Chemoselective phosphine-catalyzed cyanoacylation of α-dicarbonyl compounds: a general method for the synthesis of cyanohydrin esters with one quaternary stereocenter

2018 ◽  
Vol 42 (24) ◽  
pp. 19720-19728 ◽  
Author(s):  
Honghui Zhang ◽  
Rongfang Liu ◽  
Jialin Liu ◽  
Binbin Fan ◽  
Ruifeng Li ◽  
...  
Keyword(s):  
Dicarbonyl Compounds ◽  
Quaternary Stereocenter ◽  
General Method

A chemoselective phosphine-catalyzed cyanoacylation of α-dicarbonyl compounds with acyl cyanides is reported.

Efficient Biginelli Synthesis of 2-Aminodihydropyrimidines under Microwave Irradiation

Synlett ◽  
2018 ◽  
Vol 29 (08) ◽  
pp. 1047-1054 ◽  
Author(s):  
Fulvia Felluga ◽  
Fabio Benedetti ◽  
Federico Berti ◽  
Sara Drioli ◽  
Giorgia Regini
Keyword(s):  
Microwave Irradiation ◽  
Guanidine Hydrochloride ◽  
Reaction Times ◽  
Conventional Heating ◽  
Dicarbonyl Compounds ◽  
Simple Protocol ◽  
Twofold Excess ◽  
General Method

A practical and general method for the Biginelli cyclocondensation of guanidine with aldehydes and β-dicarbonyl compounds is described and illustrated with the synthesis of a set of 26 functionalized 2-amino-3,4-dihydropyrimidines. The simple protocol involves the ­microwave-mediated reaction of a twofold excess of guanidine hydrochloride with the required reaction partners in an alcohol at 120 °C. Yields are generally good, with short reaction times and a simple workup. The scope is considerably wider than that of similar reactions ­carried out under conventional heating.

A general method of synthesis of functionalized Z-vinylic tellurides starting from β-dicarbonyl compounds

Tetrahedron ◽  
2002 ◽  
Vol 58 (6) ◽  
pp. 1051-1059 ◽  
Author(s):  
Rafael E Barrientos-Astigarraga ◽  
Priscila Castelani ◽  
Celso Y Sumida ◽  
Julio Zukerman-Schpector ◽  
João V Comasseto
Keyword(s):  
Dicarbonyl Compounds ◽  
General Method

scholarly journals Enantio- and diastereoselective diarylmethylation of 1,3-dicarbonyl compounds

2020 ◽  
Vol 11 (23) ◽  
pp. 5969-5973
Author(s):  
Xin Li ◽  
Songtao He ◽  
Qiuling Song
Keyword(s):  
Atom Economy ◽  
Dicarbonyl Compounds ◽  
Quaternary Stereocenter

A Cu-catalyzed enantio- and diastereoselective diarylmethylation of 1,3-dicarbonyl compounds is described. Two contiguous stereocenters including one all-carbon quaternary stereocenter are constructed with good stereoselectivity and atom economy.

ChemInform Abstract: A General Method of Synthesis of Functionalized Z-Vinylic Tellurides Starting from β-Dicarbonyl Compounds.

ChemInform ◽  
2010 ◽  
Vol 33 (28) ◽  
pp. no-no
Author(s):  
Rafael E. Barrientos-Astigarraga ◽  
Priscila Castelani ◽  
Celso Y. Sumida ◽  
Julio Zukerman-Schpector ◽  
Joao V. Comasseto
Keyword(s):  
Dicarbonyl Compounds ◽  
General Method

A General Method for Spectrometer Design in the Scoff Approximation

1976 ◽  
Vol 34 ◽  
pp. 538-539
Author(s):  
J. R. Fields
Keyword(s):  
Electron Microscope ◽  
Transmission Electron Microscope ◽  
Energy Analysis ◽  
Incident Beam ◽  
Scanning Transmission Electron Microscope ◽  
Chemical Identification ◽  
Scanning Transmission Electron ◽  
Transmission Electron ◽  
Scanning Transmission ◽  
General Method

The energy analysis of electrons scattered by a specimen in a scanning transmission electron microscope can improve contrast as well as aid in chemical identification. In so far as energy analysis is useful, one would like to be able to design a spectrometer which is tailored to his particular needs. In our own case, we require a spectrometer which will accept a parallel incident beam and which will focus the electrons in both the median and perpendicular planes. In addition, since we intend to follow the spectrometer by a detector array rather than a single energy selecting slit, we need as great a dispersion as possible. Therefore, we would like to follow our spectrometer by a magnifying lens. Consequently, the line along which electrons of varying energy are dispersed must be normal to the direction of the central ray at the spectrometer exit.

