Combining autophagy-inducing peptides and brefeldin A delivered by perinuclear-localized mesoporous silica nanoparticles: a manipulation strategy for ER-phagy

Nanoscale ◽  
2018 ◽  
Vol 10 (18) ◽  
pp. 8796-8805 ◽  
Author(s):  
Yimin Wang ◽  
Zhao Zhao ◽  
Fujing Wei ◽  
Zewei Luo ◽  
Yixiang Duan
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Small Molecule ◽  
Mesoporous Silica Nanoparticles ◽  
Brefeldin A ◽  
Manipulation Strategy ◽  
Perinuclear Area

A small molecule was screened and delivered to the perinuclear area by mesoporous silica nanoparticles for regulating ER-phagy.

Hierarchical integration of degradable mesoporous silica nanoreservoirs and supramolecular dendrimer complex as a general-purpose tumor-targeted biomimetic nanoplatform for gene/small-molecule anticancer drug co-delivery

Nanoscale ◽  
2020 ◽  
Vol 12 (30) ◽  
pp. 16102-16112 ◽  
Author(s):  
Yang Fei ◽  
Menghuan Li ◽  
Yanan Li ◽  
Xuan Wang ◽  
Chencheng Xue ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Anticancer Drugs ◽  
Anticancer Drug ◽  
Small Molecule ◽  
Targeted Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
General Purpose

A biomimetic nanosystem was developed through the hierarchical integration of degradable dendritic mesoporous silica nanoparticles and functional dendrimers for the tumor-targeted delivery of genes and small-molecule anticancer drugs.

Recent Advances in Application of Azobenzenes Grafted on Mesoporous Silica Nanoparticles in Controlled Drug Delivery Systems Using Light as External Stimulus

2020 ◽  
Vol 20 (11) ◽  
pp. 1001-1016
Author(s):  
Sandra Ramírez-Rave ◽  
María Josefa Bernad-Bernad ◽  
Jesús Gracia-Mora ◽  
Anatoly K. Yatsimirsky
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
High Surface ◽  
Delivery Systems ◽  
Surface Reactivity ◽  
External Stimulus ◽  
Recent Advances

Hybrid materials based on Mesoporous Silica Nanoparticles (MSN) have attracted plentiful attention due to the versatility of their chemistry, and the field of Drug Delivery Systems (DDS) is not an exception. MSN present desirable biocompatibility, high surface area values, and a well-studied surface reactivity for tailoring a vast diversity of chemical moieties. Particularly important for DDS applications is the use of external stimuli for drug release. In this context, light is an exceptional alternative due to its high degree of spatiotemporal precision and non-invasive character, and a large number of promising DDS based on photoswitchable properties of azobenzenes have been recently reported. This review covers the recent advances in design of DDS using light as an external stimulus mostly based on literature published within last years with an emphasis on usually overlooked underlying chemistry, photophysical properties, and supramolecular complexation of azobenzenes.

Fluorescent spherical mesoporous silica nanoparticles loaded with emodin: Synthesis, cellular uptake and anticancer activity

2021 ◽  
Vol 119 ◽  
pp. 111619
Author(s):  
Paul Jänicke ◽  
Claudia Lennicke ◽  
Annette Meister ◽  
Barbara Seliger ◽  
Ludger A. Wessjohann ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Anticancer Activity ◽  
Silica Nanoparticles ◽  
Cellular Uptake ◽  
Mesoporous Silica Nanoparticles

Exploiting mesoporous silica nanoparticles as versatile drug carriers for several routes of administration

2021 ◽  
Vol 312 ◽  
pp. 110774
Author(s):  
Rafael Miguel Sábio ◽  
Andréia Bagliotti Meneguin ◽  
Aline Martins dos Santos ◽  
Andreia Sofia Monteiro ◽  
Marlus Chorilli
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Carriers ◽  
Routes Of Administration
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