scholarly journals Aspect-ratio-dependent interaction of molecular polymer brushes and multicellular tumour spheroids

2018 ◽  
Vol 9 (25) ◽  
pp. 3461-3465 ◽  
Author(s):  
Markus Müllner ◽  
Kylie Yang ◽  
Amandeep Kaur ◽  
Elizabeth J. New
Keyword(s):  
Aspect Ratio ◽  
Surface Chemistry ◽  
Particle Shape ◽  
Polymer Brushes ◽  
Design Parameters ◽  
Tumour Spheroid ◽  
Tumour Spheroids ◽  
Shape Effects ◽  
Nanoparticle Design ◽  
Dependent Interaction

Molecular polymer brushes allow for independent tailoring of nanoparticle design parameters. Brush particles with altered shape and aspect ratio revealed that particle shape effects may be decoupled from surface chemistry to achieve higher tumour spheroid interaction and penetration.

scholarly journals Clogging sensitivity of flow distributors designed for radially elongated hexagonal pillar array columns: a computational modelling

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Farideh Haghighi ◽  
Zahra Talebpour ◽  
Amir Sanati-Nezhad
Keyword(s):  
Pressure Drop ◽  
Aspect Ratio ◽  
Contact Zone ◽  
Separation Efficiency ◽  
Fluid Dynamic ◽  
Computational Modelling ◽  
Channel Width ◽  
Fluid Distribution ◽  
Design Parameters ◽  
Pillar Array

AbstractFlow distributor located at the beginning of the micromachined pillar array column (PAC) has significant roles in uniform distribution of flow through separation channels and thus separation efficiency. Chip manufacturing artifacts, contaminated solvents, and complex matrix of samples may contribute to clogging of the microfabricated channels, affect the distribution of the sample, and alter the performance of both natural and engineered systems. An even fluid distribution must be achieved cross-sectionally through careful design of flow distributors and minimizing the sensitivity to clogging in order to reach satisfactory separation efficiency. Given the difficulty to investigate experimentally a high number of clogging conditions and geometries, this work exploits a computational fluid dynamic model to investigate the effect of various design parameters on the performance of flow distributors in equally spreading the flow along the separation channels in the presence of different degrees of clogging. An array of radially elongated hexagonal pillars was selected for the separation channel (column). The design parameters include channel width, distributor width, aspect ratio of the pillars, and number of contact zone rows. The performance of known flow distributors, including bifurcating (BF), radially interconnected (RI), and recently introduced mixed-mode (MMI) in addition to two new distributors designed in this work (MMII and MMIII) were investigated in terms of mean elution time, volumetric variance, asymmetry factors, and pressure drop between the inlet and the monitor line for each design. The results show that except for pressure drop, the channel width and aspect ratio of the pillars has no significant influence on flow distribution pattern in non-clogged distributors. However, the behavior of flow distributors in response to clogging was found to be dependent on width of the channels. Also increasing the distributor width and number of contact zone rows after the first splitting stage showed no improvement in the ability to alleviate the clogging. MMI distributor with the channel width of 3 µm, aspect ratio of the pillars equal to 20, number of exits of 8, and number of contact zones of 3 exhibited the highest stability and minimum sensitivity to different degrees of clogging.

scholarly journals Atmospheric Ice Particle Shape Estimates from Polarimetric Radar Measurements and In Situ Observations

2017 ◽  
Vol 34 (12) ◽  
pp. 2569-2587 ◽  
Author(s):  
Sergey Y. Matrosov ◽  
Carl G. Schmitt ◽  
Maximilian Maahn ◽  
Gijs de Boer
Keyword(s):  
Aspect Ratio ◽  
Particle Shape ◽  
Characteristic Size ◽  
In Situ Measurements ◽  
Department Of Energy ◽  
Depolarization Ratio ◽  
Suggested Approach ◽  
Aspect Ratios ◽  
Radar Measurements

