scholarly journals Significantly enhanced antioxidant activity of chitosan through chemical modification with coumarins

2019 ◽  
Vol 10 (12) ◽  
pp. 1480-1488 ◽  
Author(s):  
Qing Li ◽  
Lijie Wei ◽  
Jingjing Zhang ◽  
Guodong Gu ◽  
Zhanyong Guo
Keyword(s):  
Antioxidant Activity ◽  
Chemical Modification ◽  
Chitosan Derivatives ◽  
New Class

A new class of chitosan derivatives possessing coumarins was synthesized to improve the antioxidant activity of chitosan.

scholarly journals Antioxidant Activity and Antifungal Activity of Chitosan Derivatives with Propane Sulfonate Groups

Polymers ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 395 ◽  
Author(s):  
Fang Luan ◽  
Lijie Wei ◽  
Jingjing Zhang ◽  
Yingqi Mi ◽  
Fang Dong ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Antifungal Activity ◽  
Chitosan Derivatives

scholarly journals A New Class of Synthetic Flavonolignan-Like Dimers: Still Few Molecules, but with Attractive Properties

Molecules ◽  
2018 ◽  
Vol 24 (1) ◽  
pp. 108 ◽  
Author(s):  
Valeria Romanucci ◽  
Giovanni Di Fabio ◽  
Armando Zarrelli
Keyword(s):  
Antioxidant Activity ◽  
Medicinal Chemistry ◽  
Biological Response ◽  
Milk Thistle ◽  
Silybum Marianum ◽  
New Class ◽  
Therapeutic Value ◽  
Recent Developments

In recent years, there has been increasing interest in dimeric molecules due to reports of their promising therapeutic value in the treatment of numerous diseases (such as cancer, HIV, Alzheimer’s and, malaria). Many reports in the literature have highlighted the ability of these molecules to interact not only with specific biologic receptors but also to induce a biological response that more than doubles the results of the corresponding monomeric counterpart. In this regard, flavonolignan dimers or simply bi-flavonolignans are an emerging class of dimeric compounds that unlike bi-flavonoids, which are very widespread in nature, consist of synthetic dimers of some flavonolignans isolated from the milk thistle Silybum marianum [L. Gaertn. (Asteraceae)]. This mini-review will discuss recent developments in the synthesis, characterization and antioxidant activity of new families of flavonolignan dimers, in light of emerging medicinal chemistry strategies.

scholarly journals Modification of Hydroxypropyltrimethyl Ammonium Chitosan with Organic Acid: Synthesis, Characterization, and Antioxidant Activity

Polymers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 2460
Author(s):  
Yingqi Mi ◽  
Wenqiang Tan ◽  
Jingjing Zhang ◽  
Zhanyong Guo
Keyword(s):  
Antioxidant Activity ◽  
Organic Acids ◽  
Organic Acid ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Scavenging Activity ◽  
Chitosan Derivatives ◽  
13C Nuclear Magnetic Resonance ◽  
Wide Range

A novel and green method for the preparation of chitosan derivatives bearing organic acids was reported in this paper. In order to improve the antioxidant activity of chitosan, eight different hydroxypropyltrimethyl ammonium chitosan derivatives were successfully designed and synthesized via introducing of organic acids onto chitosan by mild and non-toxic ion exchange. The data of Fourier Transform Infrared (FTIR), 13C Nuclear Magnetic Resonance (NMR), 1H NMR, and elemental analysis for chitosan derivatives indicated the successful conjugation of organic acid salt with hydroxypropyltrimethyl ammonium chloride chitosan (HACC). Meanwhile, the antioxidant activity of the chitosan derivatives was evaluated in vitro. The results indicated that the chitosan derivatives possessed dramatic enhancements in DPPH-radical scavenging activity, superoxide-radical scavenging activity, hydroxyl radical scavenging ability, and reducing power. Furthermore, the cytotoxicity of the synthesized compounds was investigated in vitro on L929 cells and showed low cytotoxicity. Thus, the enhanced antioxidant property of all novel chitosan products might be a great advantage, while applied in a wide range of applications in the form of antioxidant in biomedical, food, and cosmetic industry.

