scholarly journals Core–shell polymeric nanoparticles comprising BODIPY and fluorescein as ultra-bright ratiometric fluorescent pH sensors

2019 ◽  
Vol 18 (5) ◽  
pp. 1156-1165 ◽  
Author(s):  
Chloé Grazon ◽  
Yang Si ◽  
Jean-Pierre Placial ◽  
Jutta Rieger ◽  
Rachel Méallet-Renault ◽  
...  
Keyword(s):  
Polymeric Nanoparticles ◽  
Ph Sensitive ◽  
Core Shell ◽  
Fluorescent Nanoparticles ◽  
Ph Sensors ◽  
Fluorescence Response

Ultra-bright pH-sensitive fluorescent nanoparticles, including BODIPY in their core and fluorescein in their shell, are synthesized. They contain more than 2500 fluorophores and exhibit a linear fluorescence response between pH 5.5 and 7.5.

Synthesis and characterization of thermosensitive core–shell polymeric nanoparticles

2011 ◽  
Vol 67 (6) ◽  
pp. 985-995 ◽  
Author(s):  
I. A. Facundo ◽  
M. J. Soria ◽  
M. G. Rosales ◽  
L. E. Elizalde ◽  
R. Díaz de León ◽  
...  
Keyword(s):  
Polymeric Nanoparticles ◽  
Synthesis And Characterization ◽  
Core Shell

Molecular beacon-decorated polymethylmethacrylate core-shell fluorescent nanoparticles for the detection of survivin mRNA in human cancer cells

2017 ◽  
Vol 88 ◽  
pp. 15-24 ◽  
Author(s):  
Barbara Adinolfi ◽  
Mario Pellegrino ◽  
Ambra Giannetti ◽  
Sara Tombelli ◽  
Cosimo Trono ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Molecular Beacon ◽  
Human Cancer ◽  
Core Shell ◽  
Fluorescent Nanoparticles ◽  
Survivin Mrna ◽  
Human Cancer Cells

scholarly journals ATRP-based synthesis of a pH-sensitive amphiphilic block polymer and its self-assembled micelles with hollow mesoporous silica as DOX carriers for controlled drug release

RSC Advances ◽  
2021 ◽  
Vol 11 (48) ◽  
pp. 29986-29996
Author(s):  
Xiuxiu Qi ◽  
Hongmei Yan ◽  
Yingxue Li
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Self Assembly ◽  
Drug Loading ◽  
Controlled Drug Release ◽  
Ph Sensitive ◽  
Core Shell ◽  
Assembly Process ◽  
Block Polymer ◽  
Hollow Mesoporous Silica

A pH-sensitive core–shell nanoparticle (HMS@C18@PSDMA-b-POEGMA) was developed via a self-assembly process as the carrier of anticancer drug doxorubicin (DOX) for drug loading and controlled release.

scholarly journals pH Sensitive Peptide Functionalized High Stability Polymeric Nanoparticles for Mitochondria Targeted Cancer Drug Delivery

2019 ◽  
Vol 116 (3) ◽  
pp. 465a ◽  
Author(s):  
Palanikumar Loganathan ◽  
Mona Kalmouni ◽  
Sumaya Al Hosani ◽  
Mazin M. Magzoub
Keyword(s):  
Drug Delivery ◽  
High Stability ◽  
Polymeric Nanoparticles ◽  
Ph Sensitive ◽  
Cancer Drug ◽  
Cancer Drug Delivery

scholarly journals Synthesis of bi-phase dispersible core-shell FeAu@ZnO magneto-opto-fluorescent nanoparticles

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Xue-Mei Li ◽  
Hong-Ling Liu ◽  
Xiao Liu ◽  
Ning Fang ◽  
Xian-Hong Wang ◽  
...  
Keyword(s):  
Core Shell ◽  
Fluorescent Nanoparticles

A Facile Synthesis of Acid-Activatable Nanoparticles for Efficient Intracellular Doxorubicin Release

2017 ◽  
Vol 46 ◽  
pp. 20-30 ◽  
Author(s):  
Cao Ming ◽  
Xiao Wan Song ◽  
Yu Jiao Zhang ◽  
Chang Zhi Xu ◽  
Peng Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hela Cells ◽  
Laser Scanning ◽  
Human Cancer ◽  
Polymeric Nanoparticles ◽  
Confocal Laser Scanning Microscope ◽  
Ph Sensitive ◽  
Confocal Laser ◽  
Cell Nuclei

pH responsive polymeric nanoparticles have emerged as a promising technology platform for targeted and controlled drug delivery in recent years. In this paper, endosomal pH-activatable doxorubicin (DOX) and core-crosslinked polymeric nanoparticles (DCNPs) were prepared and investigated for potent growth inhibition of human cancer cells in vitro. In vitro drug release studies, DOX conjugated nanoparticles with hydrazone bond showed a pH sensitive release phenomenon, that is, the releasing is significantly faster at mildly acidic condition with pH of 5.5 than that at physiological condition. Confocal laser scanning microscope (CLSM) observations revealed that DOX conjugated nanoparticles delivered and released DOX into the cytosols as well as cell nuclei of Hela cells following 6 h incubation. MTT assays demonstrated that these pH-sensitive DOX nanoparticles exhibited high antitumor effect to HeLa cells. The conjugated DOX polymeric nanoparticles may be a promising candidate as a nanoscale and pH-sensitive drug delivery vehicle for cancer therapy.

scholarly journals Holistic Assessment of Covalently Labeled Core–Shell Polymeric Nanoparticles with Fluorescent Contrast Agents for Theranostic Applications

Langmuir ◽  
2014 ◽  
Vol 30 (2) ◽  
pp. 631-641 ◽  
Author(s):  
Tiffany P. Gustafson ◽  
Young H. Lim ◽  
Jeniree A. Flores ◽  
Gyu Seong Heo ◽  
Fuwu Zhang ◽  
...  
Keyword(s):  
Contrast Agents ◽  
Polymeric Nanoparticles ◽  
Core Shell ◽  
Holistic Assessment ◽  
Theranostic Applications
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