Synthesis of artemisinin derived glycoconjugates inspired by click chemistry

2019 ◽  
Vol 43 (10) ◽  
pp. 4017-4021 ◽  
Author(s):  
Lakshmi Goswami ◽  
Sayantan Paul ◽  
Tharun K. Kotammagari ◽  
Asish K. Bhattacharya
Keyword(s):  
Click Chemistry ◽  
Click Reactions

Cu(i)-catalysed click reactions between β-propargylated dihydroartemisinin and azido sugars were carried out to furnish artemisinin based glycoconjugates.

CuAAC click reactions for the design of multifunctional luminescent ruthenium complexes

2016 ◽  
Vol 45 (6) ◽  
pp. 2338-2351 ◽  
Author(s):  
Natalia Zabarska ◽  
Anne Stumper ◽  
Sven Rau
Keyword(s):  
Click Chemistry ◽  
Ruthenium Complexes ◽  
Click Reactions ◽  
Versatile Tool ◽  
Potential Applicability

CuAAC (Cu(i) catalyzed azide–alkyne cycloaddition) click chemistry has emerged as a versatile tool in the development of photoactive ruthenium complexes with multilateral potential applicability. Three general concepts for their synthesis and selected applications are discussed.

scholarly journals Orthogonal click reactions enable the synthesis of ECM-mimetic PEG hydrogels without multi-arm precursors

2018 ◽  
Vol 6 (30) ◽  
pp. 4929-4936 ◽  
Author(s):  
Faraz Jivan ◽  
Natalia Fabela ◽  
Zachary Davis ◽  
Daniel L. Alge
Keyword(s):  
Tissue Engineering ◽  
Ethylene Glycol ◽  
Click Chemistry ◽  
Bioactive Peptides ◽  
Poly Ethylene Glycol ◽  
Click Reactions ◽  
Peg Hydrogels ◽  
Poly Ethylene

A two-step, click chemistry approach to create user-defined hydrogels consisting of poly(ethylene glycol) and bioactive peptides without the use of multi-arm precursors for tissue engineering.

Modular synthesis of glycopolymers with well-defined sugar units in the side chain via Ugi reaction and click chemistry: hetero vs. homo

2016 ◽  
Vol 7 (25) ◽  
pp. 4263-4271 ◽  
Author(s):  
Lulu Xue ◽  
Xinhong Xiong ◽  
Kui Chen ◽  
Yafei Luan ◽  
Gaojian Chen ◽  
...  
Keyword(s):  
Click Chemistry ◽  
Ugi Reaction ◽  
Side Chain ◽  
Click Reactions ◽  
Modular Synthesis

Modularized glycopolymers were prepared via Ugi and click reactions, and used as models to investigate their binding abilities.

scholarly journals Facile synthesis of novel hybrid POSS biomolecules via “Click” reactions

RSC Advances ◽  
2017 ◽  
Vol 7 (59) ◽  
pp. 37474-37477 ◽  
Author(s):  
Youssef El Aziz ◽  
Nazia Mehrban ◽  
Peter G. Taylor ◽  
Martin A. Birchall ◽  
James Bowen ◽  
...  
Keyword(s):  
Click Chemistry ◽  
High Yield ◽  
Facile Synthesis ◽  
Click Reactions

A novel alkyne-terminated cubic-octameric POSS was synthesised in high yield and click chemistry has been used to attach bio-oligomers.

scholarly journals Rational linkage of magnetic molecules using click chemistry

2015 ◽  
Vol 51 (30) ◽  
pp. 6524-6527 ◽  
Author(s):  
Christian Plenk ◽  
Jasmin Krause ◽  
Martin Beck ◽  
Eva Rentschler
Keyword(s):  
Quantum Computing ◽  
Click Chemistry ◽  
Synthetic Approach ◽  
Click Reactions ◽  
Magnetic Molecules ◽  
Molecular Arrangement ◽  
First Time

Established CuAAC click reactions are used for the first time to assemble magnetic molecules to an extended molecular arrangement. This novel synthetic approach is expected to be a general approach to link SMMs as an important precondition to realize quantum computing.

