Noninvasive real-time monitoring of local drug release using nano-Au-absorbed self-decomposable SiO2 carriers

Nanoscale ◽  
2018 ◽  
Vol 10 (32) ◽  
pp. 15332-15338 ◽  
Author(s):  
Li Fan ◽  
Jingnan Yang ◽  
Ken Cham-Fai Leung ◽  
Chaojun Song ◽  
Quan Li
Keyword(s):  
Drug Release ◽  
Real Time ◽  
Xenograft Model ◽  
Model System ◽  
Imaging Agent ◽  
Tumor Site ◽  
Real Time Monitoring ◽  
Quantitative Correlation ◽  
First Time

In the present work, we demonstrated for the first time in a mice bearing Colo-205 xenograft model system that local drug release at the tumor site can be tracked in real time via the establishment of a quantitative correlation between the drug release and a specific imaging agent for CT.

scholarly journals Non-invasive, real-time reporting drug release in vitro and in vivo

2015 ◽  
Vol 51 (32) ◽  
pp. 6948-6951 ◽  
Author(s):  
Yanfeng Zhang ◽  
Qian Yin ◽  
Jonathan Yen ◽  
Joanne Li ◽  
Hanze Ying ◽  
...  
Keyword(s):  
Drug Release ◽  
Real Time ◽  
Near Infrared ◽  
Reporting System ◽  
Real Time Monitoring ◽  
Near Infrared Fluorescence ◽  
Non Invasive ◽  
Fluorescence Dye

Anin vitroandin vivodrug-reporting system is developed for real-time monitoring of drug release via the analysis of the concurrently released near-infrared fluorescence dye.

scholarly journals NIR-Responsive Lysosomotropic Phototrigger: ʽAIE + ESIPTʼ Active Naphthalene Based Single Component Photoresponsive Nanocarrier with Two-Photon Uncaging and Real-Time Monitoring Ability

2021 ◽  
Author(s):  
Biswajit Roy ◽  
Rakesh Mengji ◽  
Samrat Roy ◽  
Bipul Pal ◽  
Avijit Jana ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Real Time ◽  
Near Infrared ◽  
Single Component ◽  
Photon Absorption ◽  
Real Time Monitoring ◽  
Two Photon ◽  
Nir Light

In recent times, organelle-targeted drug delivery systems gained tremendous attention due to the site specific delivery of active drug molecules resulting in enhanced bioefficacy. In this context, the phototriggered drug delivery system (DDS) for releasing an active molecule is superior as it provides spatial and temporal control over the release. So far, near infrared (NIR) light responsive organelle targeted DDS has not yet been developed. Hence, we introduced a two-photon NIR-light responsive lysosome targeted ʽAIE + ESIPTʼ active single component DDS based on naphthalene chromophore. The Two-photon absorption cross-section of our DDS is 142 GM at 850 nm. The DDS was converted into pure organic nanoparticles for biological applications. Our nano-DDS is capable of selective targeting, AIE-luminogenic imaging, and drug release within the lysosome. In vitro studies using cancerous cell lines showed that our single component photoresponsive nanocarrier exhibited enhanced cytotoxicity and real-time monitoring ability of the drug release.

Multimodal Cancer Treatment: Real Time Monitoring, Optimization, and Synergistic Effects

2008 ◽  
Vol 7 (5) ◽  
pp. 409-414 ◽  
Author(s):  
Gunnar Myhr
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Adjuvant Therapy ◽  
Ionizing Radiation ◽  
Cancer Treatment ◽  
Real Time ◽  
Treatment System ◽  
Multi Drug Resistance ◽  
Real Time Monitoring ◽  
Site Specific

