scholarly journals A microfluidic platform for lifelong high-resolution and high throughput imaging of subtle aging phenotypes in C. elegans

Lab on a Chip ◽  
2018 ◽  
Vol 18 (20) ◽  
pp. 3090-3100 ◽  
Author(s):  
Sahand Saberi-Bosari ◽  
Javier Huayta ◽  
Adriana San-Miguel
Keyword(s):  
High Resolution ◽  
High Throughput ◽  
Structure And Function ◽  
Neuronal Structure ◽  
Microfluidic Platform ◽  
C Elegans ◽  
And Function ◽  
High Throughput Imaging

Aging produces a number of changes in the neuronal structure and function throughout a variety of organisms.

scholarly journals HPC and Grid Computing for Integrative Biomedical Research

2009 ◽  
Vol 23 (3) ◽  
pp. 252-264 ◽  
Author(s):  
Tahsin Kurc ◽  
Shannon Hastings ◽  
Vijay Kumar ◽  
Stephen Langella ◽  
Ashish Sharma ◽  
...  
Keyword(s):  
High Resolution ◽  
High Throughput ◽  
Biomedical Research ◽  
High Performance ◽  
Structure And Function ◽  
Research Projects ◽  
Data Types ◽  
And Function ◽  
Performance Computing ◽  
Research Pattern

Integrative biomedical research projects query, analyze, and integrate many different data types and make use of datasets obtained from measurements or simulations of structure and function at multiple biological scales. With the increasing availability of high-throughput and high-resolution instruments, the integrative biomedical research imposes many challenging requirements on software middleware systems. In this paper, we look at some of these requirements using example research pattern templates. We then discuss how middleware systems, which incorporate Grid and high-performance computing, could be employed to address the requirements.

Crystal Structures of Fragments D and Double-D from Fibrinogen and Fibrin

1999 ◽  
Vol 82 (08) ◽  
pp. 271-276 ◽  
Author(s):  
Glen Spraggon ◽  
Stephen Everse ◽  
Russell Doolittle
Keyword(s):  
Electron Microscopy ◽  
High Resolution ◽  
Crystal Structures ◽  
Structure And Function ◽  
X Ray ◽  
Long Period ◽  
And Function

IntroductionAfter a long period of anticipation,1 the last two years have witnessed the first high-resolution x-ray structures of fragments from fibrinogen and fibrin.2-7 The results confirmed many aspects of fibrinogen structure and function that had previously been inferred from electron microscopy and biochemistry and revealed some unexpected features. Several matters have remained stubbornly unsettled, however, and much more work remains to be done. Here, we review several of the most significant findings that have accompanied the new x-ray structures and discuss some of the problems of the fibrinogen-fibrin conversion that remain unresolved. * Abbreviations: GPR—Gly-Pro-Arg-derivatives; GPRPam—Gly-Pro-Arg-Pro-amide; GHRPam—Gly-His-Arg-Pro-amide

Akt-mTOR hypoactivity in bipolar disorder gives rise to cognitive impairments associated with altered neuronal structure and function

Neuron ◽  
2021 ◽  
Author(s):  
Amanda M. Vanderplow ◽  
Andrew L. Eagle ◽  
Bailey A. Kermath ◽  
Kathryn J. Bjornson ◽  
Alfred J. Robison ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Cognitive Impairments ◽  
Structure And Function ◽  
Neuronal Structure ◽  
And Function

scholarly journals Detection of Small-Molecule Modulators of Actin-Myosin Structure and Function using High-Throughput Time-Resolved FRET

2017 ◽  
Vol 112 (3) ◽  
pp. 237a
Author(s):  
Piyali Guhathakurta ◽  
Ewa Prochniewicz ◽  
Kurt C. Peterson ◽  
Benjamin D. Grant ◽  
Gregory D. Gillispie ◽  
...  
Keyword(s):  
Small Molecule ◽  
High Throughput ◽  
Structure And Function ◽  
Throughput Time ◽  
Time Resolved ◽  
Small Molecule Modulators ◽  
And Function

scholarly journals Implementation of High-Throughput Sequencing (HTS) in Aptamer Selection Technology

2020 ◽  
Vol 21 (22) ◽  
pp. 8774
Author(s):  
Natalia Komarova ◽  
Daria Barkova ◽  
Alexander Kuznetsov
Keyword(s):  
Nucleic Acid ◽  
High Throughput ◽  
High Throughput Sequencing ◽  
Combinatorial Libraries ◽  
Structure And Function ◽  
Huge Number ◽  
Systematic Evolution ◽  
And Function ◽  
Exponential Enrichment

Aptamers are nucleic acid ligands that bind specifically to a target of interest. Aptamers have gained in popularity due to their high potential for different applications in analysis, diagnostics, and therapeutics. The procedure called systematic evolution of ligands by exponential enrichment (SELEX) is used for aptamer isolation from large nucleic acid combinatorial libraries. The huge number of unique sequences implemented in the in vitro evolution in the SELEX process imposes the necessity of performing extensive sequencing of the selected nucleic acid pools. High-throughput sequencing (HTS) meets this demand of SELEX. Analysis of the data obtained from sequencing of the libraries produced during and after aptamer isolation provides an informative basis for precise aptamer identification and for examining the structure and function of nucleic acid ligands. This review discusses the technical aspects and the potential of the integration of HTS with SELEX.

A high-resolution view of NK-cell receptors: structure and function

2000 ◽  
Vol 21 (9) ◽  
pp. 428-431 ◽  
Author(s):  
Marco Colonna ◽  
Alessandro Moretta ◽  
Frédéric Vély ◽  
Eric Vivier
Keyword(s):  
High Resolution ◽  
Nk Cell ◽  
Structure And Function ◽  
Cell Receptors ◽  
Nk Cell Receptors ◽  
And Function
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