Trithiazolyl-1,3,5-triazines bearing decyloxybenzene moieties: synthesis, photophysical and electrochemical properties, and self-assembly behavior

2018 ◽  
Vol 16 (19) ◽  
pp. 3584-3595 ◽  
Author(s):  
Shin-ichiro Kato ◽  
Satoshi Jin ◽  
Terutaka Kimura ◽  
Naoki Yoshikawa ◽  
Daiki Nara ◽  
...  
Keyword(s):  
Electrochemical Properties ◽  
Self Assembly ◽  
Self Assembling ◽  
Assembly Behavior

We synthesized the first members of trithiazolyl-1,3,5-triazines that combine attractive photophysical and self-assembling properties.

scholarly journals On the Aqueous Solution Behavior of C-Substituted 3,1,2-Ruthenadicarbadodecaboranes

Inorganics ◽  
2019 ◽  
Vol 7 (7) ◽  
pp. 91 ◽  
Author(s):  
Marta Gozzi ◽  
Benedikt Schwarze ◽  
Peter Coburger ◽  
Evamarie Hey-Hawkins
Keyword(s):  
Aqueous Solution ◽  
Aqueous Solutions ◽  
Self Assembly ◽  
Self Assembling ◽  
Vis Spectroscopy ◽  
Assembly Behavior ◽  
Biological Performance ◽  
Type 3

3,1,2-Ruthenadicarbadodecaborane complexes bearing the [C2B9H11]2− (dicarbollide) ligand are robust scaffolds, with exceptional thermal and chemical stability. Our previous work has shown that these complexes possess promising anti-tumor activities in vitro, and tend to form aggregates (or self-assemblies) in aqueous solutions. Here, we report on the synthesis and characterization of four ruthenium(II) complexes of the type [3-(η6-arene)-1,2-R2-3,1,2-RuC2B9H9], bearing either non-polar (R = Me (2–4)) or polar (R = CO2Me (7)) substituents at the cluster carbon atoms. The behavior in aqueous solution of complexes 2, 7 and the parent unsubstituted [3-(η6-p-cymene)-3,1,2-RuC2B9H11] (8) was investigated via UV-Vis spectroscopy, mass spectrometry and nanoparticle tracking analysis (NTA). All complexes showed spontaneous formation of self-assemblies (108–109 particles mL−1), at low micromolar concentration, with high polydispersity. For perspective applications in medicine, there is thus a strong need for further characterization of the spontaneous self-assembly behavior in aqueous solutions for the class of neutral metallacarboranes, with the ultimate scope of finding the optimal conditions for exploiting this self-assembling behavior for improved biological performance.

Synthesis, Photophysical and Electrochemical Properties, and Self-assembly Behavior of Two Hexaazatriphenylene Derivatives: A Single Bond Makes a Big Difference

2016 ◽  
Vol 11 (6) ◽  
pp. 839-843 ◽  
Author(s):  
Cheng Qian ◽  
Wei-Hao Zhao ◽  
Yuan Tian ◽  
Guo-Fang Jiang ◽  
Tian-Guang Zhan ◽  
...  
Keyword(s):  
Electrochemical Properties ◽  
Self Assembly ◽  
Single Bond ◽  
Assembly Behavior

scholarly journals Review of Contemporary Self-Assembled Systems for the Controlled Delivery of Therapeutics in Medicine

Nanomaterials ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 278
Author(s):  
Laura Osorno ◽  
Alyssa Brandley ◽  
Daniel Maldonado ◽  
Alex Yiantsos ◽  
Robert Mosley ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Deep Understanding ◽  
Drug Bioavailability ◽  
Medical Needs ◽  
Self Assembling ◽  
Amphiphilic Molecules ◽  
Self Assembled ◽  
Assembly Behavior ◽  
External Stimuli

The novel and unique design of self-assembled micro and nanostructures can be tailored and controlled through the deep understanding of the self-assembly behavior of amphiphilic molecules. The most commonly known amphiphilic molecules are surfactants, phospholipids, and block copolymers. These molecules present a dual attraction in aqueous solutions that lead to the formation of structures like micelles, hydrogels, and liposomes. These structures can respond to external stimuli and can be further modified making them ideal for specific, targeted medical needs and localized drug delivery treatments. Biodegradability, biocompatibility, drug protection, drug bioavailability, and improved patient compliance are among the most important benefits of these self-assembled structures for drug delivery purposes. Furthermore, there are numerous FDA-approved biomaterials with self-assembling properties that can help shorten the approval pathway of efficient platforms, allowing them to reach the therapeutic market faster. This review focuses on providing a thorough description of the current use of self-assembled micelles, hydrogels, and vesicles (polymersomes/liposomes) for the extended and controlled release of therapeutics, with relevant medical applications. FDA-approved polymers, as well as clinically and commercially available nanoplatforms, are described throughout the paper.

