scholarly journals Investigation of the factors affecting the photothermal therapy potential of small iron oxide nanoparticles over the 730–840 nm spectral region

2018 ◽  
Vol 17 (11) ◽  
pp. 1787-1793 ◽  
Author(s):  
K. Bilici ◽  
A. Muti ◽  
F. Demir Duman ◽  
A. Sennaroğlu ◽  
H. Yağcı Acar
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Spectral Region ◽  
Photothermal Therapy ◽  
Laser Intensity ◽  
Excitation Wavelength ◽  
Oxide Nanoparticles ◽  
Factors Affecting

Photothermal activity of SPIONs is not dependent on the excitation wavelength, attenuation or laser intensity but to the power.

scholarly journals Depleting tumor-associated Tregs via nanoparticle-mediated hyperthermia to enhance anti-CTLA-4 immunotherapy

Nanomedicine ◽  
2020 ◽  
Vol 15 (1) ◽  
pp. 77-92 ◽  
Author(s):  
Hongwei Chen ◽  
Xin Luan ◽  
Hayley J Paholak ◽  
Joseph P Burnett ◽  
Nicholas O Stevers ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Iron Oxide ◽  
Combination Therapy ◽  
Tumor Growth ◽  
Iron Oxide Nanoparticles ◽  
Photothermal Therapy ◽  
Breast Tumors ◽  
Significant Inhibition ◽  
Oxide Nanoparticles ◽  
Novel Strategy

Aim: We aim to demonstrate that a local nanoparticle-mediated hyperthermia can effectively eliminate tumor-associated Tregs and thereby boost checkpoint blockade-based immunotherapy. Materials & methods: Photothermal therapy (PTT), mediated with systemically administered stealthy iron-oxide nanoparticles, was applied to treat BALB/c mice bearing 4T1 murine breast tumors. Flow cytometry was applied to evaluate both Treg and CD8+ T-cell population. Tumor growth following combination therapy of both PTT and anti-CTLA-4 was further evaluated. Results: Our data reveal that tumor-associated Tregs can be preferentially depleted via iron-oxide nanoparticles-mediated PTT. When combining PTT with anti-CTLA-4 immunotherapy, we demonstrate a significant inhibition of syngeneic 4T1 tumor growth. Conclusion: This study offers a novel strategy to overcome Treg-mediated immunosuppression and thereby to boost cancer immunotherapy.

scholarly journals Synthesis and encapsulation of iron oxide nanorods for application in magnetic hyperthermia and photothermal therapy

2021 ◽  
Vol 11 (1) ◽  
pp. 176-190
Author(s):  
Lijo P. Mona ◽  
Sandile P. Songca ◽  
Peter A. Ajibade
Keyword(s):  
Cell Death ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Photothermal Therapy ◽  
Magnetic Hyperthermia ◽  
Synthetic Methods ◽  
Oxide Nanoparticles ◽  
Magnetic Oxide ◽  
Magnetic Iron Oxide ◽  
Oxide Nanorods

Abstract The synthesis, characterization, and applications of iron oxide nanorods have received attention in recent years. Even though there are several studies on the biological applications of iron oxide nanoparticles, recent studies have shown that rod-shaped iron oxides are effective in magnetic hyperthermia (MHT) as therapeutic technique to treat cancer. This review focused on the synthesis and encapsulation of magnetic iron oxide nanorods (MIONRs) and their use in (MHT) and photothermal therapy (PTT) for cancer cells. Among the synthetic methods that have been used to prepare MIONRs, some could be used to precisely control the particle size of the as-prepared magnetic iron oxide nanoparticles (MIONs), while others could be used to prepare monodisperse particles with uniform size distributions. Some of the results presented in this review showed that magnetic oxide nanorods are more potent in MHT than polyhedral-shaped MIONs. The review shows that mixtures of polyhedral- and rod-shaped MIONs resulted in 59 and 77% cell death, while monodisperse MIONRs resulted in 95% cell death. It could thus be concluded that, for magnetic iron oxide to be effective in MHT and PTT, it is important to prepare monodisperse magnetic oxide nanorods.

scholarly journals Iron Oxide Nanoparticles in Photothermal Therapy

Molecules ◽  
2018 ◽  
Vol 23 (7) ◽  
pp. 1567 ◽  
Author(s):  
Joan Estelrich ◽  
Maria Busquets
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Photothermal Therapy ◽  
Oxide Nanoparticles

scholarly journals J‐Aggregates of Organic Dye Molecules Complexed with Iron Oxide Nanoparticles for Imaging‐Guided Photothermal Therapy Under 915‐nm Light

Small ◽  
2021 ◽  
Vol 17 (2) ◽  
pp. 2007013
Author(s):  
Xuejiao Song ◽  
Hua Gong ◽  
Teng Liu ◽  
Liang Cheng ◽  
Chao Wang ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Photothermal Therapy ◽  
Organic Dye ◽  
Oxide Nanoparticles ◽  
Dye Molecules ◽  
J Aggregates

scholarly journals Iron Oxide Nanoparticle-Based Hyperthermia as a Treatment Option in Various Gastrointestinal Malignancies

Nanomaterials ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 3013
Author(s):  
Julian Palzer ◽  
Lea Eckstein ◽  
Ioana Slabu ◽  
Oliver Reisen ◽  
Ulf P. Neumann ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Cancer Treatment ◽  
Iron Oxide Nanoparticles ◽  
Magnetic Fluid ◽  
Photothermal Therapy ◽  
Iron Oxide Nanoparticle ◽  
Oxide Nanoparticles ◽  
Gastrointestinal Malignancies ◽  
Magnetic Fluid Hyperthermia ◽  
Oxide Nanoparticle

Iron oxide nanoparticle-based hyperthermia is an emerging field in cancer treatment. The hyperthermia is primarily achieved by two differing methods: magnetic fluid hyperthermia and photothermal therapy. In magnetic fluid hyperthermia, the iron oxide nanoparticles are heated by an alternating magnetic field through Brownian and Néel relaxation. In photothermal therapy, the hyperthermia is mainly generated by absorption of light, thereby converting electromagnetic waves into thermal energy. By use of iron oxide nanoparticles, this effect can be enhanced. Both methods are promising tools in cancer treatment and are, therefore, also explored for gastrointestinal malignancies. Here, we provide an extensive literature research on both therapy options for the most common gastrointestinal malignancies (esophageal, gastric and colorectal cancer, colorectal liver metastases, hepatocellular carcinoma, cholangiocellular carcinoma and pancreatic cancer). As many of these rank in the top ten of cancer-related deaths, novel treatment strategies are urgently needed. This review describes the efforts undertaken in vitro and in vivo.

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