The inhibitory role of intracellular free zinc in the regulation of Arg-1 expression in interleukin-4-induced activation of M2 microglia

Metallomics ◽  
2018 ◽  
Vol 10 (10) ◽  
pp. 1501-1509 ◽  
Author(s):  
Takaaki Aratake ◽  
Youichirou Higashi ◽  
Yusuke Ueba ◽  
Tomoya Hamada ◽  
Takahiro Shimizu ◽  
...  
Keyword(s):  
Interleukin 4 ◽  
Intracellular Zinc ◽  
M2 Polarization ◽  
Inhibitory Role ◽  
M2 Microglia ◽  
Intracellular Free Zinc ◽  
Free Zinc

Intracellular zinc plays an important role in neuroprotective M2-polarization of microglia.

Fasudil-Triggered Phagocytosis of Myelin Debris Promoted Meylin Regeneration via the Activation of TREM2/DAP12 Signaling Pathway in Cuprizone-Induced Mice

2021 ◽  
Author(s):  
Zhi-Bin Ding ◽  
Qing-Xian Han ◽  
Li-Juan Song ◽  
Qing Wang ◽  
Guang-Yuan Han ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Animal Experiments ◽  
Demyelinating Diseases ◽  
Phagocytic Capacity ◽  
Microglial Phagocytosis ◽  
M2 Polarization ◽  
M2 Microglia ◽  
Myelin Debris ◽  
The Central Nervous System

Abstract The inflammation and demyelination of the central nervous system (CNS) are mainly involved in multiple sclerosis (MS), in which the disorder of myelin regeneration leads to continual neurologic impairment. Fasudil, one of the ROCK inhibitors, has been shown protective functions in some models of demyelinating diseases. In this study, Fasudil treatment ameliorated the behavioral performance and myelin loss in CPZ-fed mice. Here, we demonstrated a new role of Fasudil, which triggered microglia to uptake myelin debris in both cell and animal experiments. This increased phagocytosis was associated with the polarization of M2 microglia. Furthermore, we found that Fasudil enhanced the expression of triggering receptor expressed on myeloid cells 2 (TREM2) and DNAX-activating protein of 12 kDa (DAP12), which regulated microglial phagocytosis and M2 polarization. The silence of TREM2 effectively blocked Fasudil-triggered phagocytic capacity, suggesting that Fasudil-triggered phagocytosis depends on TREM2 signaling pathway. Based on these evidences that TREM2 regulates microglial M2 polarization and phagocytosis, future studies targeted Fasudil as a therapy for demyelinating and neurodegenerative diseases are warranted.

scholarly journals Depletion of Endogenous Zinc Stores Induces Oxidative Stress and Cell Death in Human Melanoma Cells

2004 ◽  
Vol 47 (2) ◽  
pp. 91-96 ◽  
Author(s):  
Emil Rudolf ◽  
Miroslav Červinka
Keyword(s):  
Caspase 3 ◽  
Transmembrane Potential ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Nuclear Fragmentation ◽  
Human Melanoma Cells ◽  
Intracellular Free Zinc ◽  
Free Zinc ◽  
Cell Blebbing

The role of intracellular free zinc and its chelation by TPEN (N,N,N’,N’-tetrakis(2–pyridylmethyl)ethylenediamine) was studied in Bowes human melanoma cells. The content of free Zn pools was determined by fluorescent probe Zinquin. Depletion of zinc triggered apoptosis confirmed by cell blebbing, changes in mitochondrial transmembrane potential and GSH levels, caspase-3 activation and nuclear fragmentation. Apoptosis was only partially prevented by cyclosporin A or N-acetylcystein, suggesting various independent but likely interrelated mechanisms participating in this process.

Inhibitory Role of Plasminogen Activator Inhibitor-1 in Arterial Wound Healing and Neointima Formation

Circulation ◽  
1997 ◽  
Vol 96 (9) ◽  
pp. 3180-3191 ◽  
Author(s):  
Peter Carmeliet ◽  
Lieve Moons ◽  
Roger Lijnen ◽  
Stefaan Janssens ◽  
Florea Lupu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Plasminogen Activator ◽  
Plasminogen Activator Inhibitor ◽  
Neointima Formation ◽  
Plasminogen Activator Inhibitor 1 ◽  
Inhibitory Role ◽  
Activator Inhibitor

scholarly journals The inhibitory role of synthesized Nickel oxide nanoparticles against Hep-G2, MCF-7, and HT-29 cell lines: the inhibitory role of NiO NPs against Hep-G2, MCF-7, and HT-29 cell lines

2021 ◽  
Vol 14 (3) ◽  
pp. 443-453
Author(s):  
Mohammad Amin Jadidi Kouhbanani ◽  
Yasin Sadeghipour ◽  
Mina Sarani ◽  
Erfan Sefidgar ◽  
Saba Ilkhani ◽  
...  
Keyword(s):  
Nickel Oxide ◽  
Cell Lines ◽  
Oxide Nanoparticles ◽  
Hep G2 ◽  
Nickel Oxide Nanoparticles ◽  
Inhibitory Role ◽  
Nio Nps ◽  
Ht 29 ◽  
Mcf 7

scholarly journals Correction to: Inactivation of the Wnt/β-catenin signaling pathway underlies inhibitory role of microRNA-129-5p in epithelial–mesenchymal transition and angiogenesis of prostate cancer by targeting ZIC2

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Zhenming Jiang ◽  
Yuxi Zhang ◽  
Xi Chen ◽  
Pingeng Wu ◽  
Dong Chen
Keyword(s):  
Prostate Cancer ◽  
Signaling Pathway ◽  
Epithelial Mesenchymal Transition ◽  
Mesenchymal Transition ◽  
Inhibitory Role

An amendment to this paper has been published and can be accessed via the original article.

The inhibitory role of clioquinol in the fibrillation of hen egg white lysozyme

2021 ◽  
pp. 138830
Author(s):  
Baoliang Ma ◽  
Haohao Wang ◽  
Yujie Liu ◽  
Fang Wu ◽  
Xudong Zhu
Keyword(s):  
Egg White ◽  
Hen Egg White Lysozyme ◽  
Egg White Lysozyme ◽  
Inhibitory Role ◽  
Hen Egg White ◽  
Hen Egg

scholarly journals Entry-inhibitory role of catechins against SARS-CoV-2 and its UK variant

2021 ◽  
pp. 104560
Author(s):  
Susmit Mhatre ◽  
Nitisha Gurav ◽  
Mansi Shah ◽  
Vandana Patravale
Keyword(s):  
Inhibitory Role

Inhibitory role of oleanolic acid and esculetin in HeLa cells involve multiple signaling pathways

Gene ◽  
2021 ◽  
Vol 771 ◽  
pp. 145370
Author(s):  
Prajitha Mohandas Edathara ◽  
Shivakanth Chintalapally ◽  
Venkata Krishna Kanth Makani ◽  
Chitrakshi Pant ◽  
Suresh Yerramsetty ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Oleanolic Acid ◽  
Hela Cells ◽  
Inhibitory Role ◽  
Multiple Signaling

scholarly journals The inhibitory role of 12- and 15-lipoxygenase products on renin release.

Hypertension ◽  
1987 ◽  
Vol 10 (1) ◽  
pp. 61-66 ◽  
Author(s):  
I Antonipillai ◽  
J L Nadler ◽  
E C Robin ◽  
R Horton
Keyword(s):  
Renin Release ◽  
Inhibitory Role ◽  
Lipoxygenase Products
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