scholarly journals Synthesis and antioxidant activity of water-soluble chitosan derivatives

IUBMB Life ◽  
1998 ◽  
Vol 44 (5) ◽  
pp. 939-948 ◽  
Author(s):  
Seiichi Matsugo ◽  
Minako Mizuie ◽  
Michiko Matsugo ◽  
Rie Ohwa ◽  
Hiromi Kitano ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Water Soluble ◽  
Chitosan Derivatives

Synthesis and Antioxidant Activity of a New Class of Bis and Tris Heterocycles

2012 ◽  
Vol 345 (9) ◽  
pp. 745-752 ◽  
Author(s):  
Venkatapuram Padmavathi ◽  
Bhumireddy Chinnachennaiahgari Venkatesh ◽  
Akkarapalli Muralikrishna ◽  
Adivireddy Padmaja
Keyword(s):  
Antioxidant Activity ◽  
New Class

Antioxidant activity of water-soluble chitosan derivatives

2001 ◽  
Vol 11 (13) ◽  
pp. 1699-1701 ◽  
Author(s):  
Wenming Xie ◽  
Peixin Xu ◽  
Qing Liu
Keyword(s):  
Antioxidant Activity ◽  
Water Soluble ◽  
Chitosan Derivatives

Synthesis and antioxidant activity of a new class of pyrazolyl indoles, thiazolyl pyrazolyl indoles

2017 ◽  
Vol 26 (7) ◽  
pp. 1574-1584 ◽  
Author(s):  
Nagarjuna Ummadi ◽  
Sravya Gundala ◽  
Padmavathi Venkatapuram ◽  
Padmaja Adivireddy
Keyword(s):  
Antioxidant Activity ◽  
New Class

scholarly journals Ceria nanoparticles with rhodamine B as a powerful theranostic agent against intracellular oxidative stress

RSC Advances ◽  
2015 ◽  
Vol 5 (97) ◽  
pp. 79423-79432 ◽  
Author(s):  
Nadezda Apostolova ◽  
Susana Rovira-Llopis ◽  
Herme G. Baldoví ◽  
Sergio Navalon ◽  
Abdullah M. Asiri ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Rhodamine B ◽  
Human Cells ◽  
Ceria Nanoparticles ◽  
New Class ◽  
Theranostic Agent ◽  
Intracellular Oxidative Stress

Ceria nanoparticles with rhodamine B (RhB-CeNPs) are a new class of biocompatible nanomaterial with antioxidant activity and sensor capacity against oxidant species both in solution and in human cells.

scholarly journals Chitosan Derivatives and Their Application in Biomedicine

2020 ◽  
Vol 21 (2) ◽  
pp. 487 ◽  
Author(s):  
Wenqian Wang ◽  
Qiuyu Meng ◽  
Qi Li ◽  
Jinbao Liu ◽  
Mo Zhou ◽  
...  
Keyword(s):  
Chemical Modification ◽  
Functional Groups ◽  
Organic Solvents ◽  
Chemical Reactions ◽  
Delivery System ◽  
Water Solubility ◽  
Delivery Systems ◽  
Ph Sensitivity ◽  
Chitosan Derivatives ◽  
Application Scope

Chitosan is a product of the deacetylation of chitin, which is widely found in nature. Chitosan is insoluble in water and most organic solvents, which seriously limits both its application scope and applicable fields. However, chitosan contains active functional groups that are liable to chemical reactions; thus, chitosan derivatives can be obtained through the chemical modification of chitosan. The modification of chitosan has been an important aspect of chitosan research, showing a better solubility, pH-sensitive targeting, an increased number of delivery systems, etc. This review summarizes the modification of chitosan by acylation, carboxylation, alkylation, and quaternization in order to improve the water solubility, pH sensitivity, and the targeting of chitosan derivatives. The applications of chitosan derivatives in the antibacterial, sustained slowly release, targeting, and delivery system fields are also described. Chitosan derivatives will have a large impact and show potential in biomedicine for the development of drugs in future.

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