Direct C-4 alkylation of quinazoline N-oxides with ethers via an oxidative cross-coupling reaction under metal-free conditions

2018 ◽  
Vol 16 (45) ◽  
pp. 8724-8731 ◽  
Author(s):  
Qin Yang ◽  
Minhao Lou ◽  
Zhijian Yin ◽  
Zhihong Deng ◽  
Qiuping Ding ◽  
...  
Keyword(s):  
Oxidative Coupling ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Metal Free ◽  
Cross Coupling Reaction

A novel and efficient protocol for the direct C-4 alkylation of quinazoline-3-oxides via radical oxidative coupling between quinazoline 3-oxides and ethers in the presence of TBHP is presented.

Metal-free oxidative coupling of quinoxalin-2(1H)-ones with arylaldehydes leading to 3-acylated quinoxalin-2(1H)-ones

2018 ◽  
Vol 16 (17) ◽  
pp. 3203-3212 ◽  
Author(s):  
Jin-Wei Yuan ◽  
Jun-Hao Fu ◽  
Shuai-Nan Liu ◽  
Yong-Mei Xiao ◽  
Pu Mao ◽  
...  
Keyword(s):  
Oxidative Coupling ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Metal Free ◽  
Aryl Aldehydes ◽  
Mild Conditions ◽  
Cross Coupling Reaction

An efficient protocol for the synthesis of 3-aroylquinoxalin-2(1H)-ones has been developed via a metal-free oxidative cross-coupling reaction of quinoxalin-2(1H)-ones with aryl aldehydes under mild conditions with good yields.

ChemInform Abstract: A Transition-Metal-Free Cross-Coupling Reaction of Allylic Bromides with Aryl- and Vinylboronic Acids.

ChemInform ◽  
2012 ◽  
Vol 43 (33) ◽  
pp. no-no
Author(s):  
Mitsuhiro Ueda ◽  
Kota Nishimura ◽  
Ryo Kashima ◽  
Ilhyong Ryu
Keyword(s):  
Transition Metal ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Metal Free ◽  
Cross Coupling Reaction

ChemInform Abstract: Selective Synthesis of Partially Protected Nonsymmetric Biphenols by Reagent- and Metal-Free Anodic Cross-Coupling Reaction.

ChemInform ◽  
2016 ◽  
Vol 47 (52) ◽  
Author(s):  
Anton Wiebe ◽  
Dieter Schollmeyer ◽  
Katrin M. Dyballa ◽  
Robert Franke ◽  
Siegfried R. Waldvogel
Keyword(s):  
Coupling Reaction ◽  
Cross Coupling ◽  
Selective Synthesis ◽  
Metal Free ◽  
Cross Coupling Reaction

Transition metal-free tandem pyridinyl–allyl–allyl cross-coupling reaction

2017 ◽  
Vol 47 (18) ◽  
pp. 1668-1675 ◽  
Author(s):  
Lili Zhang ◽  
Zhengkai Chen ◽  
Hongli Li ◽  
Wenguang Yin ◽  
Jianfeng Xu ◽  
...  
Keyword(s):  
Transition Metal ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Metal Free ◽  
Cross Coupling Reaction

An Iodide-Mediated Transition-Metal-Free Strategy towards Unsymmetrical Diaryl Sulfides via Arylhydrazines and Thiols

Synthesis ◽  
2019 ◽  
Vol 52 (05) ◽  
pp. 727-734 ◽  
Author(s):  
Farnaz Jafarpour ◽  
Mohammad Asadpour ◽  
Meysam Azizzade ◽  
Mehran Ghasemi ◽  
Saideh Rajai-Daryasarei
Keyword(s):  
Transition Metal ◽  
Room Temperature ◽  
Bond Formation ◽  
Antidepressant Drug ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Potential Utility ◽  
Metal Free ◽  
Cross Coupling Reaction ◽  
High Yields

A mild, scalable iodine-mediated oxidative cross-coupling reaction of arylhydrazines and thiols for construction of thioethers (sulfides) in the absence of any transition metals or photocatalysts is disclosed. A variety of unsymmetrical diaryl sulfides with broad substrate scope both on thiols and hydrazines were synthesized in high yields in water at room temperature. Furthermore, to demonstrate the utility of the protocol, the above C–S bond formation was applied in the synthesis of the key structure of vortioxetine as an antidepressant drug. The gram-scale outcome also added to the potential utility of this protocol.

ChemInform Abstract: Metal-Free Cross-Coupling Reaction of Aldehydes with Disulfides by Using DTBP as an Oxidant under Solvent-Free Conditions.

ChemInform ◽  
2014 ◽  
Vol 45 (37) ◽  
pp. no-no
Author(s):  
Jing-Wen Zeng ◽  
Yi-Chen Liu ◽  
Ping-An Hsieh ◽  
Yu-Ting Huang ◽  
Chih-Lun Yi ◽  
...  
Keyword(s):  
Coupling Reaction ◽  
Cross Coupling ◽  
Solvent Free ◽  
Metal Free ◽  
Cross Coupling Reaction ◽  
Solvent Free Conditions

Metal-free cross-coupling reaction of aldehydes with disulfides by using DTBP as an oxidant under solvent-free conditions

2014 ◽  
Vol 16 (5) ◽  
pp. 2644-2652 ◽  
Author(s):  
Jing-Wen Zeng ◽  
Yi-Chen Liu ◽  
Ping-An Hsieh ◽  
Yu-Ting Huang ◽  
Chih-Lun Yi ◽  
...  
Keyword(s):  
Functional Group ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Solvent Free ◽  
Metal Free ◽  
Cross Coupling Reaction ◽  
Solvent Free Conditions

A DTBP-promoted C–H thiolation of aldehydes with disulfides under metal-free and solvent-free conditions is described. The system shows good functional group tolerance to afford thioesters in moderate to excellent yields.

Synthesis of Carbodiimides by I2/CHP-Mediated Cross-Coupling Reaction of Isocyanides with Amines under Metal-Free Conditions

2015 ◽  
Vol 17 (8) ◽  
pp. 1974-1977 ◽  
Author(s):  
Tong-Hao Zhu ◽  
Shun-Yi Wang ◽  
Yang-Qing Tao ◽  
Shun-Jun Ji
Keyword(s):  
Coupling Reaction ◽  
Cross Coupling ◽  
Metal Free ◽  
Cross Coupling Reaction
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