Distribution of superparamagnetic Au/Fe nanoparticles in an isolated guinea pig brain with an intact blood brain barrier

Nanoscale ◽  
2018 ◽  
Vol 10 (47) ◽  
pp. 22420-22428 ◽  
Author(s):  
Barbara Sanavio ◽  
Laura Librizzi ◽  
Paolo Pennacchio ◽  
Galina V. Beznoussenko ◽  
Fernanda Sousa ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Blood Brain Barrier ◽  
Brain Parenchyma ◽  
Brain Barrier ◽  
Blood Brain ◽  
Pig Brain ◽  
Fe Nanoparticles ◽  
The Brain ◽  
Guinea Pig Brain

Superparamagnetic Au/Fe nanoparticles penetrate the brain parenchyma in an isolated guinea pig brain with an intact blood brain barrier.

Transport of 3H L-Alanine Across the Blood-Brain Barrier of in Situ Perfused Guinea Pig Brain

1996 ◽  
pp. 35-39
Author(s):  
Ivanka D. Markovic ◽  
Zoran B. Redzic ◽  
Suzana S. Jovanovic ◽  
Dusan M. Mitrovic ◽  
Ljubisa M. Rakic
Keyword(s):  
Guinea Pig ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Blood Brain ◽  
Pig Brain ◽  
Guinea Pig Brain

Transport of Leucine-Enkephalin Across the Blood-Brain Barrier in the Perfused Guinea Pig Brain

1987 ◽  
Vol 49 (1) ◽  
pp. 310-315 ◽  
Author(s):  
Berislav V. Zloković ◽  
Milo N. Lipovac ◽  
David J. Begley ◽  
Hugh Davson ◽  
Ljubiša Rakić
Keyword(s):  
Guinea Pig ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Leucine Enkephalin ◽  
Blood Brain ◽  
Pig Brain ◽  
Guinea Pig Brain

Slow Penetration of Thyrotropin-Releasing Hormone Across the Blood-Brain Barrier of an In Situ Perfused Guinea Pig Brain

1988 ◽  
Vol 51 (1) ◽  
pp. 252-257 ◽  
Author(s):  
Berislav V. Zloković ◽  
Milo N. Lipovac ◽  
David J. Begley ◽  
Hugh Davson ◽  
Ljubiša Rakić
Keyword(s):  
Guinea Pig ◽  
Blood Brain Barrier ◽  
Thyrotropin Releasing Hormone ◽  
Brain Barrier ◽  
Releasing Hormone ◽  
Blood Brain ◽  
Pig Brain ◽  
Guinea Pig Brain

Saturable mechanism for delta sleep-inducing peptide (DSIP) at the blood-brain barrier of the vascularly perfused guinea pig brain

Peptides ◽  
1989 ◽  
Vol 10 (2) ◽  
pp. 249-254 ◽  
Author(s):  
Berislav V. Zlokovic ◽  
Veselinka T. Susic ◽  
Hugh Davson ◽  
David J. Begley ◽  
Ratko M. Jankov ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Blood Brain ◽  
Pig Brain ◽  
Delta Sleep ◽  
Guinea Pig Brain ◽  
Delta Sleep Inducing Peptide

Blood-brain barrier preservation in the in vitro isolated guinea pig brain preparation

2001 ◽  
Vol 66 (2) ◽  
pp. 289-297 ◽  
Author(s):  
Laura Librizzi ◽  
Damir Janigro ◽  
Silvia De Biasi ◽  
Marco de Curtis
Keyword(s):  
Guinea Pig ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Blood Brain ◽  
Pig Brain ◽  
Guinea Pig Brain

scholarly journals The Potential Roles of Blood–Brain Barrier and Blood–Cerebrospinal Fluid Barrier in Maintaining Brain Manganese Homeostasis

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1833
Author(s):  
Shannon Morgan McCabe ◽  
Ningning Zhao
Keyword(s):  
Cerebrospinal Fluid ◽  
Blood Brain Barrier ◽  
Blood Circulation ◽  
Critical Role ◽  
Systemic Circulation ◽  
Brain Parenchyma ◽  
Brain Barrier ◽  
Blood Brain ◽  
The Brain

