Synthesis, structures, antimicrobial activity and biosafety evaluation of pyridine-2-formaldehyde-N-susbtituted-thiosemicarbazonates of copper(ii)

2018 ◽  
Vol 42 (19) ◽  
pp. 15879-15894 ◽  
Author(s):  
Mani Kaushal ◽  
Tarlok S. Lobana ◽  
Lovedeep Nim ◽  
Jaskamal Kaur ◽  
Ritu Bala ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Cell Viability ◽  
High Cell ◽  
Antimicrobial Potential ◽  
Microbial Strains ◽  
Biosafety Evaluation

Copper(ii) complexes with pyridine based thiosemicarbazones have shown high antimicrobial potential against different microbial strains, and were found to be biosafe with several complexes displaying high cell viability (90–98%).

Synthesis, antimicrobial activity and high cell viability of copper derivatives of 2-thiouracil, purine-6-thione and 2,4,6-trimercaptotriazine

2019 ◽  
Vol 72 (3) ◽  
pp. 438-451 ◽  
Author(s):  
Jaspreet Kaur Aulakh ◽  
Samridhi Sharma ◽  
Henna Sood ◽  
Daljit S. Arora ◽  
Manpreet Kaur ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Cell Viability ◽  
High Cell ◽  
Derivatives Of

The In vitro Evaluation of the Antimicrobial Activity of Quercus robur L. Methanolic and Aqueous Leaves’ Extracts, from the Algerian High Plateaus Against some Uropathogenic Microbial Strains

2019 ◽  
Vol 18 (5) ◽  
pp. 262-274
Author(s):  
E. Benyagoub ◽  
N. Nabbou ◽  
S. Boukhalkhel ◽  
I. Dehini
Keyword(s):  
Escherichia Coli ◽  
Staphylococcus Aureus ◽  
Antimicrobial Activity ◽  
Candida Albicans ◽  
Enterococcus Faecalis ◽  
Fusidic Acid ◽  
Quercus Robur ◽  
Diffusion Method ◽  
Phytochemical Analysis ◽  
Microbial Strains

The medicinal value of the plants is due to their chemical components that bring a definite physiological action on the human body to prevent the diseases. In this work, we investigated the antimicrobial activity of leaves’ extracts of Quercus robur L., collected from the Algerian upper highlands, on ten bacterial strains and one fungal strain known to be pathogenic. First, we performed a qualitative phytochemical analysis, and second, antimicrobial activity tests performed by agar diffusion method (disc and well) with the determination of MIC by broth macro-dilution method. Given the results, it appears that obtained macerates of Quercus robur L. were rich in bioactive phytoconstituents such as alkaloids, anthraquinones, saponins, tannins, and other components. The yield of aqueous and methanolic macerates of leaves was 8.5 ± 1.41 and 22.4 ± 4.36%, respectively. The bacterial resistance was relatively important to several antibiotics, namely, ampicillin, amoxicillin + clavulanic acid for strains of Escherichia coli and Salmonella sp. However, Staphylococcus aureus strains were resistant to fusidic acid, penicillin, and oxacillin; while Enterococcus faecalis was resistant to fusidic acid, penicillin, oxacillin, and ticarcillin. The antibacterial activity of the macerates toward tested microbial strains showed that the aqueous and methanolic macerates of the leaves were proportional to the tested concentration and active not only against Gram-positive and Gram-negative bacteria but also on the fungal species Candida albicans. The estimated MIC for Escherichia coli, Enterococcus faecalis, and Staphylococcus aureus was in the order of 10 mg/mL, which seems more effective than toward Salmonella sp., Klebsiella pneumoniae, Pseudomonas aeruginosa, and Candida albicans which were in the order of 30 mg/mL. These preliminary results confirm that the part of the studied plant had a very good antimicrobial activity that was proportional to the serial concentrations of the tested extracts.

The 3D printing of gelatin methacrylamide cell-laden tissue-engineered constructs with high cell viability

Biomaterials ◽  
2014 ◽  
Vol 35 (1) ◽  
pp. 49-62 ◽  
Author(s):  
Thomas Billiet ◽  
Elien Gevaert ◽  
Thomas De Schryver ◽  
Maria Cornelissen ◽  
Peter Dubruel
Keyword(s):  
3D Printing ◽  
Cell Viability ◽  
High Cell

scholarly journals Anticancer and Antimicrobial Activity Evaluation of Cowpea-Porous-Starch-Formulated Silver Nanoparticles

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Shiara Ramdath ◽  
John Mellem ◽  
Londiwe Simphiwe Mbatha
Keyword(s):  
Antimicrobial Activity ◽  
Silver Nanoparticles ◽  
Cell Viability ◽  
High Dose ◽  
Bacterial Strains ◽  
Gram Positive ◽  
Gram Negative ◽  
Anticancer Drug Delivery ◽  
Ic50 Values ◽  
Biosynthesized Agnps

