Mesoporous silica nanoparticles induced hepatotoxicity via NLRP3 inflammasome activation and caspase-1-dependent pyroptosis

Nanoscale ◽  
2018 ◽  
Vol 10 (19) ◽  
pp. 9141-9152 ◽  
Author(s):  
Xuyao Zhang ◽  
Jingyun Luan ◽  
Wei Chen ◽  
Jiajun Fan ◽  
Yanyang Nan ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Nlrp3 Inflammasome ◽  
Mesoporous Silica Nanoparticles ◽  
Silica Nanoparticle ◽  
Underlying Mechanism ◽  
Inflammasome Activation ◽  
Mesoporous Silica Nanoparticle ◽  
Caspase 1 ◽  
Nlrp3 Inflammasome Activation

Novel insights into mesoporous silica nanoparticle (MSN)-induced hepatotoxicity and the underlying mechanism, facilitating an increase of the biosafety of MSNs.

Acid-responsive intracellular doxorubicin release from click chemistry functionalized mesoporous silica nanoparticles

RSC Advances ◽  
2015 ◽  
Vol 5 (39) ◽  
pp. 30640-30646 ◽  
Author(s):  
Yue Yan ◽  
Jie Fu ◽  
Xin Liu ◽  
Tianfu Wang ◽  
Xiuyang Lu
Keyword(s):  
Mesoporous Silica ◽  
Click Chemistry ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Silica Nanoparticle ◽  
Mesoporous Silica Nanoparticle ◽  
Functionalized Mesoporous Silica ◽  
Doxorubicin Release

An intracellular acidity-triggered doxorubicin release from “click chemistry” functionalized mesoporous silica nanoparticle was demonstrated.

scholarly journals Role of ASM/Cer/TXNIP signaling module in the NLRP3 inflammasome activation

2020 ◽  
Author(s):  
Jianjun Jiang ◽  
Jin Yang ◽  
Yining Shi ◽  
Jiyu Cao ◽  
Youjin Lu ◽  
...  
Keyword(s):  
Nlrp3 Inflammasome ◽  
Underlying Mechanism ◽  
Acid Sphingomyelinase ◽  
Receptor Protein ◽  
Inflammasome Activation ◽  
Mrna Levels ◽  
Caspase 1 ◽  
Nlrp3 Inflammasome Activation

Abstract Background: The NOD-Like Receptor Protein 3 (NLRP3) inflammasome is a crucial component of an array of inflammatory conditions. It functions by boosting the secretion of pro-inflammatory cytokines: interleukin-1β (IL-1β) and interleukin-18 (IL-18). Previous studies have established the vital role of the acid sphingomyelinase (ASM)/ceramide (Cer) pathway in the functional outcome of cells, with a particular emphasis on the inflammatory processes. This study aimed to explore the effects and associated underlying mechanism of Cer-induced NLRP3 inflammasome activation.Methods: Lipopolysaccharide (LPS)/adenosine triphosphate (ATP)-induced NLRP3 inflammasome activation in J774A.1 cells was used as an in vitro inflammatory model. Western blotting and Real-time PCR (RT-PCR) were used to detect the protein and mRNA levels, respectively. IL-1β and IL-18 levels were evaluated using ELISA kits. ASM assay kit and immunofluorescence were used to detect ASM activity and Cer content.Results: Imipramine, a well-known inhibitor of ASM, significantly inhibited ASM activity and inhibited Cer accumulation, which indicated ASM activation. Besides, it also suppressed the LPS/ATP-induced expression of proteins and mRNA: thioredoxin interacting protein (TXNIP), NLRP3, caspase-1, IL-1β and IL-18. Interestingly verapamil, a TXNIP inhibitor, suppressed LPS/ATP-induced TXNIP/NLRP3 inflammasome activation; however, it did not affect LPS/ATP-induced ASM activation and ceramide production. Further analysis showed that the exogenous C2-Cer treated J774A.1 cells induced the overexpression of TXNIP, NLRP3, caspase-1, IL-1β and IL-18. Besides, TXNIP siRNA or verapamil inhibited C2-Cer-induced TXNIP overexpression and NLRP3 inflammasome activation.Conclusion: This study demonstrated the involvement of the ASM/Cer/TXNIP signaling pathway in NLRP3 inflammasome activation.

