Resettable and enzyme-free molecular logic devices for the intelligent amplification detection of multiple miRNAs via catalyzed hairpin assembly

Nanoscale ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 5048-5057 ◽  
Author(s):  
Siqi Zhang ◽  
Kai-Bin Li ◽  
Wei Shi ◽  
Jie Zhang ◽  
De-Man Han ◽  
...  
Keyword(s):  
Detection System ◽  
Logic Gates ◽  
Magnetic Bead ◽  
Multiplex Detection ◽  
Logic Function ◽  
Logic Devices ◽  
Molecular Logic ◽  
Catalyzed Hairpin Assembly

In this work, we developed a magnetic bead/DNA system to construct a library of logic gates, enabling the sensing of multiplex target miRNAs. The CHA-based multiplex detection system can distinguish individual target miRNAs under a logic function control.

Design of multifunctional spin logic gates based on manganese porphyrin molecules connected to graphene electrodes

2021 ◽  
Author(s):  
Wenfei Zhang ◽  
Guang-Ping Zhang ◽  
Zong-Liang Li ◽  
Xiaoxiao Fu ◽  
Chuankui Wang ◽  
...  
Keyword(s):  
Transport Properties ◽  
Green's Function ◽  
Logic Gates ◽  
Atomic Chain ◽  
Manganese Porphyrin ◽  
Logic Devices ◽  
Molecular Logic ◽  
Spin Logic ◽  
Non Equilibrium Green’S Function ◽  
Non Equilibrium

The spin-resolved transport properties of molecular logic devices composed of two Mn porphyrin molecules connected to each other via a six-carbon atomic chain were studied using the non-equilibrium Green’s function...

scholarly journals Exploring the design space of recombinase logic circuits.

2019 ◽  
Author(s):  
Sarah Guiziou ◽  
Guillaume Perution-Kihli ◽  
Federico Ulliana ◽  
Michel Leclere ◽  
Jerome Bonnet
Keyword(s):  
Design Space ◽  
Scale Up ◽  
Single Layer ◽  
Logic Gates ◽  
Regulatory Elements ◽  
Logic Circuits ◽  
Logic Function ◽  
Dna Inversion ◽  
Logic Devices ◽  
Logic Functions

Logic circuits operating in living cells are generally built by mimicking electronic layouts, and scale-up is accomplished using additional layers of elementary logic gates like NOT and NOR gates. Recombinase-based logic, in which logic is implemented using DNA inversion or excision, allows for highly efficient, compact and single-layer design architectures. However, recombinase logic architectures depart from electronic design principles, and gate design performed empirically is challenging for an increasing number of inputs. Here we used a combinatorial approach to explore the design space of recombinase logic devices. We generated combinations and permutations of recombination sites, genes, and regulatory elements, for a total of ~19 million designs supporting the implementation of all 2- and 3-input logic functions and up to 92% of 4-input logic functions. We estimated the influence of different design constraints on the number of executable functions, and found that the use of DNA inversion and transcriptional terminators were key factors to implement the vast majority of logic functions. We provide a user-friendly interface, called RECOMBINATOR (http://recombinator.lirmm.fr/index.php), that enable users to navigate the design space of recombinase-based logic, find architectures implementing a specific logic function and sort them according to various biological criteria. Finally, we define a set of 16 architectures from which all 256 3-input logic functions can be derived. This work provides a theoretical foundation for the systematic exploration and design of single-layer recombinase logic devices.

Reversible multi-control fluorescent switch and molecular logic gate based on selective recognition of Fe3+ and its application to multiplex detection

2014 ◽  
Vol 6 (22) ◽  
pp. 9015-9021 ◽  
Author(s):  
Yan Liang ◽  
Weizhou Liu ◽  
Hui Zhang ◽  
Fang Chen
Keyword(s):  
Logic Gate ◽  
Logic Gates ◽  
Selective Recognition ◽  
Schematic Diagram ◽  
Binding Modes ◽  
Multiplex Detection ◽  
Working Process ◽  
Molecular Logic Gate ◽  
Molecular Logic ◽  
Molecular Logic Gates

Schematic diagram describing the working process of molecular logic gates (a) “NOR”, (b) “OR”, and (c) “INHIBIT”, and (d) the possible binding modes between PA and Fe3+.

Fluorescent Molecular Logic Gates Driven by Temperature and by Protons in Solution and on Solid

2021 ◽  
Author(s):  
Amilra Prasanna de Silva ◽  
Matthew West ◽  
Chao-Yi Yao ◽  
Gavin Melaugh ◽  
Kyoko Kawamoto ◽  
...  
Keyword(s):  
Logic Gates ◽  
Molecular Logic ◽  
Molecular Logic Gates

Synthesis and spectral investigation of colorimetric receptors for the dual detection of copper and acetate ions: application in molecular logic gates

2017 ◽  
Vol 29 (8) ◽  
pp. 561-574 ◽  
Author(s):  
Srikala Pangannaya ◽  
Arshiya Kaur ◽  
Makesh Mohan ◽  
Keyur Raval ◽  
Dillip Kumar Chand ◽  
...  
Keyword(s):  
Logic Gates ◽  
Spectral Investigation ◽  
Molecular Logic ◽  
Molecular Logic Gates ◽  
Dual Detection

Design of fully photonic molecular logic gates based on the supramolecular bis-styrylquinoline dyad

2012 ◽  
Vol 7 (5-6) ◽  
pp. 280-287 ◽  
Author(s):  
M. F. Budyka ◽  
N. I. Potashova ◽  
T. N. Gavrishova ◽  
V. M. Li
Keyword(s):  
Logic Gates ◽  
Molecular Logic ◽  
Molecular Logic Gates

Recent advances in molecular logic gate chemosensors based on luminescent metal organic frameworks

2021 ◽  
Author(s):  
Bei Li ◽  
Dongsheng Zhao ◽  
Feng Wang ◽  
Xiaoxian Zhang ◽  
Wenqian Li ◽  
...  
Keyword(s):  
Logic Gate ◽  
Metal Organic Frameworks ◽  
Logic Gates ◽  
Design Strategies ◽  
Molecular Logic Gate ◽  
Future Developments ◽  
Molecular Logic ◽  
Molecular Logic Gates ◽  
Recent Advances ◽  
Metal Organic

This review covers the latest advancements of molecular logic gates based on LMOF. The classification, design strategies, related sensing mechanisms, future developments, and challenges of LMOFs-based logic gates are discussed.

Binaphthyl-derived salicylidene Schiff base for dual-channel sensing of Cu, Zn cations and integrated molecular logic gates

2010 ◽  
Vol 145 (2) ◽  
pp. 826-831 ◽  
Author(s):  
Shichao Wang ◽  
Guangwen Men ◽  
Liyan Zhao ◽  
Qiufei Hou ◽  
Shimei Jiang
Keyword(s):  
Schiff Base ◽  
Logic Gates ◽  
Dual Channel ◽  
Molecular Logic ◽  
Molecular Logic Gates ◽  
Channel Sensing
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