Multifunctional Zn doped hollow mesoporous silica/polycaprolactone electrospun membranes with enhanced hair follicle regeneration and antibacterial activity for wound healing

Nanoscale ◽  
2019 ◽  
Vol 11 (13) ◽  
pp. 6315-6333 ◽  
Author(s):  
Yu Zhang ◽  
Mengling Chang ◽  
Feng Bao ◽  
Min Xing ◽  
Endian Wang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Antibacterial Activity ◽  
Cell Migration ◽  
Mesoporous Silica ◽  
Hair Follicle ◽  
Antibacterial Effect ◽  
Stimulate Cell ◽  
Electrospun Membranes ◽  
Hollow Mesoporous Silica

Hollow CiH-HMZS nanospheres exert a synergistic antibacterial effect, stimulate cell migration and angiogenesis, and enhance hair follicle regeneration.

scholarly journals Lactic-co-glycolic acid-coated methylene blue nanoparticles with enhanced antibacterial activity for efficient wound healing

RSC Advances ◽  
2020 ◽  
Vol 10 (21) ◽  
pp. 12304-12307
Author(s):  
Xiaomu Xu ◽  
Yusheng Hu ◽  
Li-peng Zhang ◽  
Bo Liu ◽  
Yue Yang ◽  
...  
Keyword(s):  
Methylene Blue ◽  
Wound Healing ◽  
Antibacterial Activity ◽  
Singlet Oxygen ◽  
Glycolic Acid ◽  
Antibacterial Effect ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation

Enhanced antibacterial effect of MPNPs through increased singlet oxygen generation as a result of decreased ACQ effect

Exploration of Antibacterial and Wound Healing Potential of PLGA/silk fibroin Based Electrospun Membrane Loaded with Zinc oxide Nanoparticles

2021 ◽  
Author(s):  
Atta ur Rehman Khan ◽  
Kai Huang ◽  
Jinzhong Zhao ◽  
Tonghe Zhu ◽  
Yos Morsi ◽  
...  
Keyword(s):  
Wound Healing ◽  
Zinc Oxide ◽  
Cell Migration ◽  
Silk Fibroin ◽  
Zinc Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Electrospun Membrane ◽  
Stimulate Cell ◽  
Anti Inflammatory

Zinc oxide nanoparticles (ZnO NP) are known for their antibacterial, antioxidant, and anti-inflammatory activities. Moreover, ZnO NP can stimulate cell migration, re-epithelialization, and angiogenesis. All these attributes are highly relevant...

A Photoactivable Formaldehyde Donor with Fluorescence Monitoring Reveals Threshold to Arrest Cell Migration

2019 ◽  
Author(s):  
Lukas P Smaga ◽  
Nicholas W Pino ◽  
Gabriela E Ibarra ◽  
Vishnu Krishnamurthy ◽  
Jefferson Chan
Keyword(s):  
Wound Healing ◽  
Cell Migration ◽  
Fluorescence Enhancement ◽  
Biological Effects ◽  
Cellular Systems ◽  
Live Cells ◽  
First Report ◽  
Cell Lysate ◽  
Intracellular Release ◽  
Biological Analytes

Controlled light-mediated delivery of biological analytes enables the investigation of highly reactivity molecules within cellular systems. As many biological effects are concentration dependent, it is critical to determine the location, time, and quantity of analyte donation. In this work, we have developed the first photoactivatable donor for formaldehyde (FA). Our optimized photoactivatable donor, photoFAD-3, is equipped with a fluorescence readout that enables monitoring of FA release with a concomitant 139-fold fluorescence enhancement. Tuning of photostability and cellular retention enabled quantification of intracellular FA release through cell lysate calibration. Application of photoFAD-3 uncovered the concentration range necessary for arresting wound healing in live cells. This marks the first report where a photoactivatable donor for any analyte has been used to quantify intracellular release.

APPLICATIONS OF CHITOSAN-SULFATHIAZOLE AS ANTIMICROBIAL AGENT

2018 ◽  
Vol 28 (2) ◽  
pp. 429-432
Author(s):  
Dilyana Zvezdova
Keyword(s):  
Wound Healing ◽  
Antibacterial Activity ◽  
Fourier Transform ◽  
Infrared Spectroscopy ◽  
Antimicrobial Agent ◽  
Defense Mechanisms ◽  
Solvent Casting ◽  
Casting Method ◽  
Gram Negative ◽  
Positively Charged

Chitosan, a hydrophilic biopolymer industrially obtained by N-deacetylation of chitin, can be applied as an antimicrobial agent. It highlights the applications of chitosan as an antimicrobial agent against fungi, bacteria, and viruses and as an elicitor of plant defense mechanisms. A series of novel chitosan-sulfathiazole nanocomposite (CSFZ) films were prepared by using solvent casting method for wound healing application. Fourier transform infrared spectroscopy (FTIR) was employed to ascertain the interaction between negatively charged sulfathiazole and positively charged chitosan. Moreover, the antibacterial activity of the films was investigated against gram positive and gram negative microorganisms. It was found that all CSFZ films showed good inhibitory activity against all the tested bacteria as compared to control. The above analysis suggested that the CSFZ films could be used as potential candidates for wound healing application.

Antibacterial Activity of Biodegradable Particles based on Chitosan Containing Colloidal Silver

2020 ◽  
Vol 36 (4) ◽  
pp. 87-93
Author(s):  
V.Yu. Reshetova ◽  
A.F. Krivoshchepov ◽  
I.A. Butorova ◽  
N.B. Feldman ◽  
S.V. Lutsenko ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Antibacterial Activity ◽  
Polymer Matrix ◽  
Adipic Acid ◽  
Antibacterial Effect ◽  
Academic Excellence ◽  
Colloidal Silver ◽  
Scanning Electron Microscopy Data ◽  
Covalent Bonds ◽  
Agar Diffusion Test

Chitosan beads with colloidal silver nanoparticles inclued in the polymer matrix have been obtained by the introduction of chitosan into an acidified nanosilver sol. Dual interconnection of drops of the resulting solution was then carried out by ionotropic gelation at the first stage and covalent crosslinking of the polymer matrix with adipic acid at the second stage. The surface morphology of the obtained beads was studied by scanning electron microscopy. Data of Fourier transform IR spectroscopy confirmed the formation of covalent bonds between chitosan and adipic acid. The antibacterial activity of obtained beads against S. aureus and E. coli was evaluated using agar diffusion test. It was shown that the сhitosan beads modified with nanostructured silver exhibited an antibacterial effect against the tested strains, and they can be used as a basis for creating biodegradable wound healing dressings with a prolonged antibacterial effect. chitosan, silver nanoparticles, antibacterial activity, wound dressings This work was supported by the "Russian Academic Excellence Project 5-100". The study was carried out with the financial support of the Russian Foundation for Basic Research in the framework of the Scientific Project no. 18-29-18039.

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