Valdecoxib vs. borazavaldecoxib: isoxazole BN/CC isosterism as a case study in designing and stabilizing boron heterocycles

2018 ◽  
Vol 16 (26) ◽  
pp. 4849-4856
Author(s):  
Michele Boghi ◽  
Dennis G. Hall
Keyword(s):  
Hydrolytic Stability ◽  
Comprehensive Study ◽  
Boron Heterocycles

A comprehensive study on the preparation, hydrolytic stability, and the structural and spectrophotometric properties of 1,2,4,5-oxadiazaboroles is presented by way of a comparison between the NSAID drug valdecoxib (1) and its unprecedented B–N isostere, borazavaldecoxib (2).

Role efficacy: A comprehensive study

2018 ◽  
Vol 9 (01) ◽  
Author(s):  
Gopa Bhardwaj ◽  
Swati Sharma ◽  
Neeti B. Karnick
Keyword(s):  
Personal Growth ◽  
Role Models ◽  
Qualitative Approach ◽  
Potential Effectiveness ◽  
Role Integration ◽  
Helping Relationship ◽  
Role Efficacy ◽  
Comprehensive Study

A case study in manufacturing giant attempts to capture how potential effectiveness of a role is psychologically tuned along ten dimensions on which efficacy of an employee is defined. Further, how position, age and tenure of employment interact with role efficacy. A combination of quantitative and qualitative approach is followed, where n=28. Managers are seen as leaders and act like role models for the subordinates. Further, managers are high on helping relationship. Both see an opportunity for personal growth in their role. Self- role integration is lesser in managers than subordinates. Subordinates are found to be more reactive. Confrontation is greater for subordinates than managers. Elders are strong on dimensions common to achievers and youngest seems to have politics. Longer tenures exhibits more helping attitude and more confrontation than with smaller tenures. Thus, the dynamism between position, age and tenure seems to have an effect on role-efficacy.

scholarly journals Law Enforcement Response To Human Trafficking According To Law No. 21/2007: Case Study in Benjina, Aru Archipelago Regency

2018 ◽  
Vol 5 (2-1) ◽  
Author(s):  
Ahmad Ali Fikri Pandela ◽  
Anhar Ansyory ◽  
Ulfatmi Ulfatmi
Keyword(s):  
Law Enforcement ◽  
Human Trafficking ◽  
Organized Crime ◽  
Legal Basis ◽  
Peace Officer ◽  
Comprehensive Study

Generally, there are some distinction on the response to human trafficking that has been particularly ruled in Law No.20/2007 21 about Abolition of Criminal Act Human Trafficking. That law contains legal basis to anticipate and round up activities, ways, or any other exploitations occured on human trafficking. In the process of implementation of criminal act case handling to human trafficking, the peace officer sometimes get difficulties to proof the perpetrator because sometimes it’s an organized crime, moreover it is a trans-national crime. The purpose of this study is to know and to analyze some aspects in law enforcement on human trafficking cases in Indonesia according to Law No. 21/2007 about Abolition of Criminal Act Human Trafficking (case study on human trafficking case in Benjina, Aru Archipelago Regency, and Maluku). So that this study can be a common comprehensive study to handle the human trafficking cases in Indonesia.

From Android Bug Reports to Android Bug Handling Process

2016 ◽  
Vol 7 (4) ◽  
pp. 1-18
Author(s):  
Liguo Yu
Keyword(s):  
Project Management ◽  
Open Source ◽  
Tracking System ◽  
Software Project ◽  
Bug Reports ◽  
Bug Report ◽  
Bug Tracking ◽  
Android Development ◽  
Comprehensive Study

Android is an operating system for mobile devices. Its development is led by Google and some other companies. Because of the open-source property of Android, anyone can report a bug through its online bug tracking system. In this paper, we analyze the bug reports of Android operating systems. Specifically, through this study, we would like to answer the following questions regarding Android development and its project management: (1) Could Android bug reports be handled on time? (2) What is the distribution of different maintenance activities initiated by Android bug reports? (3) How long does it take to handle an Android bug report? (4) Are the number of followers and the number of following messages of an Android bug report related to the effort spent on handling this bug report? Through answering these questions, this paper presents a comprehensive study of Android bug reporting and handling process. The information and knowledge obtained through this case study could help us better understand open-source software project, such as its development process and project management.

scholarly journals Introducing an innovation promotion model for construction projects

2020 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Sam Fernando ◽  
Kriengsak Panuwatwanich ◽  
David Thorpe
Keyword(s):  
Literature Review ◽  
Construction Projects ◽  
Complex Dynamics ◽  
Relationship Enhancement ◽  
Content Type ◽  
Study Approach ◽  
Project Outcomes ◽  
First Time ◽  
Comprehensive Study

PurposeThis study aims to investigate and model the complex dynamics of innovation enablers in construction projects aiming to develop a framework identifying actions for clients to promote innovation.Design/methodology/approachThrough a comprehensive literature review, a conceptual model was previously derived to explain the client-driven enablers in promoting innovation. This was tested using the data from 131 Australian construction projects. Statistical analysis was conducted on the data using factor analysis and correlation analysis to test the model, which was validated using the case study approach. The testing and validating aspects are explained in this paper.FindingsThe constructs of the recommended model are idea harnessing, relationship enhancement, incentivization and project team fitness.Research limitations/implicationsThe difficulty of analyzing the complex dynamics happening within projects in relation to innovation has been a barrier to progress research in this area. The introduction of this model would pave the way for researchers to explore this area with ease.Originality/valueAs revealed in the detailed literature review undertaken, this is the first time that a comprehensive study has been conducted to identify client-led innovation enablers for construction projects. The results would benefit industry practitioners to achieve enhanced project outcomes in construction projects through innovation.

