Natural killer cells’ immune response requires a minimal nanoscale distribution of activating antigens

Nanoscale ◽  
2018 ◽  
Vol 10 (30) ◽  
pp. 14651-14659 ◽  
Author(s):  
Yossi Keydar ◽  
Guillaume Le Saux ◽  
Ashish Pandey ◽  
Edri Avishay ◽  
Netanel Bar-Hanin ◽  
...  
Keyword(s):  
Immune Response ◽  
Natural Killer Cells ◽  
Natural Killer ◽  
Nk Cell ◽  
Spatial Arrangement ◽  
Immune Stimulation ◽  
Killer Cells ◽  
Molecular Scale

Minimal spatial arrangement of activating ligands needed for NK cell immune stimulation was revealed using a molecular-scale nanofabricated biochip.

scholarly journals The Role of Natural Killer Cells in the Immune Response in Kidney Transplantation

2020 ◽  
Vol 11 ◽  
Author(s):  
Paola Pontrelli ◽  
Federica Rascio ◽  
Giuseppe Castellano ◽  
Giuseppe Grandaliano ◽  
Loreto Gesualdo ◽  
...  
Keyword(s):  
Immune Response ◽  
Kidney Transplantation ◽  
Natural Killer Cells ◽  
Natural Killer ◽  
Killer Cells

scholarly journals Selection and expansion of natural killer cells for NK cell-based immunotherapy

2016 ◽  
Vol 65 (4) ◽  
pp. 477-484 ◽  
Author(s):  
Petra S. A. Becker ◽  
Garnet Suck ◽  
Paulina Nowakowska ◽  
Evelyn Ullrich ◽  
Erhard Seifried ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Natural Killer ◽  
Nk Cell ◽  
Killer Cells

scholarly journals Anti-KIR antibody enhancement of anti-lymphoma activity of natural killer cells as monotherapy and in combination with anti-CD20 antibodies

Blood ◽  
2014 ◽  
Vol 123 (5) ◽  
pp. 678-686 ◽  
Author(s):  
Holbrook E. Kohrt ◽  
Ariane Thielens ◽  
Aurelien Marabelle ◽  
Idit Sagiv-Barfi ◽  
Caroline Sola ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Natural Killer ◽  
Mhc Class I ◽  
Nk Cell ◽  
Class I ◽  
Lymphoma Cells ◽  
Killer Cells ◽  
Key Points ◽  
Anti Cd20 ◽  
Cd20 Antibodies

Key Points Blockade of inhibitory KIRs with MHC class I antigens on lymphoma cells by anti-KIR antibodies augments NK-cell spontaneous cytotoxicity. In combination with anti-CD20 mAbs, anti-KIR induces enhanced NK cell–mediated, rituximab-dependent cytotoxicity against lymphoma.

scholarly journals Nonstochastic Coexpression of Activation Receptors on Murine Natural Killer Cells

2000 ◽  
Vol 191 (8) ◽  
pp. 1341-1354 ◽  
Author(s):  
Hamish R.C. Smith ◽  
Hubert H. Chuang ◽  
Lawrence L. Wang ◽  
Margarita Salcedo ◽  
Jonathan W. Heusel ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Nk Cells ◽  
Natural Killer ◽  
Nk Cell ◽  
Inhibitory Receptors ◽  
Antigen Receptors ◽  
Killer Cells ◽  
Histocompatibility Complex ◽  
Nk Cell Cytotoxicity

Murine natural killer cells (NK) express lectin-like activation and inhibitory receptors, including the CD94/NKG2 family of receptors that bind Qa-1, and the Ly-49 family that recognizes major histocompatibility complex class I molecules. Here, we demonstrate that cross-linking of NK cells with a new specific anti–Ly-49H mAb induced NK cell cytotoxicity and cytokine production. Ly-49H is expressed on a subset of NK cells and can be coexpressed with Ly-49 inhibitory receptors. However, unlike Ly-49 inhibitory receptors, Ly-49H is not detectable on naive splenic CD3+ T cells, indicating that Ly-49H may be an NK cell–specific activation receptor. In further contrast to the stochastically expressed Ly-49 inhibitory receptors, Ly-49H is preferentially expressed with the Ly-49D activation receptor, and expression of both Ly-49H and Ly-49D is augmented on NK cells that lack receptors for Qa-1 tetramers. On developing splenic NK1.1+ cells, Ly-49D and Ly-49H are expressed later than the inhibitory receptors. These results directly demonstrate that Ly-49H activates primary NK cells, and suggest that expression of Ly-49 activation receptors by NK cells may be specifically regulated on NK cell subsets. The simultaneous expression of multiple activation receptors by individual NK cells contrasts with that of T cell antigen receptors and is relevant to the role of NK cells in innate immunity.

scholarly journals Fewer circulating natural killer cells 28 days after double cord blood transplantation predicts inferior survival and IL-15 response

2016 ◽  
Vol 1 (3) ◽  
pp. 208-218 ◽  
Author(s):  
Rachel J. Bergerson ◽  
Robin Williams ◽  
Hongbo Wang ◽  
Ryan Shanley ◽  
Gretchen Colbenson ◽  
...  
Keyword(s):  
Natural Killer Cells ◽  
Cord Blood ◽  
Nk Cells ◽  
Natural Killer ◽  
Nk Cell ◽  
Cord Blood Transplantation ◽  
Killer Cells ◽  
Cell Numbers ◽  
Blood Transplantation ◽  
Key Points

Key Points Low numbers of reconstituting NK cells at D+28 after dUCBT are associated with inferior DFS. Patients with low NK cell numbers at D+28 have reduced phosphorylation of STAT5 upon IL-15 stimulation and less Eomes expression.

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