Microfluidic manufacturing of surface-functionalized graphene oxide nanoflakes for gene delivery

Nanoscale ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 2733-2741 ◽  
Author(s):  
Riccardo Di Santo ◽  
Luca Digiacomo ◽  
Sara Palchetti ◽  
Valentina Palmieri ◽  
Giordano Perini ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Gene Delivery ◽  
Transfection Efficiency ◽  
Cationic Lipids ◽  
Hybrid Nanoparticles ◽  
Functionalized Graphene ◽  
Functionalized Graphene Oxide ◽  
Microfluidic Assembly

Microfluidic assembly of graphene oxide nanoflakes and cationic lipids produces surface functionalized hybrid nanoparticles with superior transfection efficiency and no cytotoxicity.

Multi-functionalized graphene oxide complex as a plasmid delivery system for targeting hepatocellular carcinoma therapy

RSC Advances ◽  
2016 ◽  
Vol 6 (27) ◽  
pp. 22461-22468 ◽  
Author(s):  
Chunyang Wang ◽  
Xiaoqin Wang ◽  
Tong Lu ◽  
Fangshi Liu ◽  
Baofeng Guo ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Graphene Oxide ◽  
Gene Delivery ◽  
Transfection Efficiency ◽  
Functionalized Graphene ◽  
Functionalized Graphene Oxide ◽  
Gene Delivery Vector ◽  
Delivery Vector ◽  
Size Stability ◽  
Plasmid Delivery

A novel and efficient graphene-based gene delivery vector was prepared, the effect of changing the PEI content on the size, stability and transfection efficiency were investigated.

Polymer Functionalized Graphene Oxide: A Versatile Nanoplatform for Drug/Gene Delivery

2015 ◽  
Vol 19 (18) ◽  
pp. 1828-1837 ◽  
Author(s):  
George V. Theodosopoulos ◽  
Panayiotis Bilalis ◽  
Georgios Sakellariou
Keyword(s):  
Graphene Oxide ◽  
Gene Delivery ◽  
Functionalized Graphene ◽  
Functionalized Graphene Oxide

Synthesis and characterization of an octaarginine functionalized graphene oxide nano-carrier for gene delivery applications

2015 ◽  
Vol 17 (9) ◽  
pp. 6328-6339 ◽  
Author(s):  
Rana Imani ◽  
Shahriar Hojjati Emami ◽  
Shahab Faghihi
Keyword(s):  
Gene Therapy ◽  
Graphene Oxide ◽  
Gene Delivery ◽  
Gene Carrier ◽  
Synthesis And Characterization ◽  
Functionalized Graphene ◽  
Functionalized Graphene Oxide

The success of gene therapy is largely dependent on the development of a gene carrier.

Chitosan-Functionalized Graphene Oxide as a Nanocarrier for Drug and Gene Delivery

Small ◽  
2011 ◽  
Vol 7 (11) ◽  
pp. 1569-1578 ◽  
Author(s):  
Hongqian Bao ◽  
Yongzheng Pan ◽  
Yuan Ping ◽  
Nanda Gopal Sahoo ◽  
Tongfei Wu ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Gene Delivery ◽  
Functionalized Graphene ◽  
Functionalized Graphene Oxide ◽  
Drug And Gene Delivery

Polyethylenimine-functionalized graphene oxide as an efficient gene delivery vector

2011 ◽  
Vol 21 (21) ◽  
pp. 7736 ◽  
Author(s):  
Biao Chen ◽  
Min Liu ◽  
Liming Zhang ◽  
Jie Huang ◽  
Jianlin Yao ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Gene Delivery ◽  
Functionalized Graphene ◽  
Functionalized Graphene Oxide ◽  
Gene Delivery Vector ◽  
Delivery Vector ◽  
Efficient Gene

Stepwise Development of Biomimetic Chimeric Peptides for Gene Delivery

2020 ◽  
Vol 27 (8) ◽  
pp. 698-710
Author(s):  
Roya Cheraghi ◽  
Mahboobeh Nazari ◽  
Mohsen Alipour ◽  
Saman Hosseinkhani
Keyword(s):  
Gene Delivery ◽  
Targeted Delivery ◽  
Viral Vectors ◽  
Large Scale ◽  
Transfection Efficiency ◽  
Cationic Lipids ◽  
Target Cells ◽  
Scale Production ◽  
Stepwise Development ◽  
Chimeric Peptides

Gene-based therapy largely relies on the vector type that allows a selective and efficient transfection into the target cells with maximum efficacy and minimal toxicity. Although, genes delivered utilizing modified viruses transfect efficiently and precisely, these vectors can cause severe immunological responses and are potentially carcinogenic. A promising method of overcoming this limitation is the use of non-viral vectors, including cationic lipids, polymers, dendrimers, and peptides, which offer potential routes for compacting DNA for targeted delivery. Although non-viral vectors exhibit reduced transfection efficiency compared to their viral counterpart, their superior biocompatibility, non-immunogenicity and potential for large-scale production make them increasingly attractive for modern therapy. There has been a great deal of interest in the development of biomimetic chimeric peptides. Biomimetic chimeric peptides contain different motifs for gene translocation into the nucleus of the desired cells. They have motifs for gene targeting into the desired cell, condense DNA into nanosize particles, translocate the gene into the nucleus and enhance the release of the particle into the cytoplasm. These carriers were developed in recent years. This review highlights the stepwise development of the biomimetic chimeric peptides currently being used in gene delivery.

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