Electrically conductive nanocomposite hydrogels embedded with functionalized carbon nanotubes for spinal cord injury

2018 ◽  
Vol 42 (21) ◽  
pp. 17671-17681 ◽  
Author(s):  
Xifeng Liu ◽  
Joseph C. Kim ◽  
A. Lee Miller ◽  
Brian E. Waletzki ◽  
Lichun Lu
Keyword(s):  
Carbon Nanotubes ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cell Growth ◽  
Electrically Conductive ◽  
Functionalized Carbon Nanotubes ◽  
Nanocomposite Hydrogels ◽  
Cord Injury ◽  
Cell Growth And Differentiation ◽  
Conductive Hydrogels

Electrically conductive hydrogels incorporated with CNTs support PC12 cell growth and differentiation and hold promise for nerve regeneration.

scholarly journals Endogenous ET-1 initiates astrocytic cell growth after spinal cord injury

1996 ◽  
Vol 71 ◽  
pp. 282
Author(s):  
Masafumi Uesugil ◽  
Yoshitoshi Kasuya ◽  
Hiroshi Hama ◽  
Miyuki Yamamoto ◽  
Kohichiroh Hayashi ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cell Growth ◽  
Cord Injury

scholarly journals Exosome-loaded conductive hydrogel with immune-modulating and neurogenesis-enhancing properties for synergistic spinal cord injury repair

2020 ◽  
Author(s):  
Lei Fan ◽  
Can Liu ◽  
Xiuxing Chen ◽  
Yan Zou ◽  
Huiquan Wen ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Early Stage ◽  
Neural Tissue ◽  
Oligodendrocyte Differentiation ◽  
Conductive Hydrogel ◽  
Cord Injury ◽  
Astrocyte Differentiation ◽  
Conductive Hydrogels ◽  
Marrow Stem Cell

Abstract Conductive hydrogels are very attractive candidates for accelerated spinal cord injury (SCI) repair because they match the electrical and mechanical properties of neural tissue. However, conductive hydrogel implantation can potentially aggravate inflammation, and hinder its repair efficacy. Bone marrow stem cell-derived exosomes (BMSC-exos) have shown immunomodulatory and tissue regeneration effects, therefore, we developed neural tissue-like conductive hydrogels loaded with BMSC-exos for the synergistic treatment of SCI. These exos-loaded conductive hydrogels modulated microglial M2 polarization via the NF-κB pathway, and synergistically enhanced neuronal and oligodendrocyte differentiation of neural stem cells (NSCs) while inhibiting astrocyte differentiation, and also increased axon outgrowth via the PTEN/PI3K/AKT/mTOR pathway. Furthermore, exos combined conductive hydrogels significantly decreased the number of CD68-positive microglia, enhanced local neurogenesis, and promoted axonal regeneration, resulting in significant functional recovery at the early stage in an SCI mouse model. Hence, the findings of this study demonstrate that the combination of conductive hydrogels and BMSC-exos is a promising therapeutic strategy for SCI repair.

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