A dual modality99mTc/Re(i)-labelled T140 analogue for imaging of CXCR4 expression

2019 ◽  
Vol 17 (3) ◽  
pp. 598-608 ◽  
Author(s):  
William L. Turnbull ◽  
Lihai Yu ◽  
Emily Murrell ◽  
Mark Milne ◽  
Carlie L. Charron ◽  
...  

A T140-derived peptide conjugated with a naphthalimide fluorophore/chelator was coordinated to rhenium or technetium-99m to image CXCR4 expression by fluorescence microscopy or SPECT imaging.

2009 ◽  
Vol 25 (4) ◽  
pp. 192-200 ◽  
Author(s):  
S. Shcherbinin ◽  
A. Celler ◽  
M. Trummer ◽  
T. Humphries

2019 ◽  
Vol 72-73 ◽  
pp. S65
Author(s):  
J. Walsh ◽  
L. Francesconi ◽  
V. Sanders ◽  
D. Iskhakov ◽  
B. Zeglis ◽  
...  

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Seyedeh Masoumeh Ghoreishi ◽  
Atena Najdian ◽  
Sina Yadegari ◽  
Mohammad Seyedhamzeh ◽  
Maziyar Etemadzade ◽  
...  

Even today, technetium-99m is a radionuclide choice for diagnostic in nuclear medicine. The unique chemical and physical properties of technetium-99m make it suitable as an available radionuclide in many centers. In this study, we examined the potential of CQD as a reducing agent in the MDP kit. Citric acid-derived CQD was synthesized and confirmed by FT-IR, TEM, UV-Vis, XPS, and surface analysis. No cytotoxicity was observed by the MTT assay. They were reducing properties of the CQD confirmed by fluorescence microscopy. The MDP kit is prepared by evaluating different parameters that affect the radiolabeling yield, including ligand, time, and CQD. The optimum amount of each parameter is obtained by Box–Behnken software. Finally, fluorescent spectroscopy, SPECT imaging, and biodistribution study showed that CQD reduces technetium-99m. Accumulation of radiotracer in the femur showed that CQD could be used in a radiopharmaceutical kit.


1997 ◽  
Vol 40 (12) ◽  
pp. 1835-1844 ◽  
Author(s):  
Peter C. Meltzer ◽  
Paul Blundell ◽  
Alun G. Jones ◽  
Ashfaq Mahmood ◽  
Basem Garada ◽  
...  

2009 ◽  
Vol 2 (1) ◽  
pp. 70-76 ◽  
Author(s):  
Hajime Monzen ◽  
Masatake Hara ◽  
Akira Nakanishi ◽  
Makoto Hirata ◽  
Takatoshi Suzuki ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document