Chemoenzymatic synthesis of a cholesterol-g-poly(amine-co-ester) carrier for p53 gene delivery to inhibit the proliferation and migration of tumor cells

2018 ◽  
Vol 42 (16) ◽  
pp. 13541-13548 ◽  
Author(s):  
Mengmeng Dong ◽  
Jiawen Chen ◽  
Jiebing Yang ◽  
Wei Jiang ◽  
Haobo Han ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Tumor Cells ◽  
P53 Gene ◽  
Chemoenzymatic Synthesis ◽  
And Migration ◽  
Proliferation And Migration

An amphiphilic cholesterol-g-poly(amine-co-ester) synthesizedviaa chemoenzymatic route has been successfully applied as a carrier in p53 gene delivery.

Inhibition of proliferation and migration of tumor cells through lipoic acid-modified oligoethylenimine-mediated p53 gene delivery

2019 ◽  
Vol 43 (6) ◽  
pp. 2758-2765
Author(s):  
Xiuhui Tang ◽  
Qing Li ◽  
Xiao Liang ◽  
Jiebing Yang ◽  
Ziling Liu ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Tumor Cells ◽  
Lipoic Acid ◽  
P53 Gene ◽  
Inhibition Of Proliferation ◽  
And Migration ◽  
Proliferation And Migration

Inhibition of proliferation and migration of tumor cells through lipoic acid-modified oligoethylenimine-mediated p53 gene delivery.

scholarly journals Down-regulated LncR-MALAT1 suppressed cell proliferation and migration by inactivating autophagy in bladder cancer

RSC Advances ◽  
2018 ◽  
Vol 8 (54) ◽  
pp. 31019-31027
Author(s):  
Jiude Qi ◽  
Yanfeng Chu ◽  
Guangyan Zhang ◽  
Hongjun Li ◽  
Dongdong Yang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Bladder Cancer ◽  
Lung Adenocarcinoma ◽  
Tumor Cells ◽  
Cell Proliferation And Migration ◽  
Non Coding Rna ◽  
And Migration ◽  
Long Non Coding Rna ◽  
Proliferation And Migration

Long non-coding RNA-metastasis-associated lung adenocarcinoma transcript (LncR-MALAT) is highly expressed in a variety of tumors, which can affect the progression of tumor cells.

scholarly journals Aberrant CD137 ligand expression induced by GATA6 overexpression promotes tumor progression in cutaneous T-cell lymphoma

Blood ◽  
2018 ◽  
Vol 132 (18) ◽  
pp. 1922-1935 ◽  
Author(s):  
Hiroaki Kamijo ◽  
Tomomitsu Miyagaki ◽  
Naomi Shishido-Takahashi ◽  
Rina Nakajima ◽  
Tomonori Oka ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Tumor Cells ◽  
Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
Promote Cell Proliferation ◽  
Cell Proliferation And Migration ◽  
Key Points ◽  
Ligand Expression ◽  
And Migration ◽  
Proliferation And Migration

Key Points Overexpression of GATA6 induces aberrant CD137L expression on tumor cells of CTCL. CD137-CD137L interactions promote cell proliferation and migration in CTCL cells, representing potential therapeutic targets.

scholarly journals Inhibiting IRE1α-endonuclease activity decreases tumor burden in a mouse model for hepatocellular carcinoma

eLife ◽  
2020 ◽  
Vol 9 ◽  
Author(s):  
Nataša Pavlović ◽  
Carlemi Calitz ◽  
Kess Thanapirom ◽  
Guiseppe Mazza ◽  
Krista Rombouts ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Cells ◽  
Cell Activation ◽  
Stellate Cell ◽  
Stellate Cells ◽  
Tumor Burden ◽  
And Migration ◽  
Hcc Cells ◽  
Proliferation And Migration

Hepatocellular carcinoma (HCC) is a liver tumor that usually arises in patients with cirrhosis. Hepatic stellate cells are key players in the progression of HCC, as they create a fibrotic micro-environment and produce growth factors and cytokines that enhance tumor cell proliferation and migration. We assessed the role of endoplasmic reticulum (ER) stress in the cross-talk between stellate cells and HCC cells. Mice with a fibrotic HCC were treated with the IRE1α-inhibitor 4μ8C, which reduced tumor burden and collagen deposition. By co-culturing HCC-cells with stellate cells, we found that HCC-cells activate IREα in stellate cells, thereby contributing to their activation. Inhibiting IRE1α blocked stellate cell activation, which then decreased proliferation and migration of tumor cells in different in vitro 2D and 3D co-cultures. In addition, we also observed cell-line-specific direct effects of inhibiting IRE1α in tumor cells.

