scholarly journals Micro/nano acoustofluidics: materials, phenomena, design, devices, and applications

Lab on a Chip ◽  
2018 ◽  
Vol 18 (14) ◽  
pp. 1952-1996 ◽  
Author(s):  
William Connacher ◽  
Naiqing Zhang ◽  
An Huang ◽  
Jiyang Mei ◽  
Shuai Zhang ◽  
...  
Keyword(s):  
Lab On A Chip ◽  
Particle Manipulation ◽  
Small Scales ◽  
Acoustic Actuation ◽  
On Chip

Acoustic actuation of fluids at small scales may finally enable a comprehensive lab-on-a-chip revolution in microfluidics, overcoming long-standing difficulties in fluid and particle manipulation on-chip.

scholarly journals 3D printed microfluidic lab-on-a-chip device for fiber-based dual beam optical manipulation

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Haoran Wang ◽  
Anton Enders ◽  
John-Alexander Preuss ◽  
Janina Bahnemann ◽  
Alexander Heisterkamp ◽  
...  
Keyword(s):  
Optical Fibers ◽  
Single Cells ◽  
Lab On A Chip ◽  
Cost Effective ◽  
Optical Manipulation ◽  
Hydrodynamic Focusing ◽  
Trapping Region ◽  
Dual Beam ◽  
3D Printed ◽  
On Chip

Abstract3D printing of microfluidic lab-on-a-chip devices enables rapid prototyping of robust and complex structures. In this work, we designed and fabricated a 3D printed lab-on-a-chip device for fiber-based dual beam optical manipulation. The final 3D printed chip offers three key features, such as (1) an optimized fiber channel design for precise alignment of optical fibers, (2) an optically clear window to visualize the trapping region, and (3) a sample channel which facilitates hydrodynamic focusing of samples. A square zig–zag structure incorporated in the sample channel increases the number of particles at the trapping site and focuses the cells and particles during experiments when operating the chip at low Reynolds number. To evaluate the performance of the device for optical manipulation, we implemented on-chip, fiber-based optical trapping of different-sized microscopic particles and performed trap stiffness measurements. In addition, optical stretching of MCF-7 cells was successfully accomplished for the purpose of studying the effects of a cytochalasin metabolite, pyrichalasin H, on cell elasticity. We observed distinct changes in the deformability of single cells treated with pyrichalasin H compared to untreated cells. These results demonstrate that 3D printed microfluidic lab-on-a-chip devices offer a cost-effective and customizable platform for applications in optical manipulation.

On-Chip Platinum Micro-Heater with Platinum Temperature Sensor for a Fully Integrated Disposable PCR Module

2010 ◽  
Vol 93-94 ◽  
pp. 129-132 ◽  
Author(s):  
W. Sripumkhai ◽  
A. Lekwichai ◽  
Win Bunjongpru ◽  
S. Porntheeraphat ◽  
B. Tunhoo ◽  
...  
Keyword(s):  
Thermal Cycling ◽  
Temperature Sensor ◽  
Lab On A Chip ◽  
Conventional Pcr ◽  
Fully Integrated ◽  
On Chip

The on-chip platinum micro-heater prototypes for thermal cycling equipped with platinum temperature sensor are fabricated. The device has been designed, fabricated and characterized to explore the feasibility of the micro-heater for a fully integrated disposable lab-on-a-chip with the PCR module. The on-chip micro-heater demonstrates that the temperature transitions are shorter by comparison with the conventional PCR temperature routines.

scholarly journals Recent Advances in Continuous-Flow Particle Manipulations Using Magnetic Fluids

Micromachines ◽  
2019 ◽  
Vol 10 (11) ◽  
pp. 744 ◽  
Author(s):  
Xiangchun Xuan
Keyword(s):  
Continuous Flow ◽  
Lab On A Chip ◽  
Microfluidic Devices ◽  
Magnetic Fluids ◽  
Label Free ◽  
Particle Manipulation ◽  
The Past ◽  
Recent Advances ◽  
Medium Exchange ◽  
Flow Particle

Magnetic field-induced particle manipulation is simple and economic as compared to other techniques (e.g., electric, acoustic, and optical) for lab-on-a-chip applications. However, traditional magnetic controls require the particles to be manipulated being magnetizable, which renders it necessary to magnetically label particles that are almost exclusively diamagnetic in nature. In the past decade, magnetic fluids including paramagnetic solutions and ferrofluids have been increasingly used in microfluidic devices to implement label-free manipulations of various types of particles (both synthetic and biological). We review herein the recent advances in this field with focus upon the continuous-flow particle manipulations. Specifically, we review the reported studies on the negative magnetophoresis-induced deflection, focusing, enrichment, separation, and medium exchange of diamagnetic particles in the continuous flow of magnetic fluids through microchannels.

