Disposable silicon-glass microfluidic devices: precise, robust and cheap

Lab on a Chip ◽  
2018 ◽  
Vol 18 (24) ◽  
pp. 3872-3880 ◽  
Author(s):  
ZhenBang Qi ◽  
Lining Xu ◽  
Yi Xu ◽  
Junjie Zhong ◽  
Ali Abedini ◽  
...  

We developed a method for reducing the cost of Si-glass microfluidic chips while maintaining the precision and robustness unique to Si-glass system.

2021 ◽  
Vol 25 (8) ◽  
Author(s):  
Yanwei Wang ◽  
Michael Seidel

AbstractFabrication of 3D microfluidic devices is normally quite expensive and tedious. A strategy was established to rapidly and effectively produce multilayer 3D microfluidic chips which are made of two layers of poly(methyl methacrylate) (PMMA) sheets and three layers of double-sided pressure sensitive adhesive (PSA) tapes. The channel structures were cut in each layer by cutting plotter before assembly. The structured channels were covered by a PMMA sheet on top and a PMMA carrier which contained threads to connect with tubing. A large variety of PMMA slides and PSA tapes can easily be designed and cut with the help of a cutting plotter. The microfluidic chip was manually assembled by a simple lamination process.The complete fabrication process from device design concept to working device can be completed in minutes without the need of expensive equipment such as laser, thermal lamination, and cleanroom. This rapid frabrication method was applied for design of a 3D hydrodynamic focusing device for synthesis of gold nanoparticles (AuNPs) as proof-of-concept. The fouling of AuNPs was prevented by means of a sheath flow. Different parameters such as flow rate and concentration of reagents were controlled to achieve AuNPs of various sizes. The sheet-based fabrication method offers a possibility to create complex microfluidic devices in a rapid, cheap and easy way.


Author(s):  
Shuo Wang ◽  
Peter Shankles ◽  
Scott Retterer ◽  
Yong Tae Kang ◽  
Chang Kyoung Choi

Abstract Opto-microfluidic methods have advantages for manufacturing complex shapes or structures of micro particles/hydrogels. Most of these microfluidic devices are made of polydimethylsiloxane (PDMS) by soft lithography because of its flexibility of designing and manufacturing. However, PDMS scatters ultraviolet (UV) light, which polymerizes the photocrosslinkable materials at undesirable locations and clogs the microfluidic devices. A fluorescent dye has previously been employed to absorb the scattered UV light and shift its wavelength to effectively solve this issue. However, this method is limited due to the cost of the materials (tens of dollars per microchip), the time consumed on synthesizing the fluorescent material and verifying its quality (two to three days). More importantly, significant expertise on material synthesis and characterization is required for users of the opto-microfluidic technique. The cost of preliminary testing on multiple iterations of different microfluidic chip designs would also be excessive. Alternatively, with a delicate microchannel design, we simply inserted aluminum foil strips (AFS) inside the PDMS device to block the scattered UV light. By using this method, the UV light was limited to the exposure region so that the opto-microfluidic device could consistently generate microgels longer than 6 h. This is a nearly cost- and labor-free method to solve this issue.


2021 ◽  
Author(s):  
Heba Mansour ◽  
Ahmed M.R. Fath El-Bab ◽  
Emad A. Soliman ◽  
Ahmed L. Abdel-Mawgood

Abstract Microfluidic devices are a rising technology to automatize chemical and biological operations. In this context, laser ablation has significant potential for polymer-based microfluidic platforms' fast and economical manufacturing. Nevertheless, the manufacturing of epoxy-based microfluidic chips is considered highly cost full due to demand for cleanroom facilities that utilize expensive equipment and lengthy processes. Therefore, this study targeted investigating the feasibility of epoxy resins to be fabricated as a lab-on-chip using carbon dioxide laser ablation. The chemical structural properties and thermal stability of the plain epoxy resins were characterized by Fourier transform infrared spectral analysis (FT-IR) and thermogravimetric analysis (TGA). Moreover, a specific migration test was performed to quantify potential migrants by gas chromatography coupled to mass spectrometry (GC-MS) to prove that the cured epoxy resin would not release unreacted monomers to the biological solution test, which caused inhibition of the sensitive biological reactions. By investigating the impact of this process on microchannels' dimensions and quality, a laser technique using CO2 laser was used in vector mode to engrave into a transparent epoxy resin chip. The resulting microchannels were characterized using 3D Laser microscopy. The outcomes of this study showed considerable potential for laser ablation in machining the epoxy-based chips, whereas the microchannels were produced with minor bulges' height (0.027 µm) with no clogging. Moreover, a reasonable depth of 99.31 µm with roughness (Ra) of 14.52 µm was obtained at a laser speed of 5 mm/s and laser power of 1.8 W. This process can produce epoxy resin-based microfluidic chips without the need for cleanroom facilities that require expensive equipment and lengthy process.