Phase behavior of cationic and anionic surfactants at low concentrations

1992 ◽  
Vol 50 (1) ◽  
pp. 694-695
Author(s):  
E. Naranjo
Keyword(s):  
Phase Behavior ◽  
Structural Characterization ◽  
Dynamic Systems ◽  
Anionic Surfactants ◽  
Intermolecular Forces ◽  
Stable Form ◽  
Surfactant Mixtures ◽  
Low Concentrations ◽  
Cationic And Anionic Surfactants ◽  
General Method

Equilibrium vesicles, those which are the stable form of aggregation and form spontaneously on mixing surfactant with water, have never been demonstrated in single component bilayers and only rarely in lipid or surfactant mixtures. Designing a simple and general method for producing spontaneous and stable vesicles depends on a better understanding of the thermodynamics of aggregation, the interplay of intermolecular forces in surfactants, and an efficient way of doing structural characterization in dynamic systems.

Dicarbonyl derived post-translational modifications: chemistry bridging biology and aging-related disease

2020 ◽  
Vol 64 (1) ◽  
pp. 97-110
Author(s):  
Christian Sibbersen ◽  
Mogens Johannsen
Keyword(s):  
Mass Spectrometry ◽  
Future Research ◽  
Amino Acid Residues ◽  
Post Translational Modification ◽  
Dicarbonyl Compounds ◽  
Protein Targets ◽  
Post Translational Modifications ◽  
Reactive Protein ◽  
Glycation End Products ◽  
Direct Mass Spectrometry

Abstract In living systems, nucleophilic amino acid residues are prone to non-enzymatic post-translational modification by electrophiles. α-Dicarbonyl compounds are a special type of electrophiles that can react irreversibly with lysine, arginine, and cysteine residues via complex mechanisms to form post-translational modifications known as advanced glycation end-products (AGEs). Glyoxal, methylglyoxal, and 3-deoxyglucosone are the major endogenous dicarbonyls, with methylglyoxal being the most well-studied. There are several routes that lead to the formation of dicarbonyl compounds, most originating from glucose and glucose metabolism, such as the non-enzymatic decomposition of glycolytic intermediates and fructosyl amines. Although dicarbonyls are removed continuously mainly via the glyoxalase system, several conditions lead to an increase in dicarbonyl concentration and thereby AGE formation. AGEs have been implicated in diabetes and aging-related diseases, and for this reason the elucidation of their structure as well as protein targets is of great interest. Though the dicarbonyls and reactive protein side chains are of relatively simple nature, the structures of the adducts as well as their mechanism of formation are not that trivial. Furthermore, detection of sites of modification can be demanding and current best practices rely on either direct mass spectrometry or various methods of enrichment based on antibodies or click chemistry followed by mass spectrometry. Future research into the structure of these adducts and protein targets of dicarbonyl compounds may improve the understanding of how the mechanisms of diabetes and aging-related physiological damage occur.

Caricaturing as a general method to improve poor face recognition: Evidence from low-resolution images, other-race faces, and older adults.

2019 ◽  
Vol 25 (2) ◽  
pp. 256-279 ◽  
Author(s):  
Amy Dawel ◽  
Tsz Ying Wong ◽  
Jodie McMorrow ◽  
Callin Ivanovici ◽  
Xuming He ◽  
...  
Keyword(s):  
Older Adults ◽  
Face Recognition ◽  
Low Resolution ◽  
General Method ◽  
Low Resolution Images

Morphosemantic Analysis and Translation of Medical Compound Terms

1991 ◽  
Vol 30 (01) ◽  
pp. 30-35 ◽  
Author(s):  
P. Dujols ◽  
P. Aubas ◽  
C. Baylon ◽  
F. Grémy
Keyword(s):  
Medical Terms ◽  
General Method

This paper describes an automatic procedure for morphosemantic analysis and translation of compound medical terms. This analysis is of interest for the automatic indexation of medical discharge reports and summaries. Since words with the suffix -osis may have many different semantic interpretations, such -osis forms are taken as examples for a general method that avoids the difficulties in interpreting medical terms as reported in other studies.

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