The Preparation of Comb Polymer Rotaxanes and Study on their Self-Assembly Behavior

2016 ◽  
Vol 852 ◽  
pp. 653-656
Author(s):  
Li Sun ◽  
Lin Zhu ◽  
Jun Peng Xie ◽  
Rui Fang Guan
Keyword(s):  
Self Assembly ◽  
Inclusion Compound ◽  
Life Science ◽  
Molecular Assembly ◽  
The Self ◽  
X Ray Diffraction ◽  
X Ray ◽  
H Nmr ◽  
Self Assembling ◽  
Assembly Behavior

It is very important to form a stable, structure-controlled material by molecular assembly inthe fields of materials and life science. How cyclodextrins affect the self–assembly behavior of inclusion compounds becomes the focus recently, due to the advantages of selectivity, regulating, capability, biocompatibility and other interesting properties. In thispaper, polyoxyethylene ω-tristyrylphenyl methacrylate (SEM-25) and α-cyclodextrin (α-CD) form inclusion compound (AS) firstly, then copolymer of AS and methyl methacrylate (MMA) - the comb-like polyrotaxanes (CD-PR) were prepared through the redox initiationsystem of free radical polymerization. Furthermore, the self-assembling behavior of CD-PR is studied, it is found that solvent has an great impact on aggregation morphology of CD-PR without changing composition of the polyrotaxanes. Products were characterized by X-ray diffraction (XRD), nuclear magnetic resonance (1H NMR) and scanning electron microscope (SEM).

scholarly journals Septipyridines as conformationally controlled substitutes for inaccessible bis(terpyridine)-derived oligopyridines in two-dimensional self-assembly

2011 ◽  
Vol 2 ◽  
pp. 405-415 ◽  
Author(s):  
Daniel Caterbow ◽  
Daniela Künzel ◽  
Michael G Mavros ◽  
Axel Groß ◽  
Katharina Landfester ◽  
...  
Keyword(s):  
Self Assembly ◽  
Pyrolytic Graphite ◽  
Scanning Tunneling ◽  
Strong Impact ◽  
Tunneling Microscopy ◽  
New Class ◽  
Self Assembling ◽  
Assembly Behavior ◽  
Structure Calculations ◽  
Transoid Conformation

The position of the peripheral nitrogen atoms in bis(terpyridine)-derived oligopyridines (BTPs) has a strong impact on their self-assembly behavior at the liquid/HOPG (highly oriented pyrolytic graphite) interface. The intermolecular hydrogen bonding interactions in these peripheral pyridine units show specific 2D structures for each BTP isomer. From nine possible constitutional isomers only four have been described in the literature. The synthesis and self-assembling behavior of an additional isomer is presented here, but the remaining four members of the series are synthetically inaccessible. The self-assembling properties of three of the missing four BTP isomers can be mimicked by making use of the energetically preferred N–C–C–N transoid conformation between 2,2'-bipyridine subunits in a new class of so-called septipyridines. The structures are investigated by scanning tunneling microscopy (STM) and a combination of force-field and first-principles electronic structure calculations.

Bioinspired Artificial Protein Materials: Self-Assembly and Order from Nano to Macroscale

2011 ◽  
Vol 1301 ◽  
Author(s):  
Min Dai ◽  
Jennifer S. Haghpanah ◽  
Carlo Yuvienco ◽  
Jin Kim Montclare
Keyword(s):  
Self Assembly ◽  
Matrix Protein ◽  
Coiled Coil ◽  
Supramolecular Assembly ◽  
Stimuli Responsive ◽  
Block Polymers ◽  
Self Assembling ◽  
Assembly Behavior ◽  
Protein Block

ABSTRACTWe describe the biosynthesis and characterization of protein materials comprised of two distinct self-assembling domains (SADs): elastin (E) found in tissue for its elastic properties and cartilage oligomeric matrix protein coiled-coil (COMPcc, C) predominantly locatedin joint and in bones. Based on earlier studies on protein block polymers comprised these two SADs, orientation and number of blocks play a crucial role in the overall stimuli-responsive supramolecular assembly behavior. Here we fabricate a range of EnC and CEn block polymers in which the E domain is systematically truncated to explore the effects of the E domain on the overall physicochemical behavior.

