Biosynthesis of the uridine-derived nucleoside antibiotic A-94964: identification and characterization of the biosynthetic gene cluster provide insight into the biosynthetic pathway

2019 ◽  
Vol 17 (3) ◽  
pp. 461-466 ◽  
Author(s):  
Taro Shiraishi ◽  
Makoto Nishiyama ◽  
Tomohisa Kuzuyama
Keyword(s):  
Gene Cluster ◽  
In Silico ◽  
Biosynthetic Pathway ◽  
Gene Deletion ◽  
Biosynthetic Gene Cluster ◽  
Biosynthetic Gene ◽  
Identification And Characterization ◽  
Insight Into

The biosynthetic pathway of the uridine-derived nucleoside antibiotic A-94964 was proposed via in silico analysis coupled with gene deletion experiments.

Identification and Characterization of the Althiomycin Biosynthetic Gene Cluster in Myxococcus xanthus DK897

ChemBioChem ◽  
2011 ◽  
Vol 12 (9) ◽  
pp. 1411-1416 ◽  
Author(s):  
Niña Socorro Cortina ◽  
Ole Revermann ◽  
Daniel Krug ◽  
Rolf Müller
Keyword(s):  
Gene Cluster ◽  
Myxococcus Xanthus ◽  
Biosynthetic Gene Cluster ◽  
Biosynthetic Gene ◽  
Identification And Characterization

scholarly journals Cloning and Characterization of the Biosynthetic Gene Cluster for Tomaymycin, an SJG-136 Monomeric Analog

2009 ◽  
Vol 75 (9) ◽  
pp. 2958-2963 ◽  
Author(s):  
Wei Li ◽  
ShenChieh Chou ◽  
Ankush Khullar ◽  
Barbara Gerratana
Keyword(s):  
Cluster Analysis ◽  
Gene Cluster ◽  
Biosynthetic Pathway ◽  
Biosynthetic Gene Cluster ◽  
Gene Replacement ◽  
Biosynthetic Gene

ABSTRACT Tomaymycin produced by Streptomyces achromogenes is a naturally produced pyrrolobenzodiazepine (PBD). The biosynthetic gene cluster for tomaymycin was identified and sequenced. The gene cluster analysis reveals a novel biosynthetic pathway for the anthranilate moiety of PBDs. Gene replacement and chemical complementation studies were used to confirm the proposed biosynthetic pathway.

Identification and characterization of the verticillin biosynthetic gene cluster in Clonostachys rogersoniana

2017 ◽  
Vol 103 ◽  
pp. 25-33 ◽  
Author(s):  
Ying Wang ◽  
Pengjie Hu ◽  
Yuanyuan Pan ◽  
Yaxin Zhu ◽  
Xingzhong Liu ◽  
...  
Keyword(s):  
Gene Cluster ◽  
Biosynthetic Gene Cluster ◽  
Biosynthetic Gene ◽  
Identification And Characterization

scholarly journals Identification and characterization of the biosynthetic gene cluster of polyoxypeptin A, a potent apoptosis inducer

2014 ◽  
Vol 14 (1) ◽  
pp. 30 ◽  
Author(s):  
Yanhua Du ◽  
Yemin Wang ◽  
Tingting Huang ◽  
Meifeng Tao ◽  
Zixin Deng ◽  
...  
Keyword(s):  
Gene Cluster ◽  
Biosynthetic Gene Cluster ◽  
Biosynthetic Gene ◽  
Apoptosis Inducer ◽  
Identification And Characterization

scholarly journals Identification and Characterization of a Welwitindolinone Alkaloid Biosynthetic Gene Cluster in the Stigonematalean CyanobacteriumHapalosiphon welwitschii

ChemBioChem ◽  
2014 ◽  
Vol 15 (5) ◽  
pp. 665-669 ◽  
Author(s):  
Matthew L. Hillwig ◽  
Heather A. Fuhrman ◽  
Kuljira Ittiamornkul ◽  
Tyler J. Sevco ◽  
Daniel H. Kwak ◽  
...  
Keyword(s):  
Gene Cluster ◽  
Biosynthetic Gene Cluster ◽  
Biosynthetic Gene ◽  
Identification And Characterization
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