A redox cycling-amplified electrochemical immunosensor for α-fetoprotein sensitive detection via polydopamine nanolabels

Nanoscale ◽  
2018 ◽  
Vol 10 (28) ◽  
pp. 13572-13580 ◽  
Author(s):  
Haipeng Xiang ◽  
Yunli Wang ◽  
Ming Wang ◽  
Yiran Shao ◽  
Yajing Jiao ◽  
...  
Keyword(s):  
Redox Cycling ◽  
Electrochemical Immunosensor ◽  
Sensitive Detection ◽  
Electrochemical Immunosensors ◽  
First Time

Utilizing polydopamine nanoparticles as label materials in the construction of electrochemical immunosensors for the first time.

Electrochemical Immunosensors Based on Nanostructured Materials for Sensing of Prostate-Specific Antigen: A Review

2020 ◽  
Vol 28 ◽  
Author(s):  
Hayati Filik ◽  
Asiye Aslıhan Avan ◽  
Mustafa Özyürek
Keyword(s):  
Prostate Specific Antigen ◽  
Nanostructured Materials ◽  
Specific Antigen ◽  
Electrochemical Immunosensor ◽  
Label Free ◽  
Electrochemical Immunosensors ◽  
Metal Metal ◽  
Different Types ◽  
Sandwich Type ◽  
Carbon Based Nanomaterials

: The prostate-specific antigen (PSA) has been considered a crucial serological marker for distinguishing prostate based cancer. This surveys recent progress in the construction of nanomaterial-based electrochemical immunosensors for a PSA. This review (from 2015 to 2020) reports the latest progress in PSA sensing based on the employ of different types of nanostructured materials. The most popular used nanostructured materials are metal, metal oxide, carbon-based nanomaterials, and their hybrid architectures utilized for distinct amplification protocols. In this review, the electrochemical immunosensors for prostate-specific antigen sensing are classified into three categories such as sandwich type@labeled, label free@nonlabeled and aptamer-based electrochemical immunosensor.

scholarly journals Metal Nanoparticle and Quantum Dot Tags for Signal Amplification in Electrochemical Immunosensors for Biomarker Detection

Chemosensors ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 85
Author(s):  
Anton Popov ◽  
Benediktas Brasiunas ◽  
Asta Kausaite-Minkstimiene ◽  
Almira Ramanaviciene
Keyword(s):  
Signal Amplification ◽  
Electrochemical Immunosensor ◽  
Metal Nanoparticle ◽  
Biomarker Detection ◽  
Analytical Instruments ◽  
Electrochemical Immunosensors ◽  
Highly Sensitive ◽  
Recent Developments ◽  
Electrochemical Signal ◽  
Detection Of Biomarkers

With the increasing importance of healthcare and clinical diagnosis, as well as the growing demand for highly sensitive analytical instruments, immunosensors have received considerable attention. In this review, electrochemical immunosensor signal amplification strategies using metal nanoparticles (MNPs) and quantum dots (Qdots) as tags are overviewed, focusing on recent developments in the ultrasensitive detection of biomarkers. MNPs and Qdots can be used separately or in combination with other nanostructures, while performing the function of nanocarriers, electroactive labels, or catalysts. Thus, different functions of MNPs and Qdots as well as recent advances in electrochemical signal amplification are discussed. Additionally, the methods most often used for antibody immobilization on nanoparticles, immunoassay formats, and electrochemical methods for indirect biomarker detection are overviewed.

Crystalline quantum dots of covalent organic frameworks for fast and sensitive detection of uranium

2020 ◽  
Vol 56 (6) ◽  
pp. 880-883 ◽  
Author(s):  
Meicheng Zhang ◽  
Yang Li ◽  
Lijian Ma ◽  
Xinghua Guo ◽  
Xiaofeng Li ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Quantum Dot ◽  
Sensitive Detection ◽  
Covalent Organic Frameworks ◽  
First Time

A crystalline quantum dot of a COF was prepared for the first time by original BRB method for fast uranium detection.

scholarly journals Further Advance of Gambierdiscus Species in the Canary Islands, with the First Report of Gambierdiscus belizeanus

Toxins ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 692 ◽  
Author(s):  
Àngels Tudó ◽  
Greta Gaiani ◽  
Maria Rey Varela ◽  
Takeshi Tsumuraya ◽  
Karl B. Andree ◽  
...  
Keyword(s):  
Canary Islands ◽  
Neuroblastoma Cell ◽  
Electrochemical Immunosensor ◽  
Benthic Dinoflagellates ◽  
Food Borne ◽  
Eastern Atlantic Ocean ◽  
North Eastern ◽  
Colorimetric Immunoassay ◽  
Ancient Times ◽  
First Time

Ciguatera Poisoning (CP) is a human food-borne poisoning that has been known since ancient times to be found mainly in tropical and subtropical areas, which occurs when fish or very rarely invertebrates contaminated with ciguatoxins (CTXs) are consumed. The genus of marine benthic dinoflagellates Gambierdiscus produces CTX precursors. The presence of Gambierdiscus species in a region is one indicator of CP risk. The Canary Islands (North Eastern Atlantic Ocean) is an area where CP cases have been reported since 2004. In the present study, samplings for Gambierdiscus cells were conducted in this area during 2016 and 2017. Gambierdiscus cells were isolated and identified as G. australes, G. excentricus, G. caribaeus, and G. belizeanus by molecular analysis. In this study, G. belizeanus is reported for the first time in the Canary Islands. Gambierdiscus isolates were cultured, and the CTX-like toxicity of forty-one strains was evaluated with the neuroblastoma cell-based assay (neuro-2a CBA). G. excentricus exhibited the highest CTX-like toxicity (9.5–2566.7 fg CTX1B equiv. cell−1) followed by G. australes (1.7–452.6.2 fg CTX1B equiv. cell−1). By contrast, the toxicity of G. belizeanus was low (5.6 fg CTX1B equiv. cell−1), and G. caribaeus did not exhibit CTX-like toxicity. In addition, for the G. belizeanus strain, the production of CTXs was evaluated with a colorimetric immunoassay and an electrochemical immunosensor resulting in G. belizeanus producing two types of CTX congeners (CTX1B and CTX3C series congeners) and can contribute to CP in the Canary Islands.

Low fouling and ultrasensitive electrochemical immunosensors with dual assay methods based on Fe3O4 magnetic nanoparticles

2019 ◽  
Vol 7 (38) ◽  
pp. 5842-5847 ◽  
Author(s):  
Wenshi Li ◽  
Gao-Chao Fan ◽  
Xiaojian Fan ◽  
Ruiqiao Zhang ◽  
Lei Wang ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Analytical Methods ◽  
Sensitive Detection ◽  
Fe3o4 Magnetic Nanoparticles ◽  
Cancer Antigen ◽  
Electrochemical Immunosensors ◽  
Highly Sensitive ◽  
Assay Methods ◽  
Highly Sensitive Detection

Low fouling electrochemical immunosensors for the highly sensitive detection of cancer antigen 15-3 with both “signal-off” and “signal-on” analytical methods were developed.

Electrochemical immunosensor based on MoS2 NFs/Au@AgPt YNCs as signal amplification label for sensitive detection of CEA

2019 ◽  
Vol 142 ◽  
pp. 111580 ◽  
Author(s):  
Enhui Ma ◽  
Ping Wang ◽  
Qingshan Yang ◽  
Haoxuan Yu ◽  
Fubin Pei ◽  
...  
Keyword(s):  
Signal Amplification ◽  
Electrochemical Immunosensor ◽  
Sensitive Detection
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