A curcumin derivative, WZ35, suppresses hepatocellular cancer cell growthviadownregulating YAP-mediated autophagy

2019 ◽  
Vol 10 (6) ◽  
pp. 3748-3757 ◽  
Author(s):  
Lihua Wang ◽  
Zheng Zhu ◽  
Lei Han ◽  
Liqian Zhao ◽  
Jialei Weng ◽  
...  
Keyword(s):  
Cell Growth ◽  
Cancer Therapy ◽  
Liver Cancer ◽  
Hepatocellular Cancer ◽  
Cancer Type ◽  
Common Cancer ◽  
The World ◽  
Anti Tumor Activity ◽  
Common Cancer Type ◽  
Curcumin Derivative

HCC is a common cancer type in the world. Here, we found WZ35, a novel derivative of curcumin, could notably suppress HCC cell growthviainhibiting YAP controlled autophagy, highlighting the potent anti-tumor activity of WZ35 in liver cancer therapy.

scholarly journals Towards a Complete Pipeline for Segmenting Nuclei in Feulgen-Stained Images

2020 ◽  
Author(s):  
Luiz Antonio Buschetto Macarini ◽  
Aldo Von Wangenheim ◽  
Felipe Perozzo Daltoé ◽  
Alexandre Sherlley Casimiro Onofre ◽  
Fabiana Botelho de Miranda Onofre ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Early Detection ◽  
Morphological Alteration ◽  
Cancer Type ◽  
Post Processing ◽  
Nuclei Segmentation ◽  
Common Cancer ◽  
The World ◽  
Late Stages ◽  
Common Cancer Type

Cervical cancer is the second most common cancer type in womenaround the world. In some countries, due to non-existent or inadequatescreening, it is often detected at late stages, making standardtreatment options often absent or unaffordable. It is a deadlydisease that could benefit from early detection approaches. It isusually done by cytological exams which consist of visually inspectingthe nuclei searching for morphological alteration. Since itis done by humans, naturally, some subjectivity is introduced. Computationalmethods could be used to reduce this, where the firststage of the process would be the nuclei segmentation. In this context,we present a complete pipeline for the segmentation of nucleiin Feulgen-stained images using Convolutional Neural Networks.Here we show the entire process of segmentation, since the collectionof the samples, passing through pre-processing, training thenetwork, post-processing and results evaluation. We achieved anoverall IoU of 0.78, showing the affordability of the approach of nucleisegmentation on Feulgen-stained images. The code is availablein: https://github.com/luizbuschetto/feulgen_nuclei_segmentation

scholarly journals Vloga medijev pri ozaveščanju bolnikov z rakom

2015 ◽  
Vol 84 (5) ◽  
Author(s):  
Mirjana Rajer ◽  
Luka Čavka ◽  
Amela Duratović
Keyword(s):  
Cancer Patients ◽  
Information Needs ◽  
Medical Decision ◽  
Cancer Type ◽  
Huge Amount ◽  
Everyday Clinical Practice ◽  
Lung Cancer Patients ◽  
Common Cancer ◽  
Search For Information ◽  
Common Cancer Type

ABSTRACTBACKGROUNDNowadays cancer patients tend to be more involved in the medical decision process. Active participation improves health outcomes and patient satisfaction. To participate effectively patients require a huge amount of information, but time limits make it impossible to satisfy all information needs at clinics. We tried to find out which kind of media cancer patients use when searching for information and how often. Lastly, we try to find out how popular the Internet is in this regard.METODSIn this research we invited cancer patients, who had regular clinic examinations at the Oncology Institute between 21st and 25th May in 2012. We carried out a prospective research by anonymous questionnaires. We were investigating which media were used and how often. We analysed results with descriptive statistics, ANOVA, the χ²-Test and the t-test.RESULTS478 of 919 questionnaires distributed among cancer patients were returned. Mean age was 59.9 years. 61 % of responders were female, and the most common level of education was high school (33 %). Most common cancer type was breast cancer (33 %), followed by gastrointestinal and lung cancer. Patients search for information most often on television (81.4% responders), followed by specialized brochures (78%), internet (70.8%) and newspapers (67.6%). Patients who do not use media for information searching are older than average (62.5 years vs. 59.9 years; p<0,000).CONCLUSIONSAccording to our results patients search for information most often on television, followed by brochures, internet and newspapers. Older patients less often search for information. This data might help doctors in everyday clinical practice.

scholarly journals Analysis of the Most Viewed First 50 Videos on YouTube about Breast Cancer

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Isil Yurdaisik
Keyword(s):  
Breast Cancer ◽  
Healthcare Professionals ◽  
The Internet ◽  
Accurate Information ◽  
Cancer Type ◽  
Common Cancer ◽  
Health Related ◽  
The Mean ◽  
Common Cancer Type

