Single stream inertial focusing in low aspect-ratio triangular microchannels

Lab on a Chip ◽  
2019 ◽  
Vol 19 (1) ◽  
pp. 147-157 ◽  
Author(s):  
Prithviraj Mukherjee ◽  
Xiao Wang ◽  
Jian Zhou ◽  
Ian Papautsky

We use inertial microfluidics to demonstrate single-stream 3D focusing of particles in triangular microchannels for cytometry applications.

2009 ◽  
Vol 11 (7) ◽  
pp. 075025 ◽  
Author(s):  
Aman Russom ◽  
Amit K Gupta ◽  
Sunitha Nagrath ◽  
Dino Di Carlo ◽  
Jon F Edd ◽  
...  

Micromachines ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 81
Author(s):  
Shaofei Shen ◽  
Mengqi Gao ◽  
Fangjuan Zhang ◽  
Yanbing Niu

The field of inertial microfluidics has been significantly advanced in terms of application to fluid manipulation for biological analysis, materials synthesis, and chemical process control. Because of their superior benefits such as high-throughput, simplicity, and accurate manipulation, inertial microfluidics designs incorporating channel geometries generating Dean vortexes and helical vortexes have been studied extensively. However, existing technologies have not been studied by designing low-aspect-ratio microchannels to produce multi-vortexes. In this study, an inertial microfluidic device was developed, allowing the generation and regulation of the Dean vortex and helical vortex through the introduction of micro-obstacles in a semicircular microchannel with ultra-low aspect ratio. Multi-vortex formations in the vertical and horizontal planes of four dimension-confined curved channels were analyzed at different flow rates. Moreover, the regulation mechanisms of the multi-vortex were studied systematically by altering the micro-obstacle length and channel height. Through numerical simulation, the regulation of dimensional confinement in the microchannel is verified to induce the Dean vortex and helical vortex with different magnitudes and distributions. The results provide insights into the geometry-induced secondary flow mechanism, which can inspire simple and easily built planar 2D microchannel systems with low-aspect-ratio design with application in fluid manipulations for chemical engineering and bioengineering.


Author(s):  
Todd P. Lagus ◽  
Jon F. Edd

Inertial focusing and ordering in microchannel flows refers to the tendency of finite-sized particles to migrate across streamlines and to form linear, equally spaced trains in the direction of flow. This study utilizes a motorized microscope stage moving along the length of a low aspect ratio microchannel at up to 10 cm/s and provides a Lagrangian view of particles to obtain more complete time dependent trajectory and rotation histories from the channel inlet to outlet. We observe monodisperse particle dynamics, rotations, and interactions over time scales significantly longer (exceeding a 30-fold increase) than static reference frames. The results present new insight into particle interactions which show quasi-steady state equilibrium spacing which oscillates at a constant frequency at a fixed flow rate, which is different from the damped oscillatory interactions suggested in the literature. The average spacing shows little dependence on flow rate, but the oscillation frequency is dependent both on flow rate and particle size.


2012 ◽  
Vol 132 (7) ◽  
pp. 567-573
Author(s):  
Hitoshi Tanaka ◽  
Shota Omi ◽  
Jun Katsuma ◽  
Yurie Yamamoto ◽  
Masaki Uchida ◽  
...  

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