Hydroaminoalkylation of sterically hindered alkenes with N,N-dimethyl anilines using a scandium catalyst

2019 ◽  
Vol 17 (7) ◽  
pp. 2013-2019 ◽  
Author(s):  
Jianhong Su ◽  
Yiqun Zhou ◽  
Xin Xu
Keyword(s):  
Bond Formation ◽  
Sterically Demanding ◽  
Sterically Hindered

Atom-economical and regioselective C(sp3)–C(sp3) bond formation has been achieved by C(sp3)–H alkylation of N,N-dimethyl anilines with sterically demanding alkenes by scandium catalysis.

scholarly journals The effects of introducing sterically demanding aryl substituents in [Cu(N^N)(P^P)]+ complexes

2017 ◽  
Vol 46 (19) ◽  
pp. 6379-6391 ◽  
Author(s):  
Fabian Brunner ◽  
Stefan Graber ◽  
Yann Baumgartner ◽  
Daniel Häussinger ◽  
Alessandro Prescimone ◽  
...  
Keyword(s):  
Aryl Substituent ◽  
Sterically Demanding ◽  
Sterically Hindered

[Cu(6-Arbpy)(POP)][PF6] and [Cu(6-Arbpy)(xantphos)][PF6] compounds in which Ar is a sterically hindered aryl substituent are described; structural and solution dynamical consequences of the bulky groups are investigated.

A simple and greener approach for the amide bond formation employing FeCl3 as a catalyst

2015 ◽  
Vol 39 (10) ◽  
pp. 7746-7749 ◽  
Author(s):  
Basavaprabhu Basavaprabhu ◽  
Krishnamurthy Muniyappa ◽  
Nageswara Rao Panguluri ◽  
Panduranga Veladi ◽  
Vommina V. Sureshbabu
Keyword(s):  
Amino Acids ◽  
Bond Formation ◽  
Amide Bond ◽  
Bromoacetic Acid ◽  
Amide Bond Formation ◽  
Glacial Acoh ◽  
Sterically Hindered

A protocol employing FeCl3 in the presence of glacial AcOH is described for the less nucleophilic aniline and its variants, bromoacetic acid and sterically hindered amino acids.

scholarly journals Organocopper cross-coupling reaction for C–C bond formation on highly sterically hindered structures

2019 ◽  
Vol 10 (24) ◽  
pp. 6107-6112 ◽  
Author(s):  
Miku Oi ◽  
Ryo Takita ◽  
Junichiro Kanazawa ◽  
Atsuya Muranaka ◽  
Chao Wang ◽  
...  
Keyword(s):  
Bond Formation ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Carbon Bond ◽  
Carbon Carbon Bond ◽  
Cross Coupling Reaction ◽  
Sterically Hindered

A potent cross-coupling methodology that enables efficient carbon–carbon bond formation at sterically hindered sp2- and sp3-carbons has been developed.

scholarly journals A protocol for amide bond formation with electron deficient amines and sterically hindered substrates

2016 ◽  
Vol 14 (2) ◽  
pp. 430-433 ◽  
Author(s):  
Maria E. Due-Hansen ◽  
Sunil K. Pandey ◽  
Elisabeth Christiansen ◽  
Rikke Andersen ◽  
Steffen V. F. Hansen ◽  
...  
Keyword(s):  
Elevated Temperature ◽  
Bond Formation ◽  
Amide Bond ◽  
Standard Methods ◽  
Amide Bond Formation ◽  
Amide Coupling ◽  
Sterically Hindered

A protocol for amide coupling by in situ formation of acyl fluorides and reaction with amines at elevated temperature has been developed and found to be efficient for coupling of sterically hindered substrates and electron deficient amines where standard methods failed.

Sterically demanding zinc(ii) phthalocyanines: synthesis, optical, electrochemical, nonlinear optical, excited state dynamics studies

2014 ◽  
Vol 2 (9) ◽  
pp. 1711-1722 ◽  
Author(s):  
Debasis Swain ◽  
Radhakant Singh ◽  
Varun Kumar Singh ◽  
Narra Vamsi Krishna ◽  
Lingamallu Giribabu ◽  
...  
Keyword(s):  
Excited State ◽  
Nonlinear Optical ◽  
Excited State Dynamics ◽  
Sterically Demanding ◽  
Sterically Hindered

Sterically hindered molecules like the title compounds, combined with their strong NLO coefficients make them potential candidates for photonic applications.

Thermodynamics of metal-ligand bond formation. III. Adducts of heterocyclic bases with Bis(N-nitroso-N-phenylhydroxylaminato)copper(II)

1971 ◽  
Vol 24 (11) ◽  
pp. 2267 ◽  
Author(s):  
DP Graddon ◽  
CY Hsu
Keyword(s):  
Steric Hindrance ◽  
Benzene Solution ◽  
Bond Formation ◽  
Adduct Formation ◽  
Thermometric Titration ◽  
Sterically Hindered ◽  
Heterocyclic Bases ◽  
Metal Ligand ◽  
Ligand Bond

The copper(II) complex of N-nitroso-N-phenylhydroxylamine (copper cupferrate) reacts with heterocyclic bases in benzene solution to form 1 : 1-adducts. Enthalpies and entropies of adduct formation with a range of bases have been determined by thermometric titration. The results, which are similar to those obtained with copper(II) complexes of β-diketones, reveal two isoequilibrium series for sterically hindered and unhindered bases, and indicate that the effect of the steric hindrance is probably to restrict rotation of the base molecule about the newly formed metal-ligand bond.

ChemInform Abstract: A Protocol for Amide Bond Formation with Electron Deficient Amines and Sterically Hindered Substrates.

ChemInform ◽  
2016 ◽  
Vol 47 (20) ◽  
Author(s):  
Maria E. Due-Hansen ◽  
Sunil K. Pandey ◽  
Elisabeth Christiansen ◽  
Rikke Andersen ◽  
Steffen V. F. Hansen ◽  
...  
Keyword(s):  
Bond Formation ◽  
Amide Bond ◽  
Amide Bond Formation ◽  
Sterically Hindered

Stepwise approach for sterically hindered Csp3–Csp3 bond formation by dehydrogenative O-alkylation and Lewis acid-catalyzed [1,3]-rearrangement towards the arylalkylcyclopentane skeleton of sesquiterpenes

2020 ◽  
Vol 56 (25) ◽  
pp. 3621-3624
Author(s):  
Ban Fujitani ◽  
Kengo Hanaya ◽  
Takeshi Sugai ◽  
Shuhei Higashibayashi
Keyword(s):  
Lewis Acid ◽  
Bond Formation ◽  
Cross Coupling ◽  
Coupling Method ◽  
Stepwise Approach ◽  
Acid Catalyzed ◽  
Sterically Hindered

A stepwise dehydrogenative cross-coupling method was developed for the formation of sterically hindered Csp3–Csp3 bonds.

scholarly journals Stereoselective construction of sterically hindered oxaspirocycles via chiral bidentate directing group-mediated C(sp3)–O bond formation

2018 ◽  
Vol 9 (6) ◽  
pp. 1473-1480 ◽  
Author(s):  
Yechan Kim ◽  
Seoung-Tae Kim ◽  
Dahye Kang ◽  
Te-ik Sohn ◽  
Eunyoung Jang ◽  
...  
Keyword(s):  
Bond Formation ◽  
Directing Group ◽  
Sterically Hindered

A new, bidentate, chiral directing group derived from 2,2-dimethyl-1-(pyridin-2-yl)propan-1-amine was discovered, which enables stereoselective palladium(ii)-catalyzed intramolecular C(sp3)–O bond formation.

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