One-pot synthesis of novel functionalized benzodiazepines via three-component or domino reactions
A simple and highly efficient protocol for the one-pot synthesis of novel benzodiazepines, which fused tricyclic or tetracyclic systems containing aryl, carboxyl, ester and acyl groups, was developed. Libraries of 40 new compounds were successfully synthesized via three-component or domino reactions by using a mild catalyst (γ-Fe2O3@SiO2/CeCl3) in good to excellent yields (82–97%).
Silica nanoparticles as a highly efficient catalyst for the one-pot synthesis of sterically congested 2-(dibenzylamino)-2-aryl acetamide derivatives from by phthaldehyde isomers, isocyanides and dibenzylamine