Factors Affecting Molecular Self-Assembly and Its Mechanism

2012 ◽  
Vol 9 (1) ◽  
pp. 43 ◽  
Author(s):  
Hueyling Tan
Keyword(s):  
Self Assembly ◽  
Building Blocks ◽  
Molecular Engineering ◽  
Molecular Structures ◽  
Polymer Science ◽  
New Approach ◽  
Factors Affecting ◽  
Dna Structures ◽  
Self Assembling ◽  
Wide Range

Molecular self-assembly is ubiquitous in nature and has emerged as a new approach to produce new materials in chemistry, engineering, nanotechnology, polymer science and materials. Molecular self-assembly has been attracting increasing interest from the scientific community in recent years due to its importance in understanding biology and a variety of diseases at the molecular level. In the last few years, considerable advances have been made in the use ofpeptides as building blocks to produce biological materials for wide range of applications, including fabricating novel supra-molecular structures and scaffolding for tissue repair. The study ofbiological self-assembly systems represents a significant advancement in molecular engineering and is a rapidly growing scientific and engineering field that crosses the boundaries ofexisting disciplines. Many self-assembling systems are rangefrom bi- andtri-block copolymers to DNA structures as well as simple and complex proteins andpeptides. The ultimate goal is to harness molecular self-assembly such that design andcontrol ofbottom-up processes is achieved thereby enabling exploitation of structures developed at the meso- and macro-scopic scale for the purposes oflife and non-life science applications. Such aspirations can be achievedthrough understanding thefundamental principles behind the selforganisation and self-synthesis processes exhibited by biological systems.

Directive Effect of Chain Length in Modulating Peptide Nano-assemblies

2020 ◽  
Vol 27 (9) ◽  
pp. 923-929
Author(s):  
Gaurav Pandey ◽  
Prem Prakash Das ◽  
Vibin Ramakrishnan
Keyword(s):  
Electron Microscopy ◽  
Amino Acids ◽  
Light Scattering ◽  
Chain Length ◽  
Self Assembly ◽  
The Self ◽  
Ionic Charge ◽  
Self Assembling ◽  
Biophysical Techniques

Background: RADA-4 (Ac-RADARADARADARADA-NH2) is the most extensively studied and marketed self-assembling peptide, forming hydrogel, used to create defined threedimensional microenvironments for cell culture applications. Objectives: In this work, we use various biophysical techniques to investigate the length dependency of RADA aggregation and assembly. Methods: We synthesized a series of RADA-N peptides, N ranging from 1 to 4, resulting in four peptides having 4, 8, 12, and 16 amino acids in their sequence. Through a combination of various biophysical methods including thioflavin T fluorescence assay, static right angle light scattering assay, Dynamic Light Scattering (DLS), electron microscopy, CD, and IR spectroscopy, we have examined the role of chain-length on the self-assembly of RADA peptide. Results: Our observations show that the aggregation of ionic, charge-complementary RADA motifcontaining peptides is length-dependent, with N less than 3 are not forming spontaneous selfassemblies. Conclusion: The six biophysical experiments discussed in this paper validate the significance of chain-length on the epitaxial growth of RADA peptide self-assembly.

Self-assembling behaviour of a modified aromatic amino acid in competitive medium

Soft Matter ◽  
2020 ◽  
Vol 16 (28) ◽  
pp. 6599-6607 ◽  
Author(s):  
Pijush Singh ◽  
Souvik Misra ◽  
Nayim Sepay ◽  
Sanjoy Mondal ◽  
Debes Ray ◽  
...  
Keyword(s):  
Amino Acid ◽  
Self Assembly ◽  
Aromatic Amino Acid ◽  
Photophysical Properties ◽  
Solvent Mixture ◽  
The Self ◽  
Solvent Ratio ◽  
Self Assembling

The self-assembly and photophysical properties of 4-nitrophenylalanine (4NP) are changed with the alteration of solvent and final self-assembly state of 4NP in competitive solvent mixture and are dictated by the solvent ratio.

Sign in / Sign up

Export Citation Format

Share Document