scholarly journals Synthesis and biological evaluation of novel asymmetric naphthalene diimide derivatives as anticancer agents depending on ROS generation

MedChemComm ◽  
2018 ◽  
Vol 9 (8) ◽  
pp. 1377-1385 ◽  
Author(s):  
Xiaojuan Xu ◽  
Senzhen Wang ◽  
Yuan Chang ◽  
Chaochao Ge ◽  
Xinna Li ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Biological Evaluation ◽  
Hepatoma Cells ◽  
Ros Generation ◽  
Naphthalene Diimide ◽  
Induced Apoptosis ◽  
Synthesis And Biological Evaluation

Compound 3c induced apoptosis and autophagy and inhibited the migration of hepatoma cells depending on ROS generation.

Synthesis and Biological Evaluation of 1,3,4-Thiadiazole Linked Phthalimide Derivatives as Anticancer Agents

2017 ◽  
Vol 14 (10) ◽  
Author(s):  
Zahra Rezaei ◽  
Setareh Moghimi ◽  
Rezvan Javaheri ◽  
Mehdi Asadi ◽  
Mohammad Mahdavi ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

Hybridized Quinoline Derivatives as Anticancer Agents: Design, Synthesis, Biological Evaluation and Molecular Docking

2019 ◽  
Vol 19 (4) ◽  
pp. 439-452 ◽  
Author(s):  
Mohamed R. Selim ◽  
Medhat A. Zahran ◽  
Amany Belal ◽  
Moustafa S. Abusaif ◽  
Said A. Shedid ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Anticancer Agents ◽  
Caspase 3 ◽  
Biological Evaluation ◽  
Tubulin Polymerization ◽  
Design Synthesis ◽  
Chemical Structures ◽  
M Phase ◽  
Induced Apoptosis ◽  
Derivatives Of

Objective: Conjugating quinolones with different bioactive pharmacophores to obtain potent anticancer active agents. Methods: Fused pyrazolopyrimidoquinolines 3a-d, Schiff bases 5, 6a-e, two hybridized systems: pyrazolochromenquinoline 7 and pyrazolothiazolidinquinoline 8, different substituted thiazoloquinolines 13-15 and thiazolo[3,2-a]pyridine derivatives 16a-c were synthesized. Their chemical structures were characterized through spectral and elemental analysis, cytotoxic activity on five cancer cell lines, caspase-3 activation, tubulin polymerization inhibition and cell cycle analysis were evaluated. Results: Four compounds 3b, 3d, 8 and 13 showed potent activity than doxorubicin on HCT116 and three compounds 3b, 3d and 8 on HEPG2. These promising derivatives showed increase in the level of caspase-3. The trifloromethylphenyl derivatives of pyrazolopyrimidoquinolines 3b and 3d showed considerable tubulin polymerization inhibitory activity. Both compounds arrested cell cycle at G2/M phase and induced apoptosis. Conclusion: Compounds 3b and 3d can be considered as promising anticancer active agents with 70% of colchicine activity on tubulin polymerization inhibition and represent hopeful leads that deserve further investigation and optimization.

Design, Synthesis and Biological Evaluation of Tetrahydrodibenzo[b,g][1,8]napthyridinones as Potential Anticancer Agents and Novel Aurora Kinases Inhibitors

2021 ◽  
Vol 6 (14) ◽  
pp. 3444-3452
Author(s):  
Asha V. Chate ◽  
Pramod A. Tagad ◽  
Giribala M. Bondle ◽  
Aniket P. Sarkate ◽  
Shailee V. Tiwari ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Aurora Kinases ◽  
Synthesis And Biological Evaluation

scholarly journals Molecular modeling study, synthesis and biological evaluation of combretastatin A-4 analogues as anticancer agents and tubulin inhibitors

MedChemComm ◽  
2018 ◽  
Vol 9 (2) ◽  
pp. 316-327 ◽  
Author(s):  
Yang Ping Quan ◽  
Li Ping Cheng ◽  
Tian Chi Wang ◽  
Wan Pang ◽  
Fan Hong Wu ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Anticancer Agents ◽  
Hepg2 Cells ◽  
Binding Mode ◽  
Biological Evaluation ◽  
Tubulin Inhibitors ◽  
Molecular Modeling Study ◽  
Synthesis And Biological Evaluation ◽  
Modeling Study

Compound 13a, more effective than CA-4 against HepG2 cells and tubulin, and the proposed binding mode for 13a.

Synthesis and biological evaluation of novel withangulatin A derivatives as potential anticancer agents

2021 ◽  
Vol 108 ◽  
pp. 104690
Author(s):  
Wu-Xi Zhou ◽  
Chen Chen ◽  
Xiao-Qin Liu ◽  
Ying Li ◽  
Ling-Yi Kong ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Biological Evaluation ◽  
Synthesis And Biological Evaluation

Design, Synthesis, and Biological Evaluation of (E)-Styrylbenzylsulfones as Novel Anticancer Agents

2008 ◽  
Vol 51 (1) ◽  
pp. 86-100 ◽  
Author(s):  
M. V. Ramana Reddy ◽  
Muralidhar R. Mallireddigari ◽  
Stephen C. Cosenza ◽  
Venkat R. Pallela ◽  
Nabisa M. Iqbal ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

Synthesis and biological evaluation of novel aniline-derived asiatic acid derivatives as potential anticancer agents

2014 ◽  
Vol 86 ◽  
pp. 175-188 ◽  
Author(s):  
Jian-Fei Li ◽  
Ri-Zhen Huang ◽  
Gui-Yang Yao ◽  
Man-Yi Ye ◽  
Heng-Shan Wang ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Biological Evaluation ◽  
Asiatic Acid ◽  
Synthesis And Biological Evaluation
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