A Review on Application of Multifunctional Mesoporous Nanoparticles in Controlled Release of Drug Delivery

2014 ◽  
Vol 781 ◽  
pp. 17-24 ◽  
Author(s):  
Pragnesh N. Dave ◽  
Lakha V. Chopda
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Silica Nanoparticle ◽  
Disease Diagnosis ◽  
Ammonium Bromide ◽  
Composition Material ◽  
Mesoporous Silica Nanoparticle

In the early 1990s the discovery of the MCM-41 and the M41S family of mesoporous materials had open new era in the chemistry and biology. They have prominent application inbiotechnological, biomedical and heterogeneous catalysts. Mesoporous silica nanoparticles (MSNs) exhibit unique structural features like as their large surface areas, tunable pore sizes in nanometer and well-defined surface properties. MSN materials which are comprised of a honeycomb-like porous structure with hundreds of empty mesoporous channel that are able to encapsulate relatively large amounts of biomolecules. They are ideal candidate for constructing multifunctional materials that encapsulate a variety of functional nanostructured materials. Multifunctional MSN materials have become one of the most attractive areas in nanobiotechnology and nanomedicine for various disease diagnosis and therapy. Multifunctional MSN have been successfully developed as a multifunctional platform to deliver therapeutic and diagnostic agents. Multifunctional MSNs are a highly promising platform for intracellular controlled release of drugs. In this review we discuss the recent developments in design and fabrication of multifunctional mesoporous silica nanoparticles in as efficient drug delivery applications such as the site-specific delivery and intracellular controlled release of drugs.Abbreviations;APTES; 3-aminopropyl triethoxy sialne, ATP; Adenosine triphospahate, CD; cyclodextrinCPT; camptothecin, CS; Chitosan,CTAB; cyltrimethylammonium bromide,DNA; Deoxyribonucleic acid,DOX; doxorubicin,EDC; 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide,FD; fluorescein disodium,FSP;Fluroscent particle ,IBU;ibuprofen,MCM; mobil composition material, MPS; 3-trimethoxylsilyl propyl methacrylate, MS; mesoporous silica,MSN; mesoporous silica nanoparticle, MSNs; mesoporous silica nanoparticles,MSNP; mesoporous silica nanoparticle,NPS; nanoparticles;PFDTES;perfluorodecyltriethoxysilane, PAA; polyacrylic acid,PR;photo responsive,PMAA; polymethyl methacrylate,SBF; simulated body fluid,TEOS;tetraethyl orthosilicate,TUNA;Thio undecyl-tetraethyleneglycoestero-nitrobenzylethyldimethyl ammonium bromide.

Hollow doughnut shaped mesoporous silica nanoparticles for reduction of the thermal expansion coefficient of poly(ether sulfone) films

2018 ◽  
Vol 42 (7) ◽  
pp. 5045-5051
Author(s):  
Nhat Tri Vo ◽  
Astam K. Patra ◽  
Dukjoon Kim
Keyword(s):  
Thermal Stability ◽  
Thermal Expansion ◽  
Optical Properties ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Thermal Expansion Coefficient ◽  
Expansion Coefficient ◽  
Mesoporous Silica Nanoparticles ◽  
Silica Nanoparticle ◽  
Mesoporous Silica Nanoparticle

A hollow doughnut shaped mesoporous silica nanoparticle filler that significantly enhances the dimensional thermal stability without sacrificing the optical properties of poly(ether sulfone) films is reported.

Mesoporous silica nanoparticles with lactose-mediated targeting effect to deliver platinum(iv) prodrug for liver cancer therapy

2017 ◽  
Vol 5 (36) ◽  
pp. 7591-7597 ◽  
Author(s):  
Zigui Wang ◽  
Peng Wu ◽  
Zhilong He ◽  
Hongyan He ◽  
Weifeng Rong ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Liver Cancer ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Silica Nanoparticle ◽  
Mesoporous Silica Nanoparticle ◽  
Nanoparticle System ◽  
Targeting Effect

A mesoporous silica nanoparticle system with a lactose-mediated targeting effect was demonstrated to deliver a platinum(iv) prodrug for liver cancer therapy.