Health issues involving inadequate treatment of diseases such as cancer and microbial infections continue to be the subject of much ongoing recent research. Biosynthesized silver nanoparticles (AgNPs) were characterized using Transmission Electron Microscopy (TEM), Zeta Sizer, Ultraviolet (UV), and Fourier Transform Infrared (FTIR) spectroscopy. Their antimicrobial activity was evaluated on selected Gram-positive and Gram-negative bacterial strains, using the disc diffusion and broth dilution assays. Cell viability profiles were evaluated using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and apoptosis studies on selected human noncancer and cancer cells. The biosynthesized AgNPs were evaluated to be spherical clusters, with sizes between 40 and 70 nm. The absorption peak at 423 nm and the presence of polyphenols confirmed the synthesis and stabilization of these tested AgNPs. The AgNPs showed a good stability of −23.9 ± 1.02 mV. Good antimicrobial activity (6.0–18.0 mm) was seen on all tested bacteria at a minimum inhibitory concentration (MIC) ranging from 5 to 16 μg/ml, with the highest activity seen against Gram-negative Escherichia coli (18 ± 0.5 mm), and the lowest activity was seen against Gram-positive Listeria monocytogenes (6.0 ± 0.4 mm) after treatment with the AgNPs. These NPs showed a concentration-dependent and cell-specific cytotoxicity with low IC50 values (41.7, 56.3, and 63.8 μg/ml). The NPs were well tolerated by tested cells as indicated by a more than 50% cell viability at the high dose tested and low apoptotic indices (<0.2). These findings indicated that these biosynthesized AgNPs showed great potential as effective antibacterial agents and anticancer drug delivery modalities.

scholarly journals Development of Novel Thin Polycaprolactone (PCL)/Clay Nanocomposite Films with Antimicrobial Activity Promoted by the Study of Mechanical, Thermal, and Surface Properties

Polymers ◽  
2021 ◽  
Vol 13 (18) ◽  
pp. 3193
Author(s):  
Sylva Holešová ◽  
Karla Čech Čech Barabaszová ◽  
Marianna Hundáková ◽  
Michaela Ščuková ◽  
Kamila Hrabovská ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Surface Properties ◽  
Food Packaging ◽  
Synergistic Effects ◽  
Nanocomposite Films ◽  
Mechanical Resistance ◽  
X Ray Diffraction ◽  
Microbial Strains ◽  
And Storage ◽  
Structure Properties

Infection with pathogenic microorganisms is of great concern in many areas, especially in healthcare, but also in food packaging and storage, or in water purification systems. Antimicrobial polymer nanocomposites have gained great popularity in these areas. Therefore, this study focused on new approaches to develop thin antimicrobial films based on biodegradable polycaprolactone (PCL) with clay mineral natural vermiculite as a carrier for antimicrobial compounds, where the active organic antimicrobial component is antifungal ciclopirox olamine (CPX). For possible synergistic effects, a sample in combination with the inorganic antimicrobial active ingredient zinc oxide was also prepared. The structures of all the prepared samples were studied by X-ray diffraction, FTIR analysis and, predominantly, by SEM. The very different structure properties of the prepared nanofillers had a fundamental influence on the final structural arrangement of thin PCL nanocomposite films as well as on their mechanical, thermal, and surface properties. As sample PCL/ZnOVER_CPX possessed the best results for antimicrobial activity against examined microbial strains, the synergic effect of CPX and ZnO combination on antimicrobial activity was proved, but on the other hand, its mechanical resistance was the lowest.

scholarly journals Antimicrobial activity of Satureja hortensis L. essential oil against pathogenic microbial strains

2010 ◽  
Vol 62 (1) ◽  
pp. 159-166 ◽  
Author(s):  
Tatjana Mihajilov-Krstev ◽  
Dragan Radnovic ◽  
Dusanka Kitic ◽  
Zorica Stojanovic-Radic ◽  
Bojan Zlatkovic
Keyword(s):  
Antimicrobial Activity ◽  
Essential Oil ◽  
Wide Spectrum ◽  
Significant Activity ◽  
Fungal Strains ◽  
Satureja Hortensis ◽  
Conservation Treatment ◽  
Microbial Strains ◽  
Editorial Decision ◽  
Font Color

A hydro-distilled oil of Satureja hortensis L. was investigated for its antimicrobial activity against a panel of 11 bacterial and three fungal strains. The antimicrobial activity was determined using the disk-diffusion and broth microdilution methods. The essential oil of S. hortensis L. showed significant activity against a wide spectrum of Gram (-) bacteria (MIC/MBC=0.025-0.78/0.05-0.78 ?l/ml) and Gram (+) bacteria (MIC/MBC=0.05-0.39/0.05-0.78 ?l/ml), as well as against fungal strains (MIC/MBC=0.20/0.78 ?l/ml). The results indicate that this oil can be used in food conservation, treatment of different diseases of humans, and also for the treatment of plants infected by phytopathogens. <br><br><b><font color="red">Detected autoplagiarism. Link to the Editorial Decision <u><a href="http://dx.doi.org/10.2298/ABS1004251U">10.2298/ABS1004251U</a></u></font></b><br>

