Tolerance of N2-heteroaryl modifications on guanine bases in a DNA G-quadruplex

2019 ◽  
Vol 17 (4) ◽  
pp. 859-866
Author(s):  
Yoshiaki Masaki ◽  
Takeshi Inde ◽  
Atsuya Maruyama ◽  
Kohji Seio
Keyword(s):  
Telomere Sequence ◽  
G Quadruplex ◽  
Human Telomere ◽  
The Stability

To systematically determine the effect of N2-heteroaryl modification on the stability of G-quadruplex structures, six types of N2-heteroarylated deoxyguanosines were incorporated into oligonucleotides with intramolecular quadruplex-forming sequences obtained from the human telomere sequence.

Single-Molecule Analysis of Human Telomere Sequence Interactions with G-quadruplex Ligand

2016 ◽  
Vol 88 (8) ◽  
pp. 4533-4540 ◽  
Author(s):  
Ling Zhang ◽  
Kaixiang Zhang ◽  
Sana Rauf ◽  
Duo Dong ◽  
Yang Liu ◽  
...  
Keyword(s):  
Single Molecule ◽  
Telomere Sequence ◽  
G Quadruplex ◽  
Human Telomere ◽  
Single Molecule Analysis

scholarly journals Single-molecule investigation of G-quadruplex folds of the human telomere sequence in a protein nanocavity

2014 ◽  
Vol 111 (40) ◽  
pp. 14325-14331 ◽  
Author(s):  
Na An ◽  
Aaron M. Fleming ◽  
Eric G. Middleton ◽  
Cynthia J. Burrows
Keyword(s):  
Single Molecule ◽  
Telomere Sequence ◽  
G Quadruplex ◽  
Human Telomere

scholarly journals Pressure Perturbation Studies of Noncanonical Viral Nucleic Acid Structures

Biology ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1173
Author(s):  
Judit Somkuti ◽  
Orsolya Réka Molnár ◽  
Anna Grád ◽  
László Smeller
Keyword(s):  
Cell Proliferation ◽  
Cell Death ◽  
Pressure Perturbation ◽  
Viral Nucleic Acid ◽  
Cationic Porphyrin ◽  
G Quadruplex ◽  
Human Telomere ◽  
Temperature And Pressure ◽  
The Stability ◽  
Nucleic Acid Structures

G-quadruplexes are noncanonical structures formed by guanine-rich sequences of the genome. They are found in crucial loci of the human genome, they take part in the regulation of important processes like cell proliferation and cell death. Much less is known about the subjects of this work, the viral G-quadruplexes. We have chosen three potentially G-quadruplex-forming sequences of hepatitis B. We measured the stability and the thermodynamic parameters of these quadruplexes. We also investigated the potential stabilization of these G-quadruplexes by binding a special ligand that was originally developed for cancer therapy. Fluorescence and infrared spectroscopic measurements were performed over wide temperature and pressure ranges. Our experiments indicate the small unfolding volume change of all three oligos. We found a difference between the unfolding of the 2-quartet and the 3-quartet G-quadruplexes. All three G-quadruplexes were stabilized by TMPyP4, which is a cationic porphyrin developed for stabilizing the human telomere.

An in Silico Investigation of Binding Modes and Pathway of APTO-253 on c-KIT G-Quadruplex DNA

2020 ◽  
Author(s):  
Saikat Pal ◽  
Sandip Paul
Keyword(s):  
Cancer Therapy ◽  
In Silico ◽  
Binding Modes ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
The Stability

The stability of c-KIT G-quadruplex DNA by ligands has been a significant concern in the growing field of cancer therapy. Thus, it is very important to understand the mechanism behind...

scholarly journals Human telomere double G-quadruplex recognition by berberine-bisquinolinium imaging conjugates in vitro and in cells

2020 ◽  
Vol 158 ◽  
pp. 1299-1309
Author(s):  
Ting-Cong Liao ◽  
Tian-Zhu Ma ◽  
Suo-Bin Chen ◽  
Agostino Cilibrizzi ◽  
Meng-Jia Zhang ◽  
...  
Keyword(s):  
G Quadruplex ◽  
Human Telomere ◽  
In Cells
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