Evaluation of the anti-inflammatory properties of the active constituents in Ginkgo biloba for the treatment of pulmonary diseases

2019 ◽  
Vol 10 (4) ◽  
pp. 2209-2220 ◽  
Author(s):  
Zhu Tao ◽  
Wenwen Jin ◽  
Mingzhang Ao ◽  
Shengbing Zhai ◽  
Hang Xu ◽  
...  
Keyword(s):  
Ginkgo Biloba ◽  
Pulmonary Diseases ◽  
Mucus Hypersecretion ◽  
Active Constituents ◽  
Leukocyte Activity ◽  
Anti Inflammatory

Biflavones from G. biloba inhibit leukocyte activity and influence mucus hypersecretion as well as the secretion of IL-8.

scholarly journals Reduction of Pulmonary Inflammation by pH Modifiers

2022 ◽  
Author(s):  
Wei-ping Zeng
Keyword(s):  
Pulmonary Inflammation ◽  
Inflammatory Cells ◽  
Pathological Feature ◽  
Successful Therapy ◽  
Mucus Hypersecretion ◽  
Adverse Side Effects ◽  
New Class ◽  
Asthma Model ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Abstract Pulmonary inflammation is a common pathological feature of a variety of diseases, ofwhich successful therapy with currently available anti-inflammatory drugs is limited byresistance and adverse side effects. Using the ovalbumin-induced mouse allergic asthma model,the present study shows that treatments with pH modifiers, particularly simple acids such asacetate or hydrochloric acid, effectively depleted inflammatory cells in the lungs and blood aswell as hyperplastic lung tissue cells while preserving the structure of the blood vessels and lungparenchyma. The acid treatments also suppressed mucus hypersecretion. These resultsdemonstrated pH modifiers as a new class of broad-spectrum anti-inflammatory agents with antiproliferationand mucus suppression activities.

Hair-growth promoting effect and anti-inflammatory mechanism of Ginkgo biloba polysaccharides

2021 ◽  
pp. 118811
Author(s):  
Yingna Li ◽  
Wanwen Yu ◽  
Qingwen Cui ◽  
Jiuyue Liu ◽  
Xuechun Lu ◽  
...  
Keyword(s):  
Ginkgo Biloba ◽  
Hair Growth ◽  
Promoting Effect ◽  
Inflammatory Mechanism ◽  
Growth Promoting ◽  
Anti Inflammatory

Anti-inflammatory Active Constituents of Aloe arborescens Miller

1991 ◽  
Vol 55 (6) ◽  
pp. 1627-1629 ◽  
Author(s):  
Masatoshi Yamamoto ◽  
Toshio Masui ◽  
Kiyoshi Sugiyama ◽  
Masami Yokota ◽  
Kazuya Nakagomi ◽  
...  
Keyword(s):  
Active Constituents ◽  
Aloe Arborescens ◽  
Anti Inflammatory

Effectiveness of Ginkgo Biloba in Memory Disorders

1999 ◽  
Vol 12 (3) ◽  
pp. 217-224 ◽  
Author(s):  
Angela J. Massey
Keyword(s):  
Free Radicals ◽  
Ginkgo Biloba ◽  
Platelet Activating Factor ◽  
Memory Disorders ◽  
Bleeding Disorders ◽  
Active Constituents

Numerous trials have been conducted evaluating the efficacy of ginkgo biloba in memory disorders. The active constituents of ginkgo biloba are antioxidants that scavenge free radicals, which have been implicated in the pathogenesis of memory disorders. These studies suggest that ginkgo biloba in doses up to 120 mg/day when taken for 2 years may halt the progression of the disease for at least six months. The biggest concern of using ginkgo biloba is associated with its effects on platelet activating factor, which may result in bleeding disorders. Additional studies are needed to evaluate ginkgo biloba in combination with other medications.

scholarly journals Anti-inflammatory Active Constituents of Aloe arborescens Miller.

1991 ◽  
Vol 55 (6) ◽  
pp. 1627-1629 ◽  
Author(s):  
Masatoshi YAMAMOTO ◽  
Toshio MASUI ◽  
Kiyoshi SUOIYAMA ◽  
Masami YOKOTA ◽  
Kazuya NAKAGOMI ◽  
...  
Keyword(s):  
Active Constituents ◽  
Aloe Arborescens ◽  
Anti Inflammatory

scholarly journals Protective Effects of Ginkgo Biloba Dropping Pills Against Liver Ischemia/reperfusion Injury in Mice

2020 ◽  
Author(s):  
Zheng Wang ◽  
Ping Zhang ◽  
Qingqing Wang ◽  
Xueping Sheng ◽  
Jianbing Zhang ◽  
...  
Keyword(s):  
Cell Viability ◽  
Ginkgo Biloba ◽  
Ischemia Reperfusion ◽  
Protective Effects ◽  
Liver Ischemia ◽  
Primary Hepatocytes ◽  
Injury Model ◽  
Anti Inflammatory

Abstract Background: Liver ischemia-reperfusion (I/R) injury is an inevitable pathological phenomenon in various clinical conditions, such as liver transplantation, resection surgery, or shock, which is the major cause of morbidity and mortality after operation. Ginkgo Biloba Dropping Pill (GBDP) is a unique Chinese Ginkgo Biloba leaf extract preparation that exhibits a variety of beneficial biological activities. The aim of this study is to investigate the protective effects of GBDP on the liver I/R injury both in vitro and in vivo. Methods: Hypoxia/reoxygenation (H/R) experiments were performed in AML-12 cells and primary hepatocytes, which were pretreated with GBDP (60 or 120 μg/mL) followed by incubation in a hypoxia chamber. Cell viability and cell apoptosis were detected by MTT assay and annexin V staining respectively. C57BL/6 mice were used to establish liver I/R injury model, and were pretreated with GBDP (100 or 200 mg/kg/day, i.g.) for two weeks. Liver damage was detected by plasma levels of alanine transaminase (ALT) and aspartate transaminase (AST). Liver necrosis and neutrophil infiltration were determined by H&E and myeloperoxidase immunohistochemistry staining. Finally, TUNEL staining and western blot analysis of apoptosis-related proteins were used to investigate the anti-apoptotic effect of GBDP. Results: In the in vitro study, GBDP pretreatment improved the cell viability of AML-12 cells in H/R injury model. Similarly, the same result was found in the primary hepatocytes isolated from C57BL/6 mice. Moreover, GBDP decreased the number of apoptotic cells induced by H/R. In the in vivo study, oral administration of GBDP ameliorated liver injury evidenced by a significant decline in the levels of ALT and AST. Furthermore, the result of H&E staining showed that GBDP reduced the size of necrosis area. In addition, the decreased infiltration of neutrophils indicated that GBDP may play an anti-inflammatory effect. More importantly, GBDP reduced TUNEL-positive cells and the expression of Bax and caspase-3 in liver indicating GBDP has anti-apoptotic effects.Conclusion: Our findings elucidated that GBDP has potential effects for protecting against liver I/R injury characterized by its anti-apoptotic, anti-necrotic, and anti-inflammatory properties, which would promisingly make a contribution to the exploration of therapeutic strategies in the liver I/R injury.

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