The effect of mesoporous silica nanoparticle surface chemistry and concentration on the α-synuclein fibrillation

RSC Advances ◽  
2015 ◽  
Vol 5 (75) ◽  
pp. 60966-60974 ◽  
Author(s):  
Nayere Taebnia ◽  
Dina Morshedi ◽  
Mohsen Doostkam ◽  
Soheila Yaghmaei ◽  
Farhang Aliakbari ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Surface Chemistry ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Silica Nanoparticle ◽  
Mesoporous Silica Nanoparticle ◽  
Nanoparticle Surface

Surface chemistry/charge and concentration of mesoporous silica nanoparticles have a great impact on the fibrillation process of α-Syn protein.

scholarly journals Curcumin-loaded PEGylated mesoporous silica nanoparticles for effective photodynamic therapy

RSC Advances ◽  
2020 ◽  
Vol 10 (41) ◽  
pp. 24624-24630
Author(s):  
Gaizhen Kuang ◽  
Qingfei Zhang ◽  
Shasha He ◽  
Ying Liu
Keyword(s):  
Photodynamic Therapy ◽  
Mesoporous Silica ◽  
Cancer Treatment ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Silica Nanoparticle ◽  
Mesoporous Silica Nanoparticle ◽  
Nanoparticle System

We developed a Cur loaded PEGylated mesoporous silica nanoparticle system (MSN-PEG@Cur) for effective photodynamic therapy in cancer treatment.

Dual pH-responsive mesoporous silica nanoparticles for efficient combination of chemotherapy and photodynamic therapy

2015 ◽  
Vol 3 (23) ◽  
pp. 4707-4714 ◽  
Author(s):  
Xuemei Yao ◽  
Xiaofei Chen ◽  
Chaoliang He ◽  
Li Chen ◽  
Xuesi Chen
Keyword(s):  
Drug Delivery ◽  
Photodynamic Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Mesoporous Silica Nanoparticles ◽  
Silica Nanoparticle ◽  
Ph Responsive ◽  
Mesoporous Silica Nanoparticle

By metallo-supramolecular coordinated interaction between Zn-Por and histidine, a dual pH-responsive mesoporous silica nanoparticle (MSN)-based drug delivery system has been fabricated for synergistic chemo-photodynamic therapy.

Pore size and concentration effect of mesoporous silica nanoparticles on the coefficient of thermal expansion and optical transparency of poly(ether sulfone) films

2017 ◽  
Vol 19 (3) ◽  
pp. 1937-1944 ◽  
Author(s):  
Nhat Tri Vo ◽  
Astam K. Patra ◽  
Dukjoon Kim
Keyword(s):  
Thermal Stability ◽  
Thermal Expansion ◽  
Optical Properties ◽  
Mesoporous Silica ◽  
Pore Size ◽  
Silica Nanoparticles ◽  
Coefficient Of Thermal Expansion ◽  
Mesoporous Silica Nanoparticles ◽  
Silica Nanoparticle ◽  
Mesoporous Silica Nanoparticle

A mesoporous silica nanoparticle filler that drastically enhances the dimensional thermal stability without sacrificing the optical properties of poly(ether sulfone) films was reported.

Selective neuronal targeting, protection and signaling network analysis via dopamine-mediated mesoporous silica nanoparticles

MedChemComm ◽  
2015 ◽  
Vol 6 (6) ◽  
pp. 1117-1129 ◽  
Author(s):  
Hailong Zhang ◽  
Yuhua Jiang ◽  
Sheng-gang Zhao ◽  
Li-qin Jiang ◽  
Yan Meng ◽  
...  
Keyword(s):  
Network Analysis ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Neuronal Cells ◽  
Silica Nanoparticle ◽  
Signaling Network ◽  
Mesoporous Silica Nanoparticle

Mesoporous silica nanoparticle (MSN)-mediated glutathione (GSH) delivery for targeted protection of dopaminergic neuronal cells.

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