AbstractA remote sensing approach to retrieve the degree of nonsphericity of ice hydrometeors using scanning polarimetric Ka-band radar measurements from a U.S. Department of Energy Atmospheric Radiation Measurement (ARM) Program cloud radar operated in an alternate transmission–simultaneous reception mode is introduced. Nonsphericity is characterized by aspect ratios representing the ratios of particle minor-to-major dimensions. The approach is based on the use of a circular depolarization ratio (CDR) proxy reconstructed from differential reflectivity ZDR and copolar correlation coefficient ρhυ linear polarization measurements. Essentially combining information contained in ZDR and ρhυ, CDR-based retrievals of aspect ratios are fairly insensitive to hydrometeor orientation if measurements are performed at elevation angles of around 40°–50°. The suggested approach is applied to data collected using the third ARM Mobile Facility (AMF3), deployed to Oliktok Point, Alaska. Aspect ratio retrievals were also performed using ZDR measurements that are more strongly (compared to CDR) influenced by hydrometeor orientation. The results of radar-based retrievals are compared with in situ measurements from the tethered balloon system (TBS)-based video ice particle sampler and the ground-based multiangle snowflake camera. The observed ice hydrometeors were predominantly irregular-shaped ice crystals and aggregates, with aspect ratios varying between approximately 0.3 and 0.8. The retrievals assume that particle bulk density influencing (besides the particle shape) observed polarimetric variables can be deduced from the estimates of particle characteristic size. Uncertainties of CDR-based aspect ratio retrievals are estimated at about 0.1–0.15. Given these uncertainties, radar-based retrievals generally agreed with in situ measurements. The advantages of using the CDR proxy compared to the linear depolarization ratio are discussed.

Investigation of sustainability of lubricated journal bearing under relevant design parameters

2018 ◽  
Vol 70 (4) ◽  
pp. 789-804 ◽  
Author(s):  
M.M. Shahin ◽  
Mohammad Asaduzzaman Chowdhury ◽  
Md. Arefin Kowser ◽  
Uttam Kumar Debnath ◽  
M.H. Monir
Keyword(s):  
Aspect Ratio ◽  
Elastic Strain ◽  
Journal Bearing ◽  
Design Parameters ◽  
Content Type ◽  
Computational Fluid Dynamics Cfd ◽  
Stress Formation ◽  
Bearing Design ◽  
The Stability ◽  
Bearing Friction

Purpose The purposes of the present study are to ensure higher sustainability of journal bearings under different applied loads and to observe bearing performances such as elastic strain, total deformation and stress formation. Design/methodology/approach A journal bearing test rig was used to determine the effect of the applied load on the bearing friction, film thickness, lubricant film pressure, etc. A steady-state analysis was performed to obtain the bearing performance. Findings An efficient aspect ratio (L/D) range was obtained to increase the durability or the stability of the bearing while the bearing is in the working condition by using SAE 5W-30 oil. The results from the study were compared with previous studies in which different types of oil and water, such as Newtonian fluid (NF), magnetorheological fluid (MRF) and nonmagnetorheological fluid (NMRF), were used as the lubricant. To ensure a preferable aspect ratio range (0.25-0.50), a computational fluid dynamics (CFD) analysis was conducted by ANSYS; the results show a lower elastic strain and deformation within the preferable aspect ratio (0.25-0.50) rather than a higher aspect ratio using the SAE 5W-30 oil. Originality/value It is expected that the findings of this study will contribute to the improvement of the bearing design and the bearing lubricating system.

scholarly journals Aeroelastic Behavior of Low Aspect Ratio Metal and Composite Blades

1986 ◽  
Author(s):  
James F. White ◽  
Oddvar O. Bendiksen
Keyword(s):  
Aspect Ratio ◽  
Opposite Effect ◽  
Design Parameters ◽  
Aeroelastic Stability ◽  
Low Aspect Ratio ◽  
Supersonic Flutter ◽  
Type Mode ◽  
The Stability ◽  
Composite Blades ◽  
Plate Type