Objective. Breast cancer is the most common cancer type among women worldwide. Today, health consumers search the Internet to gain health information about many diseases including breast cancer. YouTube™ is the second most commonly used website on the Internet. However, the quality and accuracy of health-related YouTube™ videos are controversial. The objective of this study was to investigate the quality and accuracy of breast cancer-related videos on YouTube™. Material and Methods. “Breast cancer” keyword was entered into YouTube™ search bar, and after excluding advertisement, duplicate, and non-English videos, the first most viewed 50 videos were analyzed. Videos’ length, the number of views, comments, likes, and dislikes were recorded. DISCERN and JAMA scores and Video Power Index (VPI) values of the videos were calculated. All videos were evaluated by two independent radiologists experienced on breast cancer. The correlation between the two observers was also analyzed. Results. Of all videos, 14% were uploaded by physicians, 26% by health channels, 20% by patients, 10% by news channels, 2% by herbalists, 2% by blog channels, and 2% by nonprofit activism channels. The mean DISCERN score was calculated as 26.70±10.99 and the mean JAMA score as 2.23±0.97. The mean VPI value, which was calculated to determine the popularity of the videos, was found as 94.10±4.48. A strong statistically significant correlation was found between the two observers in terms of both DISCERN and JAMA scores. There was an excellent agreement between the two observers. Conclusion. The overall quality of the viewed videos was found as poor. Healthcare professionals should be encouraged to upload breast cancer-related videos with accurate information to promote patients for screening and direct them appropriately.

Cannabinoids and cancer: potential for colorectal cancer therapy

2005 ◽  
Vol 33 (4) ◽  
pp. 712-714 ◽  
Author(s):  
H.A. Patsos ◽  
D.J. Hicks ◽  
A. Greenhough ◽  
A.C. Williams ◽  
C. Paraskeva
Keyword(s):  
Colorectal Cancer ◽  
Cell Growth ◽  
Cancer Therapy ◽  
Surgical Techniques ◽  
Chemotherapeutic Agents ◽  
Signalling Pathways ◽  
The World ◽  
Endogenous Cannabinoids ◽  
Tumour Cell Growth ◽  
Stimulation Of

Despite extensive research into the biology of CRC (colorectal cancer), and recent advances in surgical techniques and chemotherapy, CRC continues to be a major cause of death throughout the world. Therefore it is important to develop novel chemopreventive/chemotherapeutic agents for CRC. Cannabinoids are a class of compounds that are currently used in the treatment of chemotherapy-induced nausea and vomiting, and in the stimulation of appetite. However, there is accumulating evidence that they could also be useful for the inhibition of tumour cell growth by modulating key survival signalling pathways. The chemotherapeutic potential for plant-derived and endogenous cannabinoids in CRC therapy is reviewed.

Hepatocellular carcinoma: molecular interactions between hepatitis C virus and p53 in hepatocarcinogenesis

2003 ◽  
Vol 5 (28) ◽  
pp. 1-16 ◽  
Author(s):  
Mónica Anzola ◽  
Juan José Burgos
Keyword(s):  
Hepatocellular Carcinoma ◽  
Suppressor Gene ◽  
Tumour Suppressor Gene ◽  
Cancer Type ◽  
Crucial Importance ◽  
Hepatitis Viruses ◽  
Common Cancer ◽  
Correct Function ◽  
P53 Tumour Suppressor Gene ◽  
Common Cancer Type

Hepatocellular carcinoma (HCC) is the most important primary hepatic cancer and is a common cancer type worldwide. Many aetiological factors have been related to HCC development, such as liver cirrhosis, hepatitis viruses and alcohol consumption. Inactivation of the p53 tumour suppressor gene is one of the most common abnormalities in many tumours, including HCC. p53 is of crucial importance for the regulation of the cell cycle and the maintenance of genomic integrity. In HCC, hepatitis B and C virus (HBV and HCV) effect carcinogenic pathways, independently leading to anomalies in p53 function. Several authors have reported that some HCV proteins, such as the core, NS5A and NS3 proteins, interact with p53 and prevent its correct function. The mechanisms of action of these HCV proteins in relation to p53 are not completely clear, but they might cause its cytoplasmic retention or accumulation in the perinuclear region where the protein is not functional. The identification of the interactions between p53 and HCV proteins is of great importance for therapeutic strategies aimed at reducing the chronicity and/or carcinogenicity of the virus.

