scholarly journals Structure–activity relationship of the cinnamamide family of antibiotic potentiators for methicillin-resistant Staphylococcus aureus (MRSA)

MedChemComm ◽  
2018 ◽  
Vol 9 (12) ◽  
pp. 2008-2016
Author(s):  
Enrico Speri ◽  
Jennifer Fishovitz ◽  
Shahriar Mobashery
Keyword(s):  
Staphylococcus Aureus ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Methicillin Resistant ◽  
Structure Activity ◽  
Relationship Of

MIC of oxacillin against S. aureus (MRSA252 strain) reduced from 256 μg mL−1 to 2 μg mL−1.

scholarly journals Chemical Synthesis and Structure-Activity Relationship Study Yield Desotamide a Analogues with Improved Antibacterial Activity

Marine Drugs ◽  
2021 ◽  
Vol 19 (6) ◽  
pp. 303
Author(s):  
Run Xu ◽  
Yongxiang Song ◽  
Jun Li ◽  
Jianhua Ju ◽  
Qinglian Li
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Fold Increase ◽  
Antibacterial Activities ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Gram Positive ◽  
Methicillin Resistant ◽  
Structure Activity ◽  
Relationship Of

Desotamides A, a cyclohexapeptide produced by the deep-sea-derived Streptomyces scopuliridis SCSIO ZJ46, displays notable antibacterial activities against strains of Streptococcus pnuemoniae, Staphylococcus aureus, and methicillin-resistant Staphylococcus epidermidis (MRSE). In this study, to further explore its antibacterial potential and reveal the antibacterial structure-activity relationship of desotamides, 13 cyclopeptides including 10 new synthetic desotamide A analogues and wollamides B/B1/B2 were synthesized and evaluated for their antibacterial activities against a panel of Gram-positive and -negative pathogens. The bioactivity data reveal that residues at position II and VI greatly impact antibacterial activity. The most potent antibacterial analogues are desotamide A4 (13) and A6 (15) where l-allo-Ile at position II was substituted with l-Ile and Gly at position VI was simultaneously replaced by d-Lys or d-Arg; desotamides A4 (13) and A6 (15) showed a 2–4-fold increase of antibacterial activities against a series of Gram-positive pathogens including the prevalent clinical drug-resistant pathogen methicillin-resistant Staphylococcus aureus (MRSA) with MIC values of 8–32 μg/mL compared to the original desotamide A. The enhanced antibacterial activity, broad antibacterial spectrum of desotamides A4 and A6 highlighted their potential as new antibiotic leads for further development.

scholarly journals Antibacterial effect of 3-p-trans-coumaroyl-2-hydroxyquinic acid, a phenolic compound from needles ofCedrus deodara, on cellular functions ofStaphylococcus aureus

RSC Advances ◽  
2018 ◽  
Vol 8 (9) ◽  
pp. 4969-4975 ◽  
Author(s):  
Yanping Wu ◽  
Jinrong Bai ◽  
Xiaoyan Liu ◽  
Lijin Liu ◽  
Kai Zhong ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Phenolic Compound ◽  
Antibacterial Effect ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Ofstaphylococcus Aureus ◽  
Cellular Functions ◽  
Cedrus Deodara ◽  
Structure Activity ◽  
Relationship Of

Structure–activity relationship of 3-p-trans-coumaroyl-2-hydroxyquinic acid, a phenolic compound from needles ofCedrus deodara, againstStaphylococcus aureusand its effect on the cellular functions.

Structure-activity relationship of (-) mammea A/BB derivatives against Leishmania amazonensis

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
MA Brenzan ◽  
CV Nakamura ◽  
BPD Filho ◽  
T Ueda-Nakamura ◽  
MCM Young ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Leishmania Amazonensis ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Of
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