Manganese (Mn) is a trace nutrient necessary for life but becomes neurotoxic at high concentrations in the brain. The brain is a “privileged” organ that is separated from systemic blood circulation mainly by two barriers. Endothelial cells within the brain form tight junctions and act as the blood–brain barrier (BBB), which physically separates circulating blood from the brain parenchyma. Between the blood and the cerebrospinal fluid (CSF) is the choroid plexus (CP), which is a tissue that acts as the blood–CSF barrier (BCB). Pharmaceuticals, proteins, and metals in the systemic circulation are unable to reach the brain and spinal cord unless transported through either of the two brain barriers. The BBB and the BCB consist of tightly connected cells that fulfill the critical role of neuroprotection and control the exchange of materials between the brain environment and blood circulation. Many recent publications provide insights into Mn transport in vivo or in cell models. In this review, we will focus on the current research regarding Mn metabolism in the brain and discuss the potential roles of the BBB and BCB in maintaining brain Mn homeostasis.

IMMUNOHISTOCHEMICAL STUDIES OF BLOOD BRAIN BARRIER AFTER ADMINISTRATION OF ABHRAK BHASM IN WISTAR RATS

2021 ◽  
pp. 13-19
Author(s):  
Amita Singh ◽  
Raj Kumar ◽  
S. K. Kannaujia ◽  
Manikrishna Manikrishna ◽  
N. P. Singh
Keyword(s):  
Blood Brain Barrier ◽  
Wistar Rats ◽  
Brain Parenchyma ◽  
Brain Barrier ◽  
Major Constituent ◽  
Control Group ◽  
Blood Brain ◽  
Biological Studies ◽  
Immunohistochemical Studies ◽  
The Brain

Abhrak bhasma (AB) is a type of bhasma prepared from repeated incineration of mineral mica with decoctions of about 72 herbs. The particle size of Abhrak bhasm has been shown to be in the range of 29-88 nanometers and Fe, Ca, Si, Mg and K are found to be as major constituent. Many drugs developed to treat Central Nervous System (CNS) disorders are unable to reach the brain parenchyma in therapeutically relevant concentrations. The blood brain barrier protects brain parenchyma from the uctuation of plasma composition, from pathogenic agents and maintains homeostasis of the brain parenchyma by restricting non-specic ux of ions, peptides, proteins and even cells into and out the brain. Immunohistochemistry is being widely employed as a tool for biological studies. This study is conducted to examine the change in the continuity of Blood brain barrier by using immunohistochemistry, once Abhrak bhasm drug is given in experimental animal and also to examine the histology of organs. In this study a total of 30 adult albino Wistar rats of approximately 4 months age (approx. 150-200 gms) of either sex selected randomly to see the effect of Abhrak bhasm, an ayurvedic drug on Wistar rats. The rats were weighed, marked and divided into 5 groups each consisting of six animals. In normal control group (Group E), no drug was administered and in rest of the four treated groups (Group-A,B,C,D), Abhrak bhasm @ 36 mg/kg B.wt. was administered orally once in each rat. Brain, liver, kidneys,spleen and blood samples were collected in 10% formalin solution after euthanizing the rats at 0.5,2,6 & 12 hours of Abhrak bhasma drug intervention. The alterations in any of the biochemical parameters are within the tolerable limits of liver and kidney since the dose of abhrak bhasm did not affect liver and kidneys. In the present study, the increase in ALP level may be the result of alterations in metabolisms that occurred without any signicant alteration in histology of liver. After applying the immunohistochemistry with the research markers GFAP, CD 34, S 100, GLUT-1 and RECA-1 on the rats in groups A,B,C and D, there was no change in the intensity of immunohistochemistry, with respect to control. While on applying the Occludin, the intensity of immunohistochemistry was reduced in all the treatment groups as compared to the control group. On the basis of ndings of present study it can be concluded that the therapeutic dose of Abhrak bhasma causes changes at the level of tight junctions present in blood brain barrier in rats which is shown by immunohistochemistry with occludin research marker. There is no toxic effect of drug on different organs of rats as no signicant changes in histology of organs are seen. More studies need to be done to check the permeability of blood brain barrier for Abhrak bhasma drug, like calculating its concentration in brain tissues and other vital organs of rat.

Sign in / Sign up

Export Citation Format

Share Document