Modulation of biomimetic properties of cerium oxide nanoparticles by hypoxic tumor microenvironments: steering towards tumor specificity

2018 ◽  
Vol 42 (8) ◽  
pp. 6370-6380 ◽  
Author(s):  
Preethi Sridharan ◽  
G. Vinothkumar ◽  
Pooja Pratheesh ◽  
K. Suresh Babu
Keyword(s):  
Antioxidant Activity ◽  
Cerium Oxide ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Redox Transformation ◽  
Tumor Microenvironments ◽  
Tumor Specificity ◽  
Hypoxic Tumor

Cerium oxide nanoparticles exhibit selective cytotoxic and biomimetic antioxidant activity due to the redox transformation between Ce3+ ↔ Ce4+ states under tumor-like conditions.

scholarly journals In Vitro and In Vivo Antioxidant Activity of the New Magnetic-Cerium Oxide Nanoconjugates

Nanomaterials ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 1565 ◽  
Author(s):  
Turin-Moleavin ◽  
Fifere ◽  
Lungoci ◽  
Rosca ◽  
Coroaba ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Iron Oxide ◽  
Cerium Oxide ◽  
Chemical Activation ◽  
Radical Scavenging ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles

Background. Cerium oxide nanoparticles present the mimetic activity of superoxide dismutase, being able to inactivate the excess of reactive oxygen species (ROS) correlated with a large number of pathologies, such as stents restenosis and the occurrence of genetic mutations that can cause cancer. This study presents the synthesis and biological characterisation of nanoconjugates based on nanoparticles of iron oxide interconnected with cerium oxide conjugates. Methods. The synthesis of magnetite-nanoceria nanoconjugates has been done in several stages, where the key to the process is the coating of nanoparticles with polyethyleneimine and its chemical activation-reticulation with glutaraldehyde. The nanoconjugates are characterised by several techniques, and the antioxidant activity was evaluated in vitro and in vivo. Results. Iron oxide nanoparticles interconnected with cerium oxide nanoparticles were obtained, having an average diameter of 8 nm. Nanoconjugates prove to possess superparamagnetic properties and the saturation magnetisation varies with the addition of diamagnetic components in the system, remaining within the limits of biomedical applications. In vitro free-radical scavenging properties of nanoceria are improved after the coating of nanoparticles with polyethylenimine and conjugation with magnetite nanoparticles. In vivo studies reveal increased antioxidant activity in all organs and fluids collected from mice, which demonstrates the ability of the nanoconjugates to reduce oxidative stress. Conclusion. Nanoconjugates possess magnetic properties, being able to scavenge free radicals, reducing the oxidative stress. The combination of the two properties mentioned above makes them excellent candidates for theranostic applications.

Molecular docking and antioxidant activity of Cleome simplicifolia assisted synthesis of cerium oxide nanoparticles

2020 ◽  
Vol 29 ◽  
pp. 1085-1090
Author(s):  
Ratiram Gomaji Chaudhary ◽  
Prashant B. Chouke ◽  
Rina D. Bagade ◽  
Ajay K. Potbhare ◽  
Kanhaiya M. Dadure
Keyword(s):  
Antioxidant Activity ◽  
Molecular Docking ◽  
Cerium Oxide ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles

Crystal plane effects of nano-CeO2 on its antioxidant activity

RSC Advances ◽  
2014 ◽  
Vol 4 (92) ◽  
pp. 50325-50330 ◽  
Author(s):  
Yan Zhang ◽  
Kebin Zhou ◽  
Yanwu Zhai ◽  
Fei Qin ◽  
Lulu Pan ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Cerium Oxide ◽  
Crystal Plane ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Factors Influencing

Due to the conflicting reports on the antioxidant activity of cerium oxide nanoparticles, much work has been done to explore the factors influencing the antioxidant activity of nano-CeO2.

scholarly journals Oxygen-Vacancy Engineering of Cerium-Oxide Nanoparticles for Antioxidant Activity

ACS Omega ◽  
2019 ◽  
Vol 4 (5) ◽  
pp. 9473-9479 ◽  
Author(s):  
Cindy Gunawan ◽  
Megan S. Lord ◽  
Emma Lovell ◽  
Roong Jien Wong ◽  
Moon Sun Jung ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Oxygen Vacancy ◽  
Cerium Oxide ◽  
Cerium Oxide Nanoparticles ◽  
Oxide Nanoparticles
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