Experimental and numerical evaluation of a genetically engineered M13 bacteriophage with high sensitivity and selectivity for 2,4,6-trinitrotoluene

2019 ◽  
Vol 17 (23) ◽  
pp. 5666-5670 ◽  
Author(s):  
Won-Geun Kim ◽  
Chris Zueger ◽  
Chuntae Kim ◽  
Winnie Wong ◽  
Vasanthan Devaraj ◽  
...  
Keyword(s):  
Quantum Mechanics ◽  
Numerical Evaluation ◽  
High Sensitivity ◽  
Genetically Engineered ◽  
Experimental Results ◽  
Sensor System ◽  
M13 Bacteriophage ◽  
Sensitivity And Selectivity

This study includes the experimental results of a sensitive M13 bacteriophage-based sensor system that are well matched with the quantum mechanics calculation.

scholarly journals Hierarchical Cluster Analysis of Medical Chemicals Detected by a Bacteriophage-Based Colorimetric Sensor Array

Nanomaterials ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 121 ◽  
Author(s):  
Chuntae Kim ◽  
Hansong Lee ◽  
Vasanthan Devaraj ◽  
Won-Geun Kim ◽  
Yujin Lee ◽  
...  
Keyword(s):  
Cluster Analysis ◽  
Hierarchical Cluster Analysis ◽  
Sensor Array ◽  
Hierarchical Cluster ◽  
Genetically Engineered ◽  
Sensor System ◽  
M13 Bacteriophage ◽  
Biosensor System ◽  
Target Molecules ◽  
Colorimetric Sensors

M13 bacteriophage-based colorimetric sensors, especially multi-array sensors, have been successfully demonstrated to be a powerful platform for detecting extremely small amounts of target molecules. Colorimetric sensors can be fabricated easily using self-assembly of genetically engineered M13 bacteriophage which incorporates peptide libraries on its surface. However, the ability to discriminate many types of target molecules is still required. In this work, we introduce a statistical method to efficiently analyze a huge amount of numerical results in order to classify various types of target molecules. To enhance the selectivity of M13 bacteriophage-based colorimetric sensors, a multi-array sensor system can be an appropriate platform. On this basis, a pattern-recognizing multi-array biosensor platform was fabricated by integrating three types of sensors in which genetically engineered M13 bacteriophages (wild-, RGD-, and EEEE-type) were utilized as a primary building block. This sensor system was used to analyze a pattern of color change caused by a reaction between the sensor array and external substances, followed by separating the specific target substances by means of hierarchical cluster analysis. The biosensor platform could detect drug contaminants such as hormone drugs (estrogen) and antibiotics. We expect that the proposed biosensor system could be used for the development of a first-analysis kit, which would be inexpensive and easy to supply and could be applied in monitoring the environment and health care.

Schottky diodes based on 2D materials for environmental gas monitoring: a review on emerging trends, recent developments and future perspectives

2021 ◽  
Author(s):  
Minu Mathew ◽  
Chandra Sekhar Rout
Keyword(s):  
Gas Sensing ◽  
2D Materials ◽  
Schottky Diodes ◽  
High Sensitivity ◽  
Future Perspectives ◽  
Working Temperature ◽  
Emerging Trends ◽  
Gas Sensing Properties ◽  
Recent Developments ◽  
Sensitivity And Selectivity

This review details the fundamentals, working principles and recent developments of Schottky junctions based on 2D materials to emphasize their improved gas sensing properties including low working temperature, high sensitivity, and selectivity.

The build of nonlinear quantum mechancs and variations of feature of microscopic particles as well as their experimental affirmation

2014 ◽  
Vol 5 (3) ◽  
pp. 871-981 ◽  
Author(s):  
Pang Xiao Feng
Keyword(s):  
Wave Function ◽  
Quantum Mechanics ◽  
Lagrange Equation ◽  
Minimum Principle ◽  
Superposition Principle ◽  
Type Equation ◽  
Experimental Results ◽  
Traditional Concept ◽  
Nonlinear Quantum ◽  
Nonlinear Quantum Mechanics