The Analyst ◽  
2015 ◽  
Vol 140 (23) ◽  
pp. 7896-7901 ◽  
Author(s):  
Yanlong Xing ◽  
Andreas Wyss ◽  
Norbert Esser ◽  
Petra S. Dittrich

Label-free biosensors based on in situ formed and functionalized TTF–Au wires were developed using an integrated microfluidic system.


2019 ◽  
pp. 125-144
Author(s):  
Peter Sloman

The ‘rediscovery of poverty’ prompted a wide-ranging debate over how the British government could best support low-income families. One radical response came from Edward Heath’s Conservative government, which published plans to replace the whole system of personal tax allowances with refundable tax credits—the closest any British government has come to introducing a Universal Basic Income. This chapter examines the origins of the Tax Credit Scheme in 1971–2, which was devised by special adviser Arthur Cockfield in response to the rising cost of tax administration and the difficulty of establishing a selective Negative Income Tax in Britain. As the plans took shape, however, the cost of introducing the reforms on a no-losers basis became a source of growing concern within government. Indeed, Treasury officials were relieved when Labour’s victory in the February 1974 election made it possible to jettison the scheme and focus on simplifying and computerizing the PAYE system.


Nanoscale ◽  
2020 ◽  
Vol 12 (16) ◽  
pp. 8801-8808 ◽  
Author(s):  
Liqiang Zhang ◽  
Hang Lin ◽  
Congyong Wang ◽  
Wei-Ren Liu ◽  
Shuxing Li ◽  
...  

Herein, it is proposed a brand-new solid-state Pb2+-sensing strategy based on mechanically-driven glass crystallization in a Pb2+-responsive borate glass system.


Nanoscale ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 189-194 ◽  
Author(s):  
Michael Saccone ◽  
Kevin Hofhuis ◽  
David Bracher ◽  
Armin Kleibert ◽  
Sebastiaan van Dijken ◽  
...  

Tree like interaction structures increase effective dimension in this significant step towards the first ever artificial spin glass system.


CrystEngComm ◽  
2015 ◽  
Vol 17 (11) ◽  
pp. 2327-2335 ◽  
Author(s):  
P. W. Jaschin ◽  
K. B. R. Varma

Dendritic growth of trigonal and square bipyramidal structures of LiTaO3 nanocrystallites, of 19–30 nm size, was observed when 1.5Li2O–2B2O3–0.5Ta2O5 glasses were subjected to controlled heat treatment between 530 °C and 560 °C/3 h.


Author(s):  
Mark F. Grady

Tort law is part of the common law that originated in England after the Norman Conquest and spread throughout the world, including to the United States. It is judge-made law that allows people who have been injured by others to sue those who harmed them and collect damages in proper cases. Since its early origins, tort law has evolved considerably and has become a full-fledged “grown order,” like the economy, and can best be understood by positive theory, also like the economy. Economic theories of tort have developed since the early 1970s, and they too have evolved over time. Their objective is to generate fresh insight about the purposes and the workings of the tort system. The basic thesis of the economic theory is that tort law creates incentives for people to minimize social cost, which is comprised of the harm produced by torts and the cost of the precautions necessary to prevent torts. This thesis, intentionally simple, generates many fresh insights about the workings and effects of the tort system and even about the actual legal rules that judges have developed. In an evolved grown order, legal rules are far less concrete than most people would expect though often very clear in application. Beginning also in the 1970s, legal philosophers have objected to the economic theory of tort and have devised philosophical theories that compete. The competition, moreover, has been productive because it has spurred both sides to revise and improve their theories and to seek better to understand the law. Tort law is diverse, applicable to many different activities and situations, so developing a positive theory about it is both challenging and rewarding.


RSC Advances ◽  
2018 ◽  
Vol 8 (66) ◽  
pp. 37693-37699 ◽  
Author(s):  
Dong-Heon Ha ◽  
Dong-Hyeon Ko ◽  
Jin-oh Kim ◽  
Do Jin Im ◽  
Byoung Soo Kim ◽  
...  

Rapid on-demand sacrificial printing techniques using suitable combinations of resin and sacrificial materials would be desirable to fabricate versatile and functional microfluidic devices with complex designs and chemical resistance.


Sign in / Sign up

Export Citation Format

Share Document