Synthesis, structures, and ESI-mass studies of silver(I) derivatives of imidazolidine-2-thiones: Antimicrobial potential and biosafety evaluation

2018 ◽  
Vol 178 ◽  
pp. 18-31 ◽  
Author(s):  
Jaspreet K. Aulakh ◽  
Tarlok S. Lobana ◽  
Henna Sood ◽  
Daljit S. Arora ◽  
Victoria A. Smolinski ◽  
...  
Keyword(s):  
Antimicrobial Potential ◽  
Derivatives Of ◽  
Biosafety Evaluation

Isolation and screening of microbial strains for potential antimicrobial activity

2018 ◽  
Vol 44 ◽  
pp. S119
Author(s):  
C. Tomulescu ◽  
R. Stoica ◽  
I. Nicu ◽  
G. Iordache ◽  
M. Moscovici
Keyword(s):  
Antimicrobial Activity ◽  
Microbial Strains ◽  
Potential Antimicrobial Activity

scholarly journals Antimicrobial Activity of neo-Clerodane Diterpenoids isolated from Lamiaceae Species against Pathogenic and Food Spoilage Microorganisms

2015 ◽  
Vol 10 (11) ◽  
pp. 1934578X1501001 ◽  
Author(s):  
Petko Bozov ◽  
Tania Girova ◽  
Natalia Prisadova ◽  
Yana Hristova ◽  
Velizar Gochev
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Activity ◽  
Food Spoilage ◽  
Aerial Parts ◽  
Spoilage Bacteria ◽  
Microbial Strains ◽  
Clerodane Diterpenoids ◽  
Acetone Extracts ◽  
And Staphylococcus Aureus ◽  
Spoilage Microorganisms

Antimicrobial activity of nineteen neo-clerodane diterpenoids, isolated from the acetone extracts of the aerial parts of Scutellaria and Salvia species (Lamiaceae) were tested against thirteen strains belonging to nine different species of pathogenic and food spoilage bacteria Aeromonas hydrophila, Bacillus cereus, Escherichia coli, Listeria monocytogenes, Proteus vulgaris, Pseudomonas aeruginosa, Pseudomonas fluorescens, Salmonella abony and Staphylococcus aureus as well as against two yeast strains belonging to species Candida albicans. Seven of the evaluated compounds scutalpin A, scutalpin E, scutalpin F, salviarin, splenolide A, splenolide B and splendidin demonstrated antimicrobial activity against used test microbial strains, the rest of the compounds were inactive within the studied concentration range. Among all of the tested compounds the highest antimicrobial activity was detected for scutalpin A against Staphylococcus aureus (MIC 25 μg/mL).

scholarly journals Phytochemical Profile and Evaluation of the Antimicrobial Activity of Echinodorus grandiflorus Crude Extract of the Leaves

2020 ◽  
Vol 8 (4) ◽  
pp. 176
Author(s):  
Carla Indianara Bonetti ◽  
Mariana Dalmagro ◽  
Juliana Cristhina Friedrich ◽  
Douglas Rossi Jesus ◽  
Mariana Moraes Pinc ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Crude Extract ◽  
Lactobacillus Casei ◽  
Inhibitory Concentration ◽  
Chemical Compounds ◽  
Diffusion Method ◽  
Disk Diffusion Method ◽  
Microbial Strains ◽  
Cardioprotective Effects ◽  
Phytochemical Profile

Echinodorus grandiflorus has pharmacological properties due to its secondary metabolism, such as anti-inflammatory, antioxidant, diuretic, analgesic, anti-rheumatic, antihypertensive, and cardioprotective effects. The aim of this study was to determine the phytochemical profile and evaluate the antimicrobial activity of crude extract of E. grandiflorus form its leaves. In the analysis of the phytochemical profile, qualitative tests were performed to identify tannins, alkaloids, flavonoids, anthraquinones, steroids, triterpenes, saponins, polysaccharides, and coumarins. Antimicrobial tests were performed using the disk diffusion method and minimum inhibitory concentration (MIC) in 96-well microplates, using hydroalcoholic crude extract obtained by maceration in the proportions 1:5 and 1:10. The higher content of crude extract was observed by maceration 1:5 (3.26%). In phytochemical tests, the presence of tannins, alkaloids, flavonoids, and saponins was detected. The microbial strains evaluated were Staphylococcus aureus, S. epidermidis, Lactobacillus casei, Bacillus cereus, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans. The antimicrobial activity of crude extract has not apparent against the tested organisms. It is concluded that the crude extract present several phytochemical, however did not show antimicrobial activity, and furthermore studies should be carried out researching isolated chemical compounds and the antimicrobial activity leaves crude extract of Echinodorus grandiflorus plant.

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