scholarly journals Design, synthesis and bioactivity investigation of tetrandrine derivatives as potential anti-cancer agents

MedChemComm ◽  
2018 ◽  
Vol 9 (7) ◽  
pp. 1131-1141 ◽  
Author(s):  
Junrong Song ◽  
Junjie Lan ◽  
Chao Chen ◽  
Shengcao Hu ◽  
Jialei Song ◽  
...  
Keyword(s):  
Growth Inhibition ◽  
Design Synthesis ◽  
Anti Cancer

Twenty-four 14-sulfonamide–tetrandrine derivatives were synthesized. Compound23exhibited growth inhibition of MDA-MB-231 cells with an IC50value of 1.18 ± 0.14 μM.

Design, synthesis, anti-cancer evaluation and binding mode studies of benzimidazole/benzoxazole linked β-carboline derivatives

2021 ◽  
Vol 1226 ◽  
pp. 129351
Author(s):  
Reddymasu Sireesha ◽  
Reddymasu Sreenivasulu ◽  
Choragudi Chandrasekhar ◽  
Surender Singh Jadav ◽  
Y. Pavani ◽  
...  
Keyword(s):  
Binding Mode ◽  
Design Synthesis ◽  
Anti Cancer

scholarly journals Discovery of new 3-methylquinoxalines as potential anti-cancer agents and apoptosis inducers targeting VEGFR-2: design, synthesis, and in silico studies

2021 ◽  
Vol 36 (1) ◽  
pp. 1732-1750
Author(s):  
Mohammed M. Alanazi ◽  
Elwan Alaa ◽  
Nawaf A. Alsaif ◽  
Ahmad J. Obaidullah ◽  
Hamad M. Alkahtani ◽  
...  
Keyword(s):  
In Silico ◽  
Design Synthesis ◽  
In Silico Studies ◽  
Anti Cancer

SYNTHESIS AND ANTICANCER ACTIVITY EVALUATION OF SOME SCHIFF BASES OF 1, 3, 4-OXADIAZOLE

INDIAN DRUGS ◽  
2019 ◽  
Vol 56 (03) ◽  
pp. 12-17
Author(s):  
Manpreet Kaur ◽  
S. Singh ◽  
Keyword(s):  
Schiff Base ◽  
Growth Inhibition ◽  
Anticancer Activity ◽  
Maximum Growth ◽  
Schiff Base Derivatives ◽  
Control Growth ◽  
Anti Cancer ◽  
Oxadiazole Derivatives ◽  
Cancer Activity ◽  
Mcf 7

A new series of 2,5-disubstituted-1,3,4-oxadiazole derivatives has been synthesized with the help of different aromatic benzaldehydes and final compounds were characterized by FTIR and 1H NMR. 2,5- disubstituted-1,3,4-oxadiazole derivatives were synthesized by the reaction of Schiff base derivatives with 2,5-disubstituted-1,3,4-oxadiazoles. All the synthesized compounds were screened for their anticancer activity. These compounds were evaluated for their anticancer activity against various cancer cell lines. Five of the compounds possessed good to moderate anti-cancer activity. Three of the synthesized compounds i.e. 6a, 6f and 6g were found to possess maximum growth inhibition. The order for the % control growth inhibition of MCF-7 was found to be 6a>6f>6g>5b>6h, as shown in Table II-VI.

Design, Synthesis and Anti-Cancer Activities of Benzyl Analogues of Garlic-Derived Diallyl Disulfide (DADS) and the Corresponding Diselenides

2017 ◽  
Vol 2 (24) ◽  
pp. 7399-7406 ◽  
Author(s):  
Debojit Bhattacherjee ◽  
Chitra Basu ◽  
Queen Bhardwaj ◽  
Sourav Mal ◽  
Subhajit Sahu ◽  
...  
Keyword(s):  
Diallyl Disulfide ◽  
Design Synthesis ◽  
Anti Cancer

scholarly journals Mitochondria-targeting fluorescent molecules for high efficiency cancer growth inhibition and imaging

2019 ◽  
Vol 10 (34) ◽  
pp. 7946-7951 ◽  
Author(s):  
Hao Chen ◽  
Jing Wang ◽  
Xin Feng ◽  
Mark Zhu ◽  
Simon Hoffmann ◽  
...  
Keyword(s):  
Growth Inhibition ◽  
High Efficiency ◽  
Clinical Translation ◽  
Cancer Growth ◽  
Lipophilic Cations ◽  
Anti Cancer ◽  
Low Toxicity ◽  
Fluorescent Molecules ◽  
Mitochondria Targeting

5BMF is a new fluorescent mitochondria-accumulating delocalized lipophilic cations [DLC] that boasts significantly increased anti-cancer effects and low toxicity in comparison to previous DLCs, addressing current hurdles in DLC clinical translation.

Design, synthesis, and biological activity evaluation of (-)-6-O-desmethylantofine analogues as potent anti-cancer agents

2019 ◽  
Vol 27 (14) ◽  
pp. 3070-3081 ◽  
Author(s):  
Guifang Han ◽  
Lihua Qing ◽  
Meng Wu ◽  
Yuxiang Wang ◽  
Yuxiu Liu ◽  
...  
Keyword(s):  
Biological Activity ◽  
Design Synthesis ◽  
Activity Evaluation ◽  
Anti Cancer

Design, synthesis, molecular docking, and biological evaluation of N-methyl-3-nitro-4-(nitromethyl)-4H-chromen-2-amine derivatives as potential anti-cancer agents

2013 ◽  
Vol 23 (2) ◽  
pp. 642-659 ◽  
Author(s):  
A. Parthiban ◽  
J. Muthukumaran ◽  
A. Moushumi Priya ◽  
S. Jayachandran ◽  
R. Krishna ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Anti Cancer
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