Silibinin Inhibit Cell Migration through Downregulation of RAC1 Gene Expression in Highly Metastatic Breast Cancer Cell Line

Drug Research ◽  
2020 ◽  
Vol 70 (10) ◽  
pp. 478-483
Author(s):  
Hamed Esmaeil Lashgarian ◽  
Vahid Adamii ◽  
Vajihe Ghorbanzadeh ◽  
Leila Chodari ◽  
Fayze Kamali ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Line ◽  
Tumor Cells ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cell Line ◽  
Cancer Cell Line ◽  
Migration And Invasion ◽  
And Migration ◽  
Proliferation And Migration

Abstract Background Triple negative breast cancer is the most invasive breast cancer subtype and possesses poor prognosis and survival. Rho GTPase famil, especially Rac1 participates in a number of signaling events in cells with crucial roles in malignancy, migration and invasion of tumor cells. Silibinin, a flavonoid antioxidant from milk thistle has attracted attention in the recent decades for chemoprevention and chemotherapy of tumor cells. In this study, the effect of silibinin on the migration capacity of MDA-MB-231 cells, a highly metastatic human breast cancer cell line was investigated by evaluation of Rac1 expression. Method MTT wound healing and transwell assays were performed to evaluate the effects of silibinin on proliferation and migration of MDA-MB-231 cells. In addition, the influence of the silibinin on the expression of Rac1mRNAs was assessed by RT-PCR. Results Results indicated significant dose-dependent inhibitory effect of silibinin on proliferation and migration of MDA-MB-231 cells. It significantly inhibited the expression of Rac1 mRNA. Conclusion In conclusion, the results demonstrate that the silibinin can be used as an experimental therapeutic for the management of TNBC metastatic cancer.

Inhibition of Tumor Cells Proliferation and Migration by the Flavonoid Furin Inhibitor Isolated From Oroxylum indicum

2013 ◽  
Vol 20 (4) ◽  
pp. 583-591 ◽  
Author(s):  
C. Lalou ◽  
A. Basak ◽  
P. Mishra ◽  
B.C. Mohanta ◽  
R. Banik ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Oroxylum Indicum ◽  
And Migration ◽  
Proliferation And Migration

Medicinal Value and Potential Therapeutic Mechanisms of Gynostemma pentaphyllum (Thunb.) Makino and Its Derivatives: An Overview

2020 ◽  
Vol 19 (31) ◽  
pp. 2855-2867 ◽  
Author(s):  
Kaijun Li ◽  
Chao Ma ◽  
Haoyu Li ◽  
Sooranna Dev ◽  
JianFeng He ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Herbal Drugs ◽  
Gynostemma Pentaphyllum ◽  
Regulation Effect ◽  
Bidirectional Regulation ◽  
Medicinal Value ◽  
Long Time ◽  
Therapeutic Mechanisms ◽  
And Migration ◽  
Proliferation And Migration

: Gynostemma pentaphyllum (Thunb.) Makino (GpM) and its derivatives, especially gypenosides (Gyps), are widely used as safe and convenient natural herbal drugs for the treatment of many diseases for a long time, and Gyps have different oral bioavailability (OB) values and low ability to cross the blood-brain barrier (BBB). The effects of GpM and isolates on fibrosis, inflammation, oxidation, proliferation and migration are proved. GpM shows bidirectional regulation effect on proliferation, oxidation and apoptosis in tumor and non-tumor cells. GpM and its extractions can resist proliferation, activate oxidation and apoptosis in tumor cells and have opposite effects on non-tumor cells. We succinctly present some current views of medicinal value and potential therapeutic mechanisms of GpM and its derivatives.

scholarly journals B7-H6, an immunoligand for the natural killer cell activating receptor NKp30, reveals inhibitory effects on cell proliferation and migration, but not apoptosis, in cervical cancer derived-cell lines

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Nehla Banu ◽  
Annie Riera-Leal ◽  
Jesse Haramati ◽  
Pablo Cesar Ortiz-Lazareno ◽  
Sandeep Surendra Panikar ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Flow Cytometry ◽  
Cell Proliferation ◽  
Tumor Cell ◽  
Tumor Cells ◽  
Cell Lines ◽  
Cellular Localization ◽  
Cell Proliferation And Migration ◽  
And Migration ◽  
Proliferation And Migration

Abstract Background Although great progress has been made in treatment regimens, cervical cancer remains as one of the most common cancer in women worldwide. Studies focusing on molecules that regulate carcinogenesis may provide potential therapeutic strategies for cervical cancer. B7-H6, an activating immunoligand expressed by several tumor cells, is known to activate NK cell-mediated cytotoxicity once engaged with its natural receptor NKp30. However, the opposite, that is, the effects in the tumor cell triggered by B7-H6 after interacting with NKp30 has not yet been well explored. Methods In this study, we evaluated the surface expression of B7-H6 by flow cytometry. Later, we stimulated B7-H6 positive cervical cancer derived-cell lines (HeLa and SiHa) with recombinant soluble NKp30 (sNKp30) protein and evaluated biological effects using the impedance RTCA system for cell proliferation, the scratch method for cell migration, and flow cytometry for apoptosis. Cellular localization of B7-H6 was determined using confocal microscopy. Results Notably, we observed that the addition of sNKp30 to the cervical cancer cell lines decreased tumor cell proliferation and migration rate, but had no effect on apoptosis. We also found that B7-H6 is selectively maintained in tumor cell lines, and that efforts to sort and purify B7-H6 negative or positive cells were futile, as negative cells, when cultured, regained the expression of B7-H6 and B7-H6 positive cells, when sorted and cultivated, lost a percentage of B7-H6 expression. Conclusions Our results suggest that B7-H6 has an important, as of yet undescribed, role in the biology of the cervical tumor cells themselves, suggesting that this protein might be a promising target for anti-tumor therapy in the future.

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