A novel fluorescent adhesive-assisted biomimetic mineralization

Nanoscale ◽  
2018 ◽  
Vol 10 (40) ◽  
pp. 18980-18987 ◽  
Author(s):  
Zhe Wang ◽  
Yan Ouyang ◽  
Zhifang Wu ◽  
Leiqing Zhang ◽  
Changyu Shao ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Polyacrylic Acid ◽  
Amorphous Calcium Phosphate ◽  
Sodium Fluorescein ◽  
Biomimetic Mineralization ◽  
Calcium Phosphate Nanoparticles ◽  
Self Etch

We propose a novel fluorescent adhesive-assisted biomimetic mineralization strategy, based on a mild self-etch adhesive containing 25 wt% polyacrylic acid-stabilized amorphous calcium phosphate nanoparticles and 1 wt% sodium fluorescein.

scholarly journals Fluoride-doped amorphous calcium phosphate nanoparticles as a promising biomimetic material for dental remineralization

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Michele Iafisco ◽  
Lorenzo Degli Esposti ◽  
Gloria Belén Ramírez-Rodríguez ◽  
Francesca Carella ◽  
Jaime Gómez-Morales ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Biomimetic Material ◽  
Calcium Phosphate Nanoparticles

Functionalized Calcium Phosphate-based Nanoparticles for the Treatment of Osteoporosis

2005 ◽  
Vol 873 ◽  
Author(s):  
Balasundaram G ◽  
Sato M ◽  
Webster TJ
Keyword(s):  
Calcium Phosphate ◽  
Bone Formation ◽  
Amorphous Calcium Phosphate ◽  
Bone Growth ◽  
Osteoporotic Bone ◽  
Amino Groups ◽  
Calcium Phosphate Nanoparticles ◽  
Bioactive Agents ◽  
Bone Growth Factor

AbstractIn an effort to decrease the number of problems associated with osteoporosis, the long-term goal of the present study is to design calcium phosphate-based nanoparticles that specifically attach to areas of low bone density and once attached, allow for the targeted release of bioactive agents that can quickly increase bone formation. Efforts are focused on nanoparticles of calcium phosphate-based materials since they are similar in size and chemistry to the major inorganic components of bone. As a first step in this research, the objective of the present study was to synthesize nanoparticles of crystalline hydroxyapatite (or HA) and amorphous calcium phosphate. Crystalline HA is stable under physiological fluids and, thus, will release embedded bioactive agents slowly. Alternatively, amorphous calcium phosphate is highly biodegradable and will, thus, release embedded bioactive agents quickly. A further objective of the present study was to functionalize such inorganic biodegradable materials with amino groups which would allow for the subsequent attachment of entities to direct such nanoparticles to osteoporotic bone and increased bone formation once attached. One promising approach to direct the nanoparticles to osteoporotic bone is to attach antibodies to pentosidine on the nanoparticles since pentosidine is present in higher amounts in osteoporotic compared to healthy bone. A promising approach to increase bone growth once nanoparticles attach to osteoporotic bone, is to embed nanoparticles with regions of the bone growth factor: bone morphogenic protein-2 (or BMP-2). Results of this study demonstrated the successful synthesis of both crystalline HA and amorphous calcium phosphate nanoparticles. Furthermore, results showed that these nanoparticles can be functionalized with versatile amino groups. In this manner, this study takes the first steps toward utilizing calcium phosphate based nanoparticles to reverse bone loss associated with osteoporosis.

scholarly journals Interaction of stable aggregates drives the precipitation of calcium phosphate in supersaturated solutions

CrystEngComm ◽  
2019 ◽  
Vol 21 (42) ◽  
pp. 6354-6364 ◽  
Author(s):  
R. Innocenti Malini ◽  
C. L. Freeman ◽  
J. H. Harding
Keyword(s):  
Molecular Dynamics ◽  
Calcium Phosphate ◽  
Molecular Dynamics Simulations ◽  
Amorphous Calcium Phosphate ◽  
Calcium Phosphate Nanoparticles ◽  
Dynamics Simulations ◽  
First Time ◽  
Supersaturated Solutions

Using molecular dynamics simulations, we show for the first time that calcium phosphate nanoparticles of eight formula units are thermodynamically stable and could be key in the nucleation of amorphous calcium phosphate.

scholarly journals Amorphous calcium phosphate nanoparticles-based mouthwash: preparation, characterization, and anti-bacterial effects

2019 ◽  
Vol 12 (3) ◽  
pp. 278-285 ◽  
Author(s):  
Kimiya Pakravanan ◽  
Mahmood Rezaee Roknabadi ◽  
Fahimeh Farzanegan ◽  
Alireza Hashemzadeh ◽  
Majid Darroudi
Keyword(s):  
Calcium Phosphate ◽  
Amorphous Calcium Phosphate ◽  
Calcium Phosphate Nanoparticles
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