Methylselenol release as a cytotoxic tool: a study of the mechanism of the activity achieved by two series of methylselenocarbamate derivatives

Metallomics ◽  
2018 ◽  
Vol 10 (8) ◽  
pp. 1128-1140 ◽  
Author(s):  
María Font ◽  
Beatriz Romano ◽  
Elena González-Peñas ◽  
Carmen Sanmartín ◽  
Daniel Plano ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Relative Reactivity ◽  
Structural Variations ◽  
Nucleophilic Agent ◽  
Overall Stability ◽  
Active Fragments

Cytotoxic activity is related to the progressive release of active fragments, methylselenol and phenols. The structural variations influence the relative reactivity of the target atoms to the nucleophilic agent, as well as the overall stability and the accessibility to the hydrolysis point.

Crystalloid Inclusions in Hepatocyte Mitochondria and Their Similarity to Cytoplasmic Crystalloids

1974 ◽  
Vol 32 ◽  
pp. 198-199
Author(s):  
Odell T. Minick ◽  
Hidejiro Yokoo
Keyword(s):  
Liver Disease ◽  
Alcoholic Liver Disease ◽  
Special Interest ◽  
Structural Variations ◽  
Mitochondrial Alterations ◽  
The Matrix ◽  
Crystalloid Inclusions ◽  
Liver Biopsies

Mitochondrial alterations were studied in 25 liver biopsies from patients with alcoholic liver disease. Of special interest were the morphologic resemblance of certain fine structural variations in mitochondria and crystalloid inclusions. Four types of alterations within mitochondria were found that seemed to relate to cytoplasmic crystalloids.Type 1 alteration consisted of localized groups of cristae, usually oriented in the long direction of the organelle (Fig. 1A). In this plane they appeared serrated at the periphery with blind endings in the matrix. Other sections revealed a system of equally-spaced diagonal lines lengthwise in the mitochondrion with cristae protruding from both ends (Fig. 1B). Profiles of this inclusion were not unlike tangential cuts of a crystalloid structure frequently seen in enlarged mitochondria described below.

Phytochemical characterization and cytotoxic activity of Iranecio elbursensis Bioss.

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
L Shafiee Hanjani ◽  
P Yazdizadeh Shotorbani ◽  
T Asgari ◽  
G Amin ◽  
E Azizi
Keyword(s):  
Cytotoxic Activity

Unusual Cycloartane Saponins with Cytotoxic Activity from Astragalus stereocalyx Bornm.

Planta Medica ◽  
2011 ◽  
Vol 77 (12) ◽  
Author(s):  
FN Yalçın ◽  
S Piacente ◽  
A Perrone ◽  
A Capasso ◽  
H Duman ◽  
...  
Keyword(s):  
Cytotoxic Activity

Screening of Venezuelan medicinal plant extracts for cytostatic and cytotoxic activity against tumour cell lines

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
P Taylor ◽  
M Arsenak ◽  
MJ Abad ◽  
Á Fernández ◽  
R Gonto ◽  
...  
Keyword(s):  
Medicinal Plant ◽  
Cytotoxic Activity ◽  
Cell Lines ◽  
Plant Extracts ◽  
Tumour Cell ◽  
Medicinal Plant Extracts ◽  
Tumour Cell Lines

Cytotoxic activity against tumour cell lines and anti-inflammatory effects of compounds isolated from Xylopia aromatica

Planta Medica ◽  
2013 ◽  
Vol 79 (13) ◽  
Author(s):  
O Estrada ◽  
L González ◽  
M Mijares ◽  
Á Fernández ◽  
M Ruiz ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Cell Lines ◽  
Tumour Cell ◽  
Tumour Cell Lines ◽  
Anti Inflammatory
Sign in / Sign up

Export Citation Format

Share Document