Handel's Recomposed Return Arias and Romantic Attraction in Alexander Balus

2016 ◽  
Vol 69 (3) ◽  
pp. 651-698
Author(s):  
David Ross Hurley
Keyword(s):  
Romantic Attraction ◽  
Ternary Form ◽  
The Subject ◽  
Comprehensive Study

Among the various formal structures employed in the arias of Handel's oratorios is a ternary form in which the last section is newly written, rather than being a verbatim repeat of the first section, as in the ubiquitous da capo aria. This form, for which I propose the term “recomposed return aria,” is rarely mentioned by scholars, and has never been the subject of a comprehensive study, despite its considerable aesthetic interest. In this article I focus on Handel's use of the recomposed return aria, exploring in particular the array of recapitulatory designs that it encompasses, and the reasons why Handel may sometimes have chosen this form instead of the regular da capo. I then turn to the oratorio Alexander Balus, as a case study through which to show how the compositional freedom intrinsic to the recomposed return aria allows for the portrayal of various aspects of erotic attraction experienced by the protagonists.

scholarly journals The Historical Soundscape Analysis of Fatahillah Square, Jakarta

Acoustics ◽  
2020 ◽  
Vol 2 (4) ◽  
pp. 847-867
Author(s):  
Michael Isnaeni Djimantoro ◽  
Widjaja Martokusumo ◽  
Heru W. Poerbo ◽  
R. Joko Sarwono
Keyword(s):  
Cultural Heritage ◽  
Visual Analysis ◽  
Sound Sources ◽  
The Past ◽  
Holistic Understanding ◽  
Sonic Environment ◽  
The 19Th Century ◽  
Comprehensive Study

Understanding conceptions of the protection of cultural heritage continues to develop until now. Presently, urban historic places are not only comprehended as tangible but also include intangible dimensions. However, the conservation of cultural heritage dominantly still emphasises the visual sense more than any other senses. Thus, this paper addressed several questions on the role of human senses, the historic sonic environments, and the soundmarks of the past in examining a historical area. This paper aims to reveal the relation between sound sources and its predicted sonic environment in historic places over the time. The case study was Fatahillah Square, Jakarta, which has been documented from the 19th century until now. Some methods were carried out such as soundwalk, recalled in memory, and visual analysis. The results show that comprehensive study of multisensorial stimulus can increase a holistic understanding of historic places. Therefore, the protection of historic sites cannot only focus on the object per se, but also it must be considered to be a holistic entity. This research highlights new perspectives in analysing historical areas using combination of pictorial sources and sonic information.

scholarly journals Transparency order versus confusion coefficient: a case study of NIST lightweight cryptography S-Boxes

Cybersecurity ◽  
2021 ◽  
Vol 4 (1) ◽  
Author(s):  
Huizhong Li ◽  
Guang Yang ◽  
Jingdian Ming ◽  
Yongbin Zhou ◽  
Chengbin Jin
Keyword(s):  
The Other ◽  
Side Channel ◽  
Side Channel Attacks ◽  
Lightweight Cryptography ◽  
Security Assurance ◽  
Channel Resistance ◽  
Cryptographic Algorithms ◽  
Transparency Order ◽  
Comprehensive Study

AbstractSide-channel resistance is nowadays widely accepted as a crucial factor in deciding the security assurance level of cryptographic implementations. In most cases, non-linear components (e.g. S-Boxes) of cryptographic algorithms will be chosen as primary targets of side-channel attacks (SCAs). In order to measure side-channel resistance of S-Boxes, three theoretical metrics are proposed and they are reVisited transparency order (VTO), confusion coefficients variance (CCV), and minimum confusion coefficient (MCC), respectively. However, the practical effectiveness of these metrics remains still unclear. Taking the 4-bit and 8-bit S-Boxes used in NIST Lightweight Cryptography candidates as concrete examples, this paper takes a comprehensive study of the applicability of these metrics. First of all, we empirically investigate the relations among three metrics for targeted S-boxes, and find that CCV is almost linearly correlated with VTO, while MCC is inconsistent with the other two. Furthermore, in order to verify which metric is more effective in which scenarios, we perform simulated and practical experiments on nine 4-bit S-Boxes under the non-profiled attacks and profiled attacks, respectively. The experiments show that for quantifying side-channel resistance of S-Boxes under non-profiled attacks, VTO and CCV are more reliable while MCC fails. We also obtain an interesting observation that none of these three metrics is suitable for measuring the resistance of S-Boxes against profiled SCAs. Finally, we try to verify whether these metrics can be applied to compare the resistance of S-Boxes with different sizes. Unfortunately, all of them are invalid in this scenario.

The Rise of Food Charity in Europe

2020 ◽  
Keyword(s):  
Social Policy ◽  
Driving Forces ◽  
National Context ◽  
Policy Makers ◽  
Policy Perspective ◽  
The United Kingdom ◽  
Food Charity ◽  
Practical Implications ◽  
Comprehensive Study

This edited collection provides the first comprehensive study of the rise of food charity across Europe. Bringing together leading researchers across the continent, this collection explores the driving forces behind this phenomenon and its implications into the future, from a social policy perspective. The book incorporates cases studies from Finland, Germany, Italy, the Netherlands, Slovenia, Spain and the United Kingdom. Each empirical case study chapter explores: the histories of food charity in the national context; key changes in social policy and their relationship to food charity; and the implications for social justice. The result is the first book to offer a systematic comparative study of the rise of food charity across Europe. It provides urgently needed evidence on these trends which will be of use to academics, policy makers and practitioners who are grappling with the practical implications of these phenomena.

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