Regio- and stereospecific Friedel–Crafts alkylation of indoles with spiro-epoxyoxindoles
2018 ◽
Vol 16
(19)
◽
pp. 3655-3661
◽
A highly efficient strategy for the regio- and stereospecific Friedel–Crafts alkylation of indoles with spiro-epoxyoxindoles has been developed in the mixed solvents of HFIP/H2O (1 : 9) without the use of catalysts.