The aeroelastic stability of titanium and composite blades of low aspect ratio is examined over a range of design parameters, using a Rayleigh-Ritz formulation. The blade modes include a plate-type mode to account for chordwise bending. Chordwise flexibility is found to have a significant effect on the unstalled supersonic flutter of low aspect ratio blades, and also on the stability of tip sections of shrouded fan blades. For blades with a thickness of less than approximately four percent of chord, the chordwise, second bending, and first torsion branches are all unstable at moderately high supersonic Mach numbers. For composite blades, the important structural coupling between bending and torsion cannot be modeled properly unless chordwise bending is accounted for. Typically, aft fiber sweep produces beneficial bending-torsion coupling that is stabilizing, whereas forward fiber sweep has the opposite effect. By using crossed-ply laminate configurations, critical aeroelastic modes can be stabilized.

scholarly journals Quantitative analysis of tumour spheroid structure

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Alexander P Browning ◽  
Jesse A Sharp ◽  
Ryan J Murphy ◽  
Gency Gunasingh ◽  
Brodie Lawson ◽  
...  
Keyword(s):  
Cell Lines ◽  
Tumour Microenvironment ◽  
Culture Conditions ◽  
Experimental Models ◽  
Seeding Density ◽  
Modelling Framework ◽  
Tumour Spheroid ◽  
Tumour Spheroids ◽  
Wide Range

Tumour spheroids are common in vitro experimental models of avascular tumour growth. Compared with traditional two-dimensional culture, tumour spheroids more closely mimic the avascular tumour microenvironment where spatial differences in nutrient availability strongly influence growth. We show that spheroids initiated using significantly different numbers of cells grow to similar limiting sizes, suggesting that avascular tumours have a limiting structure; in agreement with untested predictions of classical mathematical models of tumour spheroids. We develop a novel mathematical and statistical framework to study the structure of tumour spheroids seeded from cells transduced with fluorescent cell cycle indicators, enabling us to discriminate between arrested and cycling cells and identify an arrested region. Our analysis shows that transient spheroid structure is independent of initial spheroid size, and the limiting structure can be independent of seeding density. Standard experimental protocols compare spheroid size as a function of time; however, our analysis suggests that comparing spheroid structure as a function of overall size produces results that are relatively insensitive to variability in spheroid size. Our experimental observations are made using two melanoma cell lines, but our modelling framework applies across a wide range of spheroid culture conditions and cell lines.

Increasing aspect ratio of particles suppresses buckling in shells formed by drying suspensions

Soft Matter ◽  
2020 ◽  
Vol 16 (42) ◽  
pp. 9643-9647
Author(s):  
Ahmed Al Harraq ◽  
Bhuvnesh Bharti
Keyword(s):  
Aspect Ratio ◽  
Particle Shape ◽  
Colloidal Suspensions ◽  
Shape Anisotropy

The article identifies the role of particle shape anisotropy in suppressing the buckling of drying droplets of colloidal suspensions.

The development of the winged keel for twelve-metre yachts

1986 ◽  
Vol 173 ◽  
pp. 55-71 ◽  
Author(s):  
P. Van Oossanen ◽  
P. N. Joubert
Keyword(s):  
Wind Tunnel ◽  
Aspect Ratio ◽  
Experimental Analysis ◽  
Design Parameters ◽  
Low Aspect Ratio ◽  
Lifting Surface ◽  
Wind Tunnel Measurements ◽  
America’S Cup

In this paper the authors present a numerical and experimental analysis of the winged keel originally developed for the International twelve-metre class yacht Australia II that won the America's Cup in 1983. After briefly explaining why this keel was evolved in 1981, some basic considerations are presented relating keel performance to various design parameters. The results of numerical flow analyses and wind-tunnel measurements on a model of a winged keel are then presented and compared. The differences between the performance with and without winglets fitted to the keel are discussed. The fitting of winglets appreciably enhances the performance of a low-aspect-ratio lifting surface such as the keel of a twelve-metre yacht.

Fuel particle shape effects in the packed bed combustion of wood

2018 ◽  
Vol 198 ◽  
pp. 100-111 ◽  
Author(s):  
Élizabeth Trudel ◽  
William L.H. Hallett ◽  
Evan Wiens ◽  
Jeremiah D. O'Neil ◽  
Marina K. Busigin ◽  
...  
Keyword(s):  
Particle Shape ◽  
Packed Bed ◽  
Fuel Particle ◽  
Shape Effects
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