Visible-light driven regioselective synthesis of 1H-tetrazoles from aldehydes through isocyanide-based [3 + 2] cycloaddition

2018 ◽  
Vol 20 (16) ◽  
pp. 3783-3789 ◽  
Author(s):  
Fooleswar Verma ◽  
Anjumala Sahu ◽  
Puneet K. Singh ◽  
Ankita Rai ◽  
Manorama Singh ◽  
...  
Keyword(s):  
Visible Light ◽  
Sodium Azide ◽  
Regioselective Synthesis ◽  
Visible Light Driven

A novel and green Co@g-C3N4 catalyzed visible light driven direct regioselective synthesis of 1H-tetrazoles directly from various aldehydes and sodium azide is reported.

scholarly journals Visible-light driven regioselective synthesis, characterization and binding studies of 2-aroyl-3-methyl-6,7-dihydro-5H-thiazolo[3,2-a]pyrimidines with DNA and BSA using biophysical and computational techniques

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ranjana Aggarwal ◽  
Naman Jain ◽  
Shilpa Sharma ◽  
Prince Kumar ◽  
Gyan Prakash Dubey ◽  
...  
Keyword(s):  
Visible Light ◽  
2D Nmr ◽  
Docking Studies ◽  
New Drugs ◽  
Regioselective Synthesis ◽  
Computational Techniques ◽  
Binding Studies ◽  
Visible Light Driven ◽  
In Silico Toxicity ◽  
Displacement Assay

AbstractIn recent times, fused azaheterocycles emerged as impressive therapeutic agents. Binding studies of such azaheterocycles with biomolecules is an important subject for pharmaceutical and biochemical studies aiming at the design and development of new drugs. Fused heterocyclic scaffolds, such as thiazolopyrmidines have long been used in the pharmaceutical industry for the treatment of various diseases. In this study, we have accomplished a regioselective synthesis of 2-aroyl-3-methyl-6,7-dihydro-5H-thiazolo[3,2-a]pyrimidines by the reaction of tetrahydropyrimidine-2(H)-thione with α-bromo-1,3-diketones, generated in situ from 1,3-diketones and NBS, using visible light as an inexpensive, green and renewable energy source under mild reaction conditions with wide-ranging substrate scope. The regioisomer was characterized unambiguously by 2D-NMR [1H-13C] HMBC and [1H-13C] HMQC spectroscopy. In silico toxicity data analysis showed the low toxicity risks of the synthesized compounds. Computational molecular docking studies were carried out to examine the interaction of thiazolo[3,2-a]pyrimidines with calf-thymus DNA (ct-DNA) and Bovine Serum Albumin (BSA). Moreover, different spectroscopic approaches viz. steady-state fluorescence, competitive displacement assay, UV–visible and circular dichroism (CD) along with viscosity measurements were employed to investigate the binding mechanisms of thiazolo[3,2-a]pyrimidines with DNA and BSA. The results thus obtained revealed that thiazolo[3,2-a]pyrimidines offer groove bindings with DNA and showed moderate bindings with BSA.

Visible-light-driven copper-catalyzed aerobic oxidative cascade cyclization of N-tosylhydrazones and terminal alkynes: regioselective synthesis of 3-arylcoumarins

2019 ◽  
Vol 55 (35) ◽  
pp. 5151-5154 ◽  
Author(s):  
Ayyakkannu Ragupathi ◽  
Arunachalam Sagadevan ◽  
Vaibhav Pramod Charpe ◽  
Chun-Cheng Lin ◽  
Jih-Ru Hwu ◽  
...  
Keyword(s):  
Visible Light ◽  
Room Temperature ◽  
Regioselective Synthesis ◽  
Terminal Alkynes ◽  
Cascade Cyclization ◽  
Visible Light Driven

An intuitive visible-light-driven copper-catalyzed process can accomplish regioselective functionalized 3-arylcoumarins via oxidative annulation of simple N-tosylhydrazones with terminal alkynes under O2 (1 atm.) at room temperature.

Regioselective N1- and N2-heterocycloalkylation of N1-sulfonyl-1,2,3-triazoles

2020 ◽  
Vol 7 (22) ◽  
pp. 3727-3733
Author(s):  
Han Luo ◽  
Zongyuan Tang ◽  
Tao Wang ◽  
Yi Tian ◽  
Yuan Zhang ◽  
...  
Keyword(s):  
Visible Light ◽  
Regioselective Synthesis ◽  
Three Component Reaction ◽  
Visible Light Driven ◽  
Saturated Heterocycles

A tuneable and visible-light-driven three-component reaction between N1-sulfonyl-1,2,3-triazoles, saturated heterocycles, and N-bromosuccinimide for regioselective synthesis of N1- or N2-heterocycloalkylated 1,2,3-triazoles.

scholarly journals Rodlike AgI/Ag2Mo2O7 Heterojunctions with Enhanced Visible-Light-Driven Photocatalytic Activity

ACS Omega ◽  
2019 ◽  
Vol 4 (5) ◽  
pp. 7919-7930 ◽  
Author(s):  
Zhongyi Jiao ◽  
Zhendong Liu ◽  
Zhen Ma
Keyword(s):  
Photocatalytic Activity ◽  
Visible Light ◽  
Visible Light Driven

Construction of hollow In2S3/CdIn2S4 heterostructures with high efficiency for Cr(vi) reduction

2021 ◽  
Author(s):  
Cheng Cheng ◽  
Dongyun Chen ◽  
Najun Li ◽  
Hua Li ◽  
Qingfeng Xu ◽  
...  
Keyword(s):  
Visible Light ◽  
High Efficiency ◽  
Visible Light Driven

A hollow constructed photocatalyst, In2S3/CdIn2S4, was synthesized for visible-light-driven Cr(vi) reduction.

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