The primary objective of this analysis is to provide the theoretical framework for a novel multimodal cancer treatment system emphasizing the use of ultrasound as a synergistic drug release mechanism, real time monitoring by MRI of hyperthermic, pO2, and ultrasound induced released effects. The aim is to provide a cure for the 20% of cancer victims who will die of complications from local solid tumors. Adjuvant therapy usually refers to surgery preceding or following chemotherapy and/or ionizing radiation treatment to decrease the risk of recurrence, but the absolute benefit for survival obtained with adjuvant therapy compared to control is only approximately 6%. Tumor hypoxia represents a primary therapeutic concern, besides multi-drug resistance (MDR), because it can reduce the effectiveness of drugs and radiotherapy; well-oxygenated cells require one-third the dose of hypoxic cells to achieve a given level of cell killing. The era of systemic and indiscriminate chemotherapeutic drug delivery into both healthy and pathologic tissues is near an end. Targeted drug delivery using nanoparticles is emerging as the new vehicle, either as a single treatment option, as part of adjuvant procedures or as a component of a multimodal cancer treatment system. There are more than 100 nanosized liposomes or particles, and conjugated anticancer agents in various stages of preclinical and clinical development. Active targeting can be achieved by site-specific delivery or site-specific triggering. Ultrasound can be utilized as both a site triggering and synergistic mechanism in drug release. The process can be monitored using MRI by a physical process called cavitation. An analysis of low frequency ultrasound exposure in combination with liposomally encapsulated doxorubicin (Caelyx) on Balb/c nude mice inoculated with a WiDr (human colon cancer) tumor cell line provided tumor growth inhibition of 30–40%. Mild hyperthermia causes mean intratumor pO2 to increase by 25% and enhances tumor radiosensitization. Hyperthermia causes the extravasation of liposome nanoparticles in deep tumor regions. Ionizing radiation improves the distribution and uptake of drugs. Liposomally encapsulated drugs and ultrasound mediated hyperthermia have been proven to circumvent MDR effects. Hyperthermic effects and pO2 monitoring of bodily fluid have been performed by MRI. It is hypothesized that increased vascularization and subsequent increase in pO2 levels to hypoxic regions, and monitoring of drug release through cavitation, can facilitate optimized real time concomitant or sequential treatments of drug therapy, hyperthermia, ionizing radiation, etc., before or after surgery. An improved therapeutic index with the use of the outlined system seems probable.

Definition of a cavitation index for real time monitoring during in vitro liposomal drug release.

2008 ◽  
Vol 124 (4) ◽  
pp. 2485-2485
Author(s):  
Lucie Somaglino ◽  
Guillaume Bouchoux ◽  
Jean‐Louis Mestas ◽  
Adrien Matias ◽  
Jean‐Yves Chapelon ◽  
...  
Keyword(s):  
Drug Release ◽  
Real Time ◽  
Real Time Monitoring ◽  
Liposomal Drug ◽  
Definition Of

scholarly journals Real-Time Monitoring of Anticancer Drug Release with Highly Fluorescent Star-Conjugated Copolymer as a Drug Carrier

2014 ◽  
Vol 15 (4) ◽  
pp. 1355-1364 ◽  
Author(s):  
Feng Qiu ◽  
Dali Wang ◽  
Qi Zhu ◽  
Lijuan Zhu ◽  
Gangsheng Tong ◽  
...  
Keyword(s):  
Drug Release ◽  
Real Time ◽  
Anticancer Drug ◽  
Drug Carrier ◽  
Real Time Monitoring ◽  
Conjugated Copolymer

Ratiometric real-time monitoring of hydroxyapatite–doxorubicin nanotheranostic agents for on-demand tumor targeted chemotherapy

2018 ◽  
Vol 2 (10) ◽  
pp. 1791-1798 ◽  
Author(s):  
Yao Kang ◽  
Wen Sun ◽  
Jiangli Fan ◽  
Zimu Wei ◽  
Suzhen Wang ◽  
...  
Keyword(s):  
Drug Release ◽  
Real Time ◽  
Targeted Chemotherapy ◽  
Real Time Monitoring ◽  
On Demand ◽  
Real Time Tracking

Hydroxyapatite–doxorubicin nanotheranostic agents are used for tumor-targeted chemotherapy, providing a platform for ratiometric real-time tracking of drug release.

Real-time monitoring of anticancer drug release in vitro and in vivo on titania nanoparticles triggered by external glutathione

Talanta ◽  
2012 ◽  
Vol 88 ◽  
pp. 631-637 ◽  
Author(s):  
Mira Kim ◽  
Ji Hye Seo ◽  
Won Il Jeon ◽  
Mi-Yeon Kim ◽  
Keunchang Cho ◽  
...  
Keyword(s):  
Drug Release ◽  
Real Time ◽  
Anticancer Drug ◽  
Titania Nanoparticles ◽  
Real Time Monitoring ◽  
Release In Vitro
Sign in / Sign up

Export Citation Format

Share Document