We establish the nonlinear quantum mechanics due to difficulties and problems of original quantum mechanics, in which microscopic particles have only a wave feature, not corpuscle feature, which are completely not consistent with experimental results and traditional concept of particle. In this theory the microscopic particles are no longer a wave, but localized and have a wave-corpuscle duality, which are represented by the following facts, the solutions of dynamic equation describing the particles have a wave-corpuscle duality, namely it consists of a mass center with constant size and carrier wave, is localized and stable and has a determinant mass, momentum and energy, which obey also generally conservation laws of motion, their motions meet both the Hamilton equation, Euler-Lagrange equation and Newton-type equation, their collision satisfies also the classical rule of collision of macroscopic particles, the uncertainty of their position and momentum is denoted by the minimum principle of uncertainty. Meanwhile the microscopic particles in this theory can both propagate in solitary wave with certain frequency and amplitude and generate reflection and transmission at the interfaces, thus they have also a wave feature, which but are different from linear and KdV solitary wave’s. Therefore the nonlinear quantum mechanics changes thoroughly the natures of microscopic particles due to the nonlinear interactions. In this investigation we gave systematically and completely the distinctions and variations between linear and nonlinear quantum mechanics, including the significances and representations of wave function and mechanical quantities, superposition principle of wave function, property of microscopic particle, eigenvalue problem, uncertainty relation and the methods solving the dynamic equations, from which we found nonlinear quantum mechanics is fully new and different from linear quantum mechanics. Finally, we verify further the correctness of properties of microscopic particles described by nonlinear quantum mechanics using the experimental results of light soliton in fiber and water soliton, which are described by same nonlinear Schrödinger equation. Thus we affirm that nonlinear quantum mechanics is correct and useful, it can be used to study the real properties of microscopic particles in physical systems.

Lanthanide coordination polymer-based biosensor for citrate detection in urine

2019 ◽  
Vol 11 (10) ◽  
pp. 1405-1409 ◽  
Author(s):  
Haoshuang Shen ◽  
Baoxia Liu ◽  
Daosheng Liu ◽  
Xu Zhu ◽  
Xiuhua Wei ◽  
...  
Keyword(s):  
Coordination Polymer ◽  
High Sensitivity ◽  
Lanthanide Coordination Polymer ◽  
Sensitivity And Selectivity

GMP ligand based LCP sensor for Cit with high sensitivity and selectivity was constructed.

Luminescent nucleotide/Tb3+ coordination polymer for Fe(ii) detection in human serum

2020 ◽  
Vol 12 (8) ◽  
pp. 1122-1130
Author(s):  
Yan Liu ◽  
Lu-Lu Peng ◽  
Wei-Xiong Huang ◽  
Hui-Zhuo Zhou ◽  
Li Xu
Keyword(s):  
Coordination Polymer ◽  
Human Serum ◽  
Adenosine Triphosphate ◽  
High Sensitivity ◽  
Sensitivity And Selectivity ◽  
Bridge Ligand

A luminescent nucleotide/Tb3+ coordination polymer (CP) was synthesized using adenosine triphosphate (ATP) molecules as a bridge ligand and Phen as a sensitizer, which showed high sensitivity and selectivity for Fe2+.

Efficient chemosensors for toxic pollutants based on photoluminescent Zn(II) and Cd(II) metal-organic networks

2021 ◽  
Author(s):  
Luis David Rosales-Vazquez ◽  
Alejandro Dorazco-González ◽  
Victor Sanchez-Mendieta
Keyword(s):  
Optical Sensors ◽  
Three Dimensional ◽  
High Sensitivity ◽  
Environmental Research ◽  
Toxic Pollutants ◽  
Sensitivity And Selectivity ◽  
Metal Organic ◽  
Analytical Tools ◽  
Organic Networks

Optical sensors with high sensitivity and selectivity, as important analytical tools for chemical and environmental research, can be accomplished by straightforward synthesis of luminescent one-, two- and three-dimensional Zn(II) and...

scholarly journals Metal Oxide Nanorods-Based Sensor Array for Selective Detection of Biomarker Gases

Sensors ◽  
2021 ◽  
Vol 21 (5) ◽  
pp. 1922
Author(s):  
Gwang Su Kim ◽  
Yumin Park ◽  
Joonchul Shin ◽  
Young Geun Song ◽  
Chong-Yun Kang
Keyword(s):  
Real Time ◽  
Sensor Array ◽  
High Sensitivity ◽  
Gas Analysis ◽  
Diagnostic Methods ◽  
Real Time Monitoring ◽  
Non Invasive ◽  
Sensitivity And Selectivity ◽  
Breath Gas Analysis ◽  
Angle Method

The breath gas analysis through gas phase chemical analysis draws attention in terms of non-invasive and real time monitoring. The array-type sensors are one of the diagnostic methods with high sensitivity and selectivity towards the target gases. Herein, we presented a 2 × 4 sensor array with a micro-heater and ceramic chip. The device is designed in a small size for portability, including the internal eight-channel sensor array. In2O3 NRs and WO3 NRs manufactured through the E-beam evaporator’s glancing angle method were used as sensing materials. Pt, Pd, and Au metal catalysts were decorated for each channel to enhance functionality. The sensor array was measured for the exhaled gas biomarkers CH3COCH3, NO2, and H2S to confirm the respiratory diagnostic performance. Through this operation, the theoretical detection limit was calculated as 1.48 ppb for CH3COCH3, 1.9 ppt for NO2, and 2.47 ppb for H2S. This excellent detection performance indicates that our sensor array detected the CH3COCH3, NO2, and H2S as biomarkers, applying to the breath gas analysis. Our results showed the high potential of the gas sensor array as a non-invasive diagnostic tool that enables real-time monitoring.

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