scholarly journals Hypersonic poration of supported lipid bilayers

2019 ◽  
Vol 3 (5) ◽  
pp. 782-790 ◽  
Author(s):  
Yao Lu ◽  
Jurriaan Huskens ◽  
Wei Pang ◽  
Xuexin Duan
Keyword(s):  
Gene Delivery ◽  
Lipid Bilayers ◽  
Biomedical Applications ◽  
Membrane Disruption ◽  
Supported Lipid Bilayers ◽  
New Type ◽  
Disruption Method ◽  
Drug And Gene Delivery

Hypersound (ultrasound of gigahertz (GHz) frequency) has been recently introduced as a new type of membrane-disruption method for cells, vesicles and supported lipid bilayers (SLBs), with the potential to improve the efficiency of drug and gene delivery for biomedical applications.

Graphene and Graphene-Based Materials in Biomedical Applications

2019 ◽  
Vol 26 (38) ◽  
pp. 6834-6850 ◽  
Author(s):  
Mohammad Omaish Ansari ◽  
Kalamegam Gauthaman ◽  
Abdurahman Essa ◽  
Sidi A. Bencherif ◽  
Adnan Memic
Keyword(s):  
Tissue Engineering ◽  
Thermal Properties ◽  
Gene Delivery ◽  
Regenerative Medicine ◽  
Biomedical Research ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
Two Dimensional ◽  
Drug And Gene Delivery ◽  
Biomedical Fields

: Nanobiotechnology has huge potential in the field of regenerative medicine. One of the main drivers has been the development of novel nanomaterials. One developing class of materials is graphene and its derivatives recognized for their novel properties present on the nanoscale. In particular, graphene and graphene-based nanomaterials have been shown to have excellent electrical, mechanical, optical and thermal properties. Due to these unique properties coupled with the ability to tune their biocompatibility, these nanomaterials have been propelled for various applications. Most recently, these two-dimensional nanomaterials have been widely recognized for their utility in biomedical research. In this review, a brief overview of the strategies to synthesize graphene and its derivatives are discussed. Next, the biocompatibility profile of these nanomaterials as a precursor to their biomedical application is reviewed. Finally, recent applications of graphene-based nanomaterials in various biomedical fields including tissue engineering, drug and gene delivery, biosensing and bioimaging as well as other biorelated studies are highlighted.

scholarly journals Silica nanoparticle supported lipid bilayers for gene delivery

2009 ◽  
pp. 5100 ◽  
Author(s):  
Juewen Liu ◽  
Alison Stace-Naughton ◽  
C. Jeffrey Brinker
Keyword(s):  
Gene Delivery ◽  
Lipid Bilayers ◽  
Silica Nanoparticle ◽  
Supported Lipid Bilayers

Interaction of reducible polypeptide gene delivery vectors with supported lipid bilayers: pore formation and structure–function relationships

Soft Matter ◽  
2010 ◽  
Vol 6 (11) ◽  
pp. 2517 ◽  
Author(s):  
Mahmoud Soliman ◽  
Rujikan Nasanit ◽  
Stephanie Allen ◽  
Martyn C. Davies ◽  
Simon S. Briggs ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Structure Function ◽  
Lipid Bilayers ◽  
Pore Formation ◽  
Supported Lipid Bilayers ◽  
Gene Delivery Vectors

Biomedical applications of carbon nanomaterials: Drug and gene delivery potentials

2018 ◽  
Vol 234 (1) ◽  
pp. 298-319 ◽  
Author(s):  
Mohammad Mohajeri ◽  
Behzad Behnam ◽  
Amirhossein Sahebkar
Keyword(s):  
Gene Delivery ◽  
Biomedical Applications ◽  
Carbon Nanomaterials ◽  
Drug And Gene Delivery

Biomedical applications of polymers 2001 - 2002

e-Polymers ◽  
2003 ◽  
Vol 3 (1) ◽  
Author(s):  
Joseph Jagur-Grodzinski
Keyword(s):  
Tissue Engineering ◽  
Gene Therapy ◽  
Gene Delivery ◽  
Drug Release ◽  
Wound Dressing ◽  
Biomedical Applications ◽  
Bone Repair ◽  
Controlled Drug Release ◽  
Artificial Organs ◽  
Drug And Gene Delivery

Abstract Papers published during 2001 - 2002 on the synthesis and preparation of polymers and polymer-based devices and their applications are reviewed. Polymers for drug and gene delivery, gene therapy, controlled drug release, conjugation with peptides, proteins, and nucleotides, tissue engineering, bone repair and regeneration, coatings, wound dressing, artificial skin and other artificial organs are discussed.

Interactions between polystyrene nanoparticles and supported lipid bilayers: impact of charge and hydrophobicity modification by specific anions

2019 ◽  
Vol 6 (6) ◽  
pp. 1829-1837 ◽  
Author(s):  
Zehui Xia ◽  
April Woods ◽  
Amanda Quirk ◽  
Ian J. Burgess ◽  
Boris L. T. Lau
Keyword(s):  
Lipid Bilayers ◽  
Membrane Disruption ◽  
Supported Lipid Bilayers ◽  
Polystyrene Nanoparticles ◽  
Induced Membrane ◽  
Step Process

The interaction between nanoparticles and zwitterionic supported lipid bilayers is a multi-step process, with specific ions exerting their influences on electrostatic-driven NP deposition and hydrophobicity-induced membrane disruption.

Influence of Brain Gangliosides on the Formation and Properties of Supported Lipid Bilayers for Binding Kinetics Studies

2018 ◽  
Author(s):  
Luke Jordan ◽  
Nathan Wittenberg
Keyword(s):  
Lipid Bilayers ◽  
Binding Kinetics ◽  
Supported Lipid Bilayers ◽  
Dependent Manner ◽  
Concentration Dependent Manner ◽  
Supported Lipid Bilayer ◽  
Head Groups ◽  
Lipid Diffusion ◽  
Kinetics Of ◽  
Brain Gangliosides

This is a comprehensive study of the effects of the four major brain gangliosides (GM1, GD1b, GD1a, and GT1b) on the adsorption and rupture of phospholipid vesicles on SiO2 surfaces for the formation of supported lipid bilayer (SLB) membranes. Using quartz crystal microbalance with dissipation monitoring (QCM-D) we show that gangliosides GD1a and GT1b significantly slow the SLB formation process, whereas GM1 and GD1b have smaller effects. This is likely due to the net ganglioside charge as well as the positions of acidic sugar groups on ganglioside glycan head groups. Data is included that shows calcium can accelerate the formation of ganglioside-rich SLBs. Using fluorescence recovery after photobleaching (FRAP) we also show that the presence of gangliosides significantly reduces lipid diffusion coefficients in SLBs in a concentration-dependent manner. Finally, using QCM-D and GD1a-rich SLB membranes we measure the binding kinetics of an anti-GD1a antibody that has similarities to a monoclonal antibody that is a hallmark of a variant of Guillain-Barre syndrome.

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