Thiol–ene “click” reactions and recent applications in polymer and materials synthesis: a first update

2014 ◽  
Vol 5 (17) ◽  
pp. 4820-4870 ◽  
Author(s):  
Andrew B. Lowe
Keyword(s):  
Click Chemistry ◽  
Polymer Materials ◽  
Materials Synthesis ◽  
Efficient Tool ◽  
Click Reactions ◽  
Previous Review

This contribution serves as an update to a previous review (Polym. Chem.2010,1, 17–36) and highlights recent applications of thiol–ene ‘click’ chemistry as an efficient tool for both polymer/materials synthesis as well as modification.

scholarly journals Role of Click Chemistry in Organic Synthesis

2021 ◽  
Author(s):  
Ayushi Sethiya ◽  
Nusrat Sahiba ◽  
Shikha Agarwal
Keyword(s):  
Click Chemistry ◽  
Organic Synthesis ◽  
Material Science ◽  
Diels Alder ◽  
Organic Reactions ◽  
Ene Reactions ◽  
Click Reactions ◽  
Ring Opening Reactions ◽  
Nucleophilic Ring Opening

Click chemistry involves highly efficient organic reactions of two or more highly functionalized chemical entities under eco-benign conditions for the synthesis of different heterocycles. Several organic reactions such as nucleophilic ring-opening reactions, cyclo-additions, nucleophilic addition reactions, thiol-ene reactions, Diels Alder reactions, etc. are included in click reactions. These reactions have very important features i.e. high functional group tolerance, formation of a single product, high atom economy, high yielding, no need for column purification, etc. It also possesses several applications in drug discovery, supramolecular chemistry, material science, nanotechnology, etc. Being highly significant and valuable, we have elaborated on several aspects of click reactions in organic synthesis in this chapter. Recent advancements in the field of organic synthesis using click chemistry approach have been deliberated by citing last five years articles.

scholarly journals The Use of Click-Type Reactions in the Preparation of Thermosets

Polymers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1084
Author(s):  
Osman Konuray ◽  
Xavier Fernández-Francos ◽  
Silvia De la Flor ◽  
Xavier Ramis ◽  
Àngels Serra
Keyword(s):  
Click Chemistry ◽  
Network Formation ◽  
Polymer Networks ◽  
Click Reactions ◽  
Basic Concepts ◽  
Enhanced Properties ◽  
Polymerization Method ◽  
Advanced Applications

Click chemistry has emerged as an effective polymerization method to obtain thermosets with enhanced properties for advanced applications. In this article, commonly used click reactions have been reviewed, highlighting their advantages in obtaining homogeneous polymer networks. The basic concepts necessary to understand network formation via click reactions, together with their main characteristics, are explained comprehensively. Some of the advanced applications of thermosets obtained by this methodology are also reviewed.

The use of reduced copper metal–organic frameworks to facilitate CuAAC click chemistry

2016 ◽  
Vol 52 (82) ◽  
pp. 12226-12229 ◽  
Author(s):  
Q. Fu ◽  
K. Xie ◽  
S. Tan ◽  
J. M. Ren ◽  
Q. Zhao ◽  
...  
Keyword(s):  
Catalytic Activity ◽  
Click Chemistry ◽  
Structural Stability ◽  
Metal Organic Framework ◽  
Metal Organic Frameworks ◽  
Copper Metal ◽  
Copper Halide ◽  
Click Reactions ◽  
Metal Organic ◽  
Organic Framework

A reduced copper metal–organic framework (rCu-MOF) containing CuI ions was prepared and employed as a catalyst for ‘Click’ reactions. The rCu-MOF presents higher catalytic activity, good structural stability as well as facile recyclability compared to traditional copper halide catalysts.

scholarly journals SYNTHESIS OF MODYFIED FLUORESCEINE FOR CLICK REACTIONS

2020 ◽  
Vol 86 (3) ◽  
pp. 3-8
Author(s):  
Roman Selin ◽  
Viktor Chernii ◽  
Andriy Mokhir
Keyword(s):  
Click Chemistry ◽  
Organic Solvents ◽  
Fluorescent Dyes ◽  
Acid Anhydride ◽  
Quantum Yields ◽  
Biological Media ◽  
Click Reactions ◽  
Isolation And Purification ◽  
Biological Objects ◽  
Poorly Soluble

Reactions of azide-alkilic cycloaddition are well known since 1893. At the same time, with the elaboration of click chemistry, the techniques of labelling biological objects, particularly by fluorescent dyes, were widely developed. The use of fluorescent labels provides the ability to visually monitor the process streamlines hardware load and reduces research time. Fluorescein is among the fluorophores mostly used for labelling of biomolecules due to its high quantum yields and good stability in biological media. However, despite of commercial availability of fluorescein derivatives functionalized for use in click reactions, methods for their synthesis are virtually absent in the literature. Therefore, we have developed a reliable and effective methodic for the synthesis of functionalized fluoresceines for the use in the click reactions. Synthesis of diacetyl N-(4-azidobutyl)-fluoresceine-5(6)-carboxamide was performed in six stages, starting form resorcinol and trimellitic acid anhydride. The diacetylated analogue was synthesized for the click modifications in the “soft” conditions, since N-(4-azidobutyl)-fluorescein-5(6)-carboxamide is poorly soluble in the classic organic solvents. Proposed synthetic protocol allows to increase the yield of the final and intermediate compounds and to optimized the procedure of their isolation and purification.

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