scholarly journals On-Chip Magnetic Platform for Single-Particle Manipulation with Integrated Electrical Feedback

Small ◽  
2015 ◽  
Vol 12 (7) ◽  
pp. 921-929 ◽  
Author(s):  
Marco Monticelli ◽  
Andrea Torti ◽  
Matteo Cantoni ◽  
Daniela Petti ◽  
Edoardo Albisetti ◽  
...  
Keyword(s):  
Single Particle ◽  
Particle Manipulation ◽  
On Chip

Micro and Nano Particle Manipulation Using Optically Modulated Electrokinetic Flows

2009 ◽  
Author(s):  
Stuart J. Williams ◽  
Aloke Kumar ◽  
Steven T. Wereley
Keyword(s):  
Surface Modification ◽  
Parallel Plate ◽  
Near Infrared ◽  
Lab On A Chip ◽  
Nano Particle ◽  
Particle Manipulation ◽  
Physical Mechanisms ◽  
Particle Sorting ◽  
Electrokinetic Flows ◽  
Optically Induced

Recently, we have demonstrated an optically induced AC electrokinetic technique that rapidly, continuously and selectively concentrates colloids on an electrode surface [1–3]. This is demonstrated with a highly focused near-infrared (1,064 nm) laser beam applied to parallel plate electrodes separated by 50 μm without any additional surface modification or patterning of the electrodes. This dynamic optically-induced technique can be applied towards a variety of lab-on-a-chip applications. This paper will explain its physical mechanisms and showcase recent results regarding its particle sorting capabilities. This dynamic, optically induced fluid and particle manipulation technique could be used for a variety of lab-on-a-chip applications.

scholarly journals Miniaturization of fluorescence sensing in optofluidic devices

2020 ◽  
Vol 24 (9) ◽  
Author(s):  
Daniel Măriuţa ◽  
Stéphane Colin ◽  
Christine Barrot-Lattes ◽  
Stéphane Le Calvé ◽  
Jan G. Korvink ◽  
...  
Keyword(s):  
Lab On A Chip ◽  
Time Data ◽  
Fluorescence Sensing ◽  
Successful Development ◽  
Total Analysis System ◽  
Total Analysis ◽  
Integration Strategies ◽  
Analysis System ◽  
On Chip ◽  
Industrial Sensing

Abstract Successful development of a micro-total-analysis system (µTAS, lab-on-a-chip) is strictly related to the degree of miniaturization, integration, autonomy, sensitivity, selectivity, and repeatability of its detector. Fluorescence sensing is an optical detection method used for a large variety of biological and chemical assays, and its full integration within lab-on-a-chip devices remains a challenge. Important achievements were reported during the last few years, including improvements of previously reported methodologies, as well as new integration strategies. However, a universal paradigm remains elusive. This review considers achievements in the field of fluorescence sensing miniaturization, starting from off-chip approaches, representing miniaturized versions of their lab counter-parts, continuing gradually with strategies that aim to fully integrate fluorescence detection on-chip, and reporting the results around integration strategies based on optical-fiber-based designs, optical layer integrated designs, CMOS-based fluorescence sensing, and organic electronics. Further successful development in this field would enable the implementation of sensing networks in specific environments that, when coupled to Internet-of-Things (IoT) and artificial intelligence (AI), could provide real-time data collection and, therefore, revolutionize fields like health, environmental, and industrial sensing.

Optically Induced Electrokinetic Trapping and Sorting of Colloids

2010 ◽  
Author(s):  
Stuart J. Williams ◽  
Aloke Kumar ◽  
Steven T. Wereley
Keyword(s):  
Electrical Conductivity ◽  
Surface Modification ◽  
Particle Diameter ◽  
Lab On A Chip ◽  
Particle Manipulation ◽  
Complete Understanding ◽  
Heating Source ◽  
Electrokinetic Trapping ◽  
Rapid Electrokinetic Patterning ◽  
Optically Induced

Recently, we have demonstrated electrothermal hydrodynamics with an external heating source of a highly focused 1,064 nm laser beam [1]. This phenomenon, when coupled with particle-electrode electrokinetic interactions, has led to the rapid and selective concentration of suspended colloids [2–6]. This technique, termed Rapid Electrokinetic Patterning (REP) was demonstrated without any additional surface modification or patterning of the electrodes. This dynamic, optically induced fluid and particle manipulation technique could be used for a variety of lab-on-a-chip applications. However, there are additional effects that have yet to be investigated that are important for a complete understanding of REP. This paper showcases experimental particle-particle behavior observations by varying particle diameter, electrode material, and preliminary results of varying fluid electrical conductivity.

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