scholarly journals PEG-copolymer-coated iron oxide nanoparticles that avoid the reticuloendothelial system and act as kidney MRI contrast agents

Nanoscale ◽  
2018 ◽  
Vol 10 (29) ◽  
pp. 14153-14164 ◽  
Author(s):  
Vanessa Gómez-Vallejo ◽  
María Puigivila ◽  
Sandra Plaza-García ◽  
Boguslaw Szczupak ◽  
Rafael Piñol ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Contrast Agents ◽  
Iron Oxide Nanoparticles ◽  
Reticuloendothelial System ◽  
Mri Contrast Agents ◽  
Oxide Nanoparticles ◽  
Mri Contrast ◽  
Gamma Counting ◽  
Magnetic Nanocarriers

PEG coated magnetic nanocarriers avoid the reticuloendothelial system, and show an MRI contrast in the kidneys. The results are supported by SPECT, gamma-counting, MRI and TEM histology.

Synthesis of Iron Oxide Nanoparticles Used as MRI Contrast Agents: A Parametric Study

1999 ◽  
Vol 212 (2) ◽  
pp. 474-482 ◽  
Author(s):  
Lucia Babes ◽  
Benoı̂t Denizot ◽  
Gisèle Tanguy ◽  
Jean Jacques Le Jeune ◽  
Pierre Jallet
Keyword(s):  
Iron Oxide ◽  
Contrast Agents ◽  
Iron Oxide Nanoparticles ◽  
Parametric Study ◽  
Mri Contrast Agents ◽  
Oxide Nanoparticles ◽  
Mri Contrast

scholarly journals Iron oxide nanoparticles stabilized with dendritic polyglycerols as selective MRI contrast agents

Nanoscale ◽  
2014 ◽  
Vol 6 (16) ◽  
pp. 9646-9654 ◽  
Author(s):  
Daniel Nordmeyer ◽  
Patrick Stumpf ◽  
Dominic Gröger ◽  
Andreas Hofmann ◽  
Sven Enders ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Iron Oxide ◽  
Contrast Agent ◽  
Contrast Agents ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Mri Contrast Agents ◽  
Mri Contrast Agent ◽  
Oxide Nanoparticles ◽  
Mri Contrast

Superparamagnetic iron oxide nanoparticles with a dendritic polyglycerol (dPG) sulfate strongly bind to L- and P-selectin. Shielding of leukocytes reduces cell extravasation and binding to endothelial cells indicate inflammation specificity and thus, applicability as selective MRI contrast agent.

scholarly journals Effects of Iron Oxide Nanoparticles as T2-MRI Contrast Agents on Reproductive System in Male Mice

2021 ◽  
Author(s):  
Heyu Yang ◽  
Hui Wang ◽  
Chenghao Wen ◽  
Shun Bai ◽  
Pengfei Wei ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Contrast Agents ◽  
Iron Oxide Nanoparticles ◽  
Reproductive System ◽  
Mri Contrast Agents ◽  
Semen Parameters ◽  
Toxicity Tests ◽  
Oxide Nanoparticles ◽  
Male Mice ◽  
Mri Contrast

Abstract Iron oxide nanoparticles (IONPs)-based contrast agents are widely used for T2-weighted magnetic resonance imaging (MRI) in clinical diagnosis, highlighting the necessity and importance to evaluate their potential systematic toxicities. Although a few previous studies have documented the toxicity concerns of IONPs to major organs, limited data are available on the potential reproductive toxicity caused by IONPs, especially when administrated via intravenous injection to mimic clinical use of MRI contrast agents. Our study aimed to determine whether exposure to IONPs would affect male reproductive system and cause other related health concerns in ICR mice. The mice were intravenously injected with different concentrations IONPs once followed by routine toxicity tests of major organs and a series of reproductive function-related analyses at different time points. As a result, most of the contrast agents were captured by reticuloendothelial system (RES) organs such as liver and spleen, while IONPs have not presented adverse effects on the normal function of these major organs. In contrast, although IONPs were not able to enter testis through the blood testicular barrier (BTB), and they have not impaired the normal testicular structure or altered the serum sex hormones levels, IONPs exposure could damage Sertoli cells in BTB at a relative high concentration. Moreover, IONPs administration led to a short-term reduction in the quantity and quality of sperms in a dose-dependent manner, which might be attributed to the increase of oxidative stress in epididymis. However, the semen parameters have gradually returned to the normal range within 14 days after the initial injection of IONPs. Collectively, these results demonstrated that IONPs could cause reversible damage to the reproductive system of male mice without affecting the main organs, providing new guidance for the clinical application of IONPs as T2-MRI contrast agents.

scholarly journals Exceedingly small iron oxide nanoparticles as positive MRI contrast agents

2017 ◽  
Vol 114 (9) ◽  
pp. 2325-2330 ◽  
Author(s):  
He Wei ◽  
Oliver T. Bruns ◽  
Michael G. Kaul ◽  
Eric C. Hansen ◽  
Mariya Barch ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Mri Contrast Agents ◽  
Oxide Nanoparticles ◽  
Mri Contrast ◽  
Wide Range ◽  
Magnetic Resonance Imaging Mri

Medical imaging is routine in the diagnosis and staging of a wide range of medical conditions. In particular, magnetic resonance imaging (MRI) is critical for visualizing soft tissue and organs, with over 60 million MRI procedures performed each year worldwide. About one-third of these procedures are contrast-enhanced MRI, and gadolinium-based contrast agents (GBCAs) are the mainstream MRI contrast agents used in the clinic. GBCAs have shown efficacy and are safe to use with most patients; however, some GBCAs have a small risk of adverse effects, including nephrogenic systemic fibrosis (NSF), the untreatable condition recently linked to gadolinium (Gd) exposure during MRI with contrast. In addition, Gd deposition in the human brain has been reported following contrast, and this is now under investigation by the US Food and Drug Administration (FDA). To address a perceived need for a Gd-free contrast agent with pharmacokinetic and imaging properties comparable to GBCAs, we have designed and developed zwitterion-coated exceedingly small superparamagnetic iron oxide nanoparticles (ZES-SPIONs) consisting of ∼3-nm inorganic cores and ∼1-nm ultrathin hydrophilic shell. These ZES-SPIONs are free of Gd and show a high T1 contrast power. We demonstrate the potential of ZES-SPIONs in preclinical MRI and magnetic resonance angiography.

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