Copper-catalyzed oxidative multicomponent reaction: synthesis of imidazo fused heterocycles with molecular oxygen

2018 ◽  
Vol 16 (39) ◽  
pp. 7143-7151 ◽  
Author(s):  
Xianwei Li ◽  
Tianzhang Wang ◽  
Yu-Jing Lu ◽  
Shaomin Ji ◽  
Yanping Huo ◽  
...  
Keyword(s):  
Molecular Oxygen ◽  
Multicomponent Reaction ◽  
Reaction Synthesis ◽  
Terminal Alkyne ◽  
Fused Heterocycles ◽  
Allylic Bromide

An oxidative cascade that involves multicomponent reaction comprising a terminal alkyne, 2-amino N-heterocycle, benzyl or allylic bromide with molecular oxygen, delivering densely functionalized imidazo fused heterocycles, is achieved.

Copper-Catalyzed Multicomponent Reaction: Synthesis of 4-Arylsulfonylimino-4,5-dihydrofuran Derivatives

2010 ◽  
Vol 75 (16) ◽  
pp. 5743-5745 ◽  
Author(s):  
Yongjia Shang ◽  
Kai Ju ◽  
Xinwei He ◽  
Jinsong Hu ◽  
Shuyan Yu ◽  
...  
Keyword(s):  
Multicomponent Reaction ◽  
Reaction Synthesis

Efficient Multicomponent Reaction Synthesis of the Schistosomiasis Drug Praziquantel

2010 ◽  
Vol 16 (41) ◽  
pp. 12296-12298 ◽  
Author(s):  
Haiping Cao ◽  
Haixia Liu ◽  
Alexander Dömling
Keyword(s):  
Multicomponent Reaction ◽  
Reaction Synthesis

ChemInform Abstract: Copper-Catalyzed Multicomponent Reaction: Synthesis of 4-Arylsulfonylimino-4,5-dihydrofuran Derivatives.

ChemInform ◽  
2010 ◽  
Vol 41 (51) ◽  
pp. no-no
Author(s):  
Yongjia Shang ◽  
Kai Ju ◽  
Xinwei He ◽  
Jinsong Hu ◽  
Shuyan Yu ◽  
...  
Keyword(s):  
Multicomponent Reaction ◽  
Reaction Synthesis

Copper-Catalyzed Efficient Multicomponent Reaction: Synthesis of Benzoxazoline-Amidine Derivatives

2009 ◽  
Vol 351 (16) ◽  
pp. 2709-2713 ◽  
Author(s):  
Yongjia Shang ◽  
Xinwei He ◽  
Jinsong Hu ◽  
Jianwei Wu ◽  
Min Zhang ◽  
...  
Keyword(s):  
Multicomponent Reaction ◽  
Reaction Synthesis

N-(Chlorobenzyl) Formamide as an Antituberculosis Agent from Multicomponent Reaction Synthesis

2021 ◽  
pp. 3253-3261
Author(s):  
Desy Ayu Irma Permatasari ◽  
Ritmaleni Ritmaleni ◽  
Titik Nuryastuti
Keyword(s):  
Multicomponent Reaction ◽  
Positive Control ◽  
Reaction Synthesis ◽  
Antituberculosis Activity ◽  
Alamar Blue ◽  
Target Compound ◽  
Reaction Method ◽  
Mycobacterium Tuberculosis H37rv ◽  
H37rv Strain ◽  
Concentration Series

Tuberculosis (TB) is an infectious disease caused by M. tuberculosis. A new series of four benzylformamide with chloro substitution were synthesized by multicomponent reaction method and screened for antituberculosis activity against Mycobacterium tuberculosis H37Rv strain. This study was based on amidoalkylation reaction of aromatic-aldehyde, formamide and formic acid at 150oC to give a good yield of benzylformamide. Target compound were isolated, purificated, identified and characterized by GC-MS, FTIR, 1H-NMR, and 13C-NMR then the antituberculosis activity was examined by Microplate Alamar Blue Assay (MABA) and Middlebrook 7H9-7H11 medium in concentration series of 1000 – 1,954 μg/mL, and isoniazid as a positive control. Among the three derivative, N-(2,4-dichlorobenzyl) formamide has the most potential antituberculosis activity up to 500.0 L/mL.

The Borono–Strecker Reaction: Synthesis of α-Aminoboronates via a Multicomponent Reaction of Carbonyl Compounds, Amines, and B2pin2

2019 ◽  
Vol 22 (2) ◽  
pp. 365-370 ◽  
Author(s):  
Wenbo Ming ◽  
Xiaocui Liu ◽  
Alexandra Friedrich ◽  
Johannes Krebs ◽  
Todd B. Marder
Keyword(s):  
Multicomponent Reaction ◽  
Carbonyl Compounds ◽  
Reaction Synthesis ◽  
Strecker Reaction

An efficient synthesis of novel dibenzoxdiazepine-fused heterocycles through a multicomponent reaction

RSC Advances ◽  
2014 ◽  
Vol 4 (92) ◽  
pp. 50947-50949 ◽  
Author(s):  
Zhiwei Qian ◽  
Anjiang Yang ◽  
Weiteng An ◽  
Ting Yu ◽  
Xin Wang ◽  
...  
Keyword(s):  
Multicomponent Reaction ◽  
Efficient Synthesis ◽  
One Pot ◽  
One Pot Synthesis ◽  
Fused Heterocycles ◽  
Three Component Reaction

A one-pot synthesis of 6-oxa-2,2a1,11-triazadibenzo[cd,g]azulenes by a three-component reaction of a 2-aminoheterocycle, aldehydes, and 2-isocyanophenyl acetate is presented.

scholarly journals Cysteine Isocyanide in Multicomponent Reaction: Synthesis of Peptido-Mimetic 1,3-Azoles

2017 ◽  
Vol 82 (18) ◽  
pp. 9585-9594 ◽  
Author(s):  
Thimmalapura M. Vishwanatha ◽  
Katarzyna Kurpiewska ◽  
Justyna Kalinowska-Tłuścik ◽  
Alexander Dömling
Keyword(s):  
Multicomponent Reaction ◽  
Reaction Synthesis
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