scholarly journals Induction of necrotic cell death and activation of STING in the tumor microenvironment via cationic silica nanoparticles leading to enhanced antitumor immunity

Nanoscale ◽  
2018 ◽  
Vol 10 (19) ◽  
pp. 9311-9319 ◽  
Author(s):  
Myunggi An ◽  
Chunsong Yu ◽  
Jingchao Xi ◽  
Joyce Reyes ◽  
Guangzhao Mao ◽  
...  
Keyword(s):  
Cell Death ◽  
Tumor Microenvironment ◽  
Silica Nanoparticles ◽  
Antitumor Immunity ◽  
Intratumoral Injection ◽  
Necrotic Cell Death ◽  
Necrotic Cell

Potent antitumor immunity is induced by intratumoral injection of cytotoxic silica nanoparticles complexed with a STING agonist.

Cytotoxicity of silica nanoparticles through exocytosis of von Willebrand factor and necrotic cell death in primary human endothelial cells

Biomaterials ◽  
2011 ◽  
Vol 32 (33) ◽  
pp. 8385-8393 ◽  
Author(s):  
Alexander T. Bauer ◽  
Elwira A. Strozyk ◽  
Christian Gorzelanny ◽  
Christoph Westerhausen ◽  
Anna Desch ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Cell Death ◽  
Silica Nanoparticles ◽  
Von Willebrand Factor ◽  
Necrotic Cell Death ◽  
Human Endothelial Cells ◽  
Necrotic Cell ◽  
Von Willebrand ◽  
Willebrand Factor

Oleanolic acid rich solubilized triterpene extracts from mistletoe induce apoptotic and necrotic cell death of murine B16. F10 melanoma cells

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
CM Strüh ◽  
S Jäger ◽  
CM Schempp ◽  
T Jakob ◽  
A Scheffler ◽  
...  
Keyword(s):  
Cell Death ◽  
Oleanolic Acid ◽  
Melanoma Cells ◽  
Necrotic Cell Death ◽  
Necrotic Cell

NADPH Oxidases: New Players in TNF-Induced Necrotic Cell Death

2007 ◽  
Vol 26 (6) ◽  
pp. 769-771 ◽  
Author(s):  
Tom Vanden Berghe ◽  
Wim Declercq ◽  
Peter Vandenabeele
Keyword(s):  
Cell Death ◽  
Necrotic Cell Death ◽  
Necrotic Cell ◽  
Nadph Oxidases

BNip3 is a mediator of TNF-induced necrotic cell death

APOPTOSIS ◽  
2010 ◽  
Vol 16 (2) ◽  
pp. 114-126 ◽  
Author(s):  
Jee-Youn Kim ◽  
Yong-Jun Kim ◽  
Sun Lee ◽  
Jae-Hoon Park
Keyword(s):  
Cell Death ◽  
Necrotic Cell Death ◽  
Necrotic Cell

scholarly journals Protein synthesis persists during necrotic cell death

2005 ◽  
Vol 168 (4) ◽  
pp. 545-551 ◽  
Author(s):  
Xavier Saelens ◽  
Nele Festjens ◽  
Eef Parthoens ◽  
Isabel Vanoverberghe ◽  
Michael Kalai ◽  
...  
Keyword(s):  
Cell Death ◽  
Protein Synthesis ◽  
De Novo ◽  
Translation Initiation Factor ◽  
Initiation Factor ◽  
Necrotic Cell Death ◽  
Necrotic Cell ◽  
Proteolytic Activation ◽  
Double Stranded Rna ◽  
Molecular Events

Cell death is an intrinsic part of metazoan development and mammalian immune regulation. Whereas the molecular events orchestrating apoptosis have been characterized extensively, little is known about the biochemistry of necrotic cell death. Here, we show that, in contrast to apoptosis, the induction of necrosis does not lead to the shut down of protein synthesis. The rapid drop in protein synthesis observed in apoptosis correlates with caspase-dependent breakdown of eukaryotic translation initiation factor (eIF) 4G, activation of the double-stranded RNA-activated protein kinase PKR, and phosphorylation of its substrate eIF2-α. In necrosis induced by tumor necrosis factor, double-stranded RNA, or viral infection, de novo protein synthesis persists and 28S ribosomal RNA fragmentation, eIF2-α phosphorylation, and proteolytic activation of PKR are absent. Collectively, these results show that, in contrast to apoptotic cells, necrotic dying cells retain the opportunity to synthesize proteins.

scholarly journals Pegylated and nanoparticle-conjugated sulfonium salt photo triggers necrotic cell death

2016 ◽  
Vol Volume 11 ◽  
pp. 6161-6168 ◽  
Author(s):  
Alaa A Fadhel ◽  
Xiling Yue ◽  
Ebrahim H Ghazvini Zadeh ◽  
Mykhailo Bondar ◽  
Kevin D Belfield
Keyword(s):  
Cell Death ◽  
Necrotic Cell Death ◽  
Necrotic Cell ◽  
Sulfonium Salt
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