclobuta-fused tetrahydroquinoline carboxylic esters

2021 ◽  
Author(s):  
Valentina Marras ◽  
Pierluigi Caboni ◽  
Francesco Secci ◽  
Régis Guillot ◽  
David J. Aitken ◽  
...  
Keyword(s):  
Michael Addition ◽  
Tandem Reaction ◽  
Bronsted Acid ◽  
Brønsted Acid ◽  
Diastereoselective Synthesis ◽  
Cyclization Process ◽  
Brönsted Acid ◽  
Acid Catalyzed ◽  
Carboxylic Esters

We have established a Brønsted acid catalyzed diastereoselective synthesis of diversely substituted cyclobuta-fused tetrahydroquinoline carboxylic esters through a new tandem aza-Michael addition-aza-Friedel–Crafts cyclization process.

One-Pot Synthesis of Highly Substituted Allenylidene Derivatives via Palladium- or Nickel-Catalyzed Tandem Michael Addition-Cyclization Reaction

2009 ◽  
Vol 351 (1-2) ◽  
pp. 141-146 ◽  
Author(s):  
Yun Shi ◽  
Jing Huang ◽  
Yan-Fang Yang ◽  
Lu-Yong Wu ◽  
Yan-Ning Niu ◽  
...  
Keyword(s):  
Michael Addition ◽  
Cyclization Reaction ◽  
One Pot ◽  
One Pot Synthesis

Uncatalyzed diastereoselective synthesis of alkyliminofurochromone-derived benzylmalononitriles via a three-component cascade reaction: competition between Diels–Alder cycloaddition and Michael addition

2021 ◽  
Author(s):  
Mohammad Bagher Teimouri ◽  
Zahra Mokhtare ◽  
Hamid Reza Khavasi
Keyword(s):  
Michael Addition ◽  
Heterocyclic Ring ◽  
Cascade Reaction ◽  
Diels Alder ◽  
Chemical Bonds ◽  
Diastereoselective Synthesis ◽  
Atom Economy ◽  
One Pot

Three new chemical bonds and three stereogenic centres and one heterocyclic ring were assembled stereoselectively in a convenient high atom-economy one-pot operation.

Stereoselective synthesis of O-tosyl azabicyclic derivatives via aza Prins reaction of endocyclic N-acyliminium ions: application to the total synthesis of (±)-epi-indolizidine 167B and 209D

2014 ◽  
Vol 12 (36) ◽  
pp. 7026-7035 ◽  
Author(s):  
Anil K. Saikia ◽  
Kiran Indukuri ◽  
Jagadish Das
Keyword(s):  
Total Synthesis ◽  
Stereoselective Synthesis ◽  
Cyclization Reaction ◽  
Diastereoselective Synthesis ◽  
Prins Reaction ◽  
Prins Cyclization ◽  
Acyliminium Ions

A diastereoselective synthesis of 4-O-tosyl piperidine containing azabicyclic derivatives has been established via Prins cyclization reaction. This protocol has been applied for the total synthesis of (±)-epi-indolizidine 167B and 209D.

Diastereoselective synthesis of bicyclo[2.2.2]octanes by double Michael addition

1989 ◽  
Vol 30 (5) ◽  
pp. 547-550 ◽  
Author(s):  
Dietrich Spitzner ◽  
Peter Wagner ◽  
Arndt Simon ◽  
Karl Peters
Keyword(s):  
Michael Addition ◽  
Diastereoselective Synthesis

Diastereoselective Synthesis of Vicinal Diamines by Aza-Michael Addition of Chiral Phenethylamine to Nitroalkenes

2018 ◽  
Vol 3 (34) ◽  
pp. 9916-9919
Author(s):  
Chunying Ma ◽  
Jianxun Du ◽  
Yuhua Liang ◽  
Wenhua Feng
Keyword(s):  
Michael Addition ◽  
Diastereoselective Synthesis ◽  
Vicinal Diamines
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