scholarly journals Single-platform ‘multi-omic’ profiling: unified mass spectrometry and computational workflows for integrative proteomics–metabolomics analysis

2018 ◽  
Vol 14 (5) ◽  
pp. 307-319 ◽  
Author(s):  
Benjamin C. Blum ◽  
Fatemeh Mousavi ◽  
Andrew Emili
Keyword(s):  
Mass Spectrometry ◽  
Molecular Basis ◽  
Biological Systems ◽  
Network Models ◽  
Signaling Cascades ◽  
Analysis Tools ◽  
Metabolomics Analysis

Advances in instrumentation and analysis tools are permitting evermore comprehensive interrogation of diverse biomolecules and allowing investigators to move from linear signaling cascades to network models, which more accurately reflect the molecular basis of biological systems and processes.

scholarly journals Unraveling the molecular basis of subunit specificity in P pilus assembly by mass spectrometry

2008 ◽  
Vol 105 (35) ◽  
pp. 12873-12878 ◽  
Author(s):  
R. J. Rose ◽  
D. Verger ◽  
T. Daviter ◽  
H. Remaut ◽  
E. Paci ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Molecular Basis ◽  
Pilus Assembly

Advancements in capturing and mining mass spectrometry data are transforming natural products research

2021 ◽  
Author(s):  
Scott A. Jarmusch ◽  
Justin J. J. van der Hooft ◽  
Pieter C. Dorrestein ◽  
Alan K. Jarmusch
Keyword(s):  
Mass Spectrometry ◽  
Data Mining ◽  
Natural Products ◽  
Data Analysis ◽  
Community Participation ◽  
Mass Spectrometry Data ◽  
Metabolomics Data ◽  
Analysis Tools ◽  
Public Data ◽  
Potential Use

This review covers the current and potential use of mass spectrometry-based metabolomics data mining in natural products. Public data, metadata, databases and data analysis tools are critical. The value and success of data mining rely on community participation.

Fluorescent Probes and Mass Spectrometry-Based Methods to Quantify Thiols in Biological Systems

2021 ◽  
Author(s):  
Lingfei Wang ◽  
Feng Jin ◽  
Xiqian Jiang ◽  
Jianwei Chen ◽  
Meng C Wang ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Fluorescent Probes ◽  
Biological Systems

Real-Time Mass Spectrometry Measurements of Respiration Rates in Biological Systems

2020 ◽  
Author(s):  
Karl K. Weitz ◽  
Montana L. Smith ◽  
Kim K. Hixson ◽  
Eric A. Hill ◽  
Janet K. Jansson ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Real Time ◽  
Biological Systems ◽  
Respiration Rates

scholarly journals Transformative opportunities for single-cell proteomics

2018 ◽  
Author(s):  
Harrison Specht ◽  
Nikolai Slavov
Keyword(s):  
Mass Spectrometry ◽  
Stem Cell ◽  
Cell Differentiation ◽  
Single Cell ◽  
Single Cells ◽  
Biological Systems ◽  
Stem Cell Differentiation ◽  
New Age ◽  
Technological Developments

Many pressing medical challenges - such as diagnosing disease, enhancing directed stem cell differentiation, and classifying cancers - have long been hindered by limitations in our ability to quantify proteins in single cells. Mass-spectrometry (MS) is poised to transcend these limitations by developing powerful methods to routinely quantify thousands of proteins and proteoforms across many thousands of single cells. We outline specific technological developments and ideas that can increase the sensitivity and throughput of single cell MS by orders of magnitude and usher in this new age. These advances will transform medicine and ultimately contribute to understanding biological systems on an entirely new level.

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