Up-Regulation of miR-1925 by Bone Marrow Mesenchymal Stem Cell (BMSC) Inhibits the Growth of Liver Cancer by Promoting the Anti-Tumor Activity of Natural Killer (NK) Cells

2022 ◽  
Vol 12 (3) ◽  
pp. 630-633
Author(s):  
Chencheng Ding ◽  
Yunjie Zheng ◽  
Dan Li ◽  
Min Zhu ◽  
Yong Zhu
Keyword(s):  
Bone Marrow ◽  
Cell Proliferation ◽  
Stem Cell ◽  
Cell Growth ◽  
Liver Cancer ◽  
Mesenchymal Stem Cell ◽  
Nk Cells ◽  
Liver Cancer Cell ◽  
Cancer Cell Growth ◽  
Anti Tumor Activity

Hepatocellular carcinoma (HCC) seriously threatens human health and life quality. Natural killer (NK) cells play important roles in liver immune function. Bone marrow mesenchymal stem cell (BMSC) exosomes (Exo) participate in tissue damage. This study explored BMSC-Exo’s effect on NK cells’ anti-tumor activity. NK cells were isolated from the livers of mice with liver cancer. NK cells with or without BMSC-Exo treatment were co-cultured with liver cancer cells to assess cell proliferation. Administration of BMSC-Exo into mice with liver cancer significantly suppressed liver cancer cell growth. In addition, BMSC-Exo treatment significantly improved NK cells’ anti-tumor effect whic was related to BMSC-Exo-induced up-regulation of miR-1925. Implantation of BMSC-Exo into mice with liver cancer at different time periods can significantly suppress liver cancer cell growth. At the same time, BMSC-Exo implantation inhibited the expression of cell proliferation marker protein(Ki67). In vitro study found that BMSC-Exo treatment significantly increased miR-1925 level and the toxicity of NK cells to HCC cells. In addition, miR-1925 overexpression in NK cells significantly increased NK cells’ anti-tumor activity. In conclusion, this study proved that up-regulation of miR-1925 by BMSC can inhibit the growth of liver cancer by promoting the anti-tumor activity of NK cells.

scholarly journals Targeting the Oncogenic p53 Mutants in Colorectal Cancer and Other Solid Tumors

2019 ◽  
Vol 20 (23) ◽  
pp. 5999 ◽  
Author(s):  
Hui Li ◽  
Jinglin Zhang ◽  
Joanna Hung Man Tong ◽  
Anthony Wing Hung Chan ◽  
Jun Yu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Solid Tumors ◽  
Tp53 Mutation ◽  
Tumor Development ◽  
Migration And Invasion ◽  
Cancer Type ◽  
Wild Type ◽  
Functional Roles ◽  
Common Cancer ◽  
Common Cancer Type

Colorectal cancer (CRC) is a kind of solid tumor and the third most common cancer type in the world. It is a heterogeneous disease characterized by genetic and epigenetic aberrations. The TP53 mutation is the key step driving the transition from adenoma to adenocarcinoma. The functional roles of TP53 mutation in tumor development have been comprehensively investigated. In CRC, TP53 mutation was associated with poor prognosis and chemoresistance. A gain of function (GOF) of p53 mutants promotes cell proliferation, migration and invasion through multiple mechanisms. Restoring wild type p53 function, depleting p53 mutants, or intervention by targeting the oncogenic downstreams provides potential therapeutic strategies. In this review, we comprehensively summarize the GOF of p53 mutants in CRC progression as well as in some other solid tumors, and discuss the current strategies targeting p53 mutants in malignancies.

scholarly journals Breast Cancer: Treatment Effects on Fertility and Subsequent Pregnancy Outcomes

2021 ◽  
Vol 8 (8) ◽  
pp. 442-447
Author(s):  
Antigoni Sarantaki ◽  
Kyriaki Perisaki
Keyword(s):  
Breast Cancer ◽  
Pregnancy Outcomes ◽  
Subsequent Pregnancy ◽  
Reproductive Age ◽  
Cancer Type ◽  
Women Of Reproductive Age ◽  
Breast Cancer Therapy ◽  
Common Cancer ◽  
Cancer Occurrence ◽  
Common Cancer Type

Objective: Breast cancer is the most common cancer type in women of reproductive age. Given that most women postpone childbearing, breast cancer occurrence possibly perplexes their plans for starting a family. The treatment for breast cancer can affect their fertility and have adverse effects on a pregnancy that occurs during that period. The aim of this narrative review is primarily to explore the influence of breast cancer therapy on the ability of a woman diagnosed with breast cancer to gestate. Moreover, to determine the safer timing for childbearing after being treated for breast cancer and investigate the pregnancy outcome when conception is succeeded. Childbearing after treatment for breast cancer is considered safe and pregnancy outcomes are favorable if conception happens 1 year after chemotherapy or at least 2 years after chemotherapy and radiation therapy. Counseling is of great significance and fertility preservation methods should be thoroughly discussed with women diagnosed with breast cancer, even prior to commencement of the treatment

scholarly journals Adiponectin accounts for gender differences in hepatocellular carcinoma incidence

2019 ◽  
Vol 216 (5) ◽  
pp. 1108-1119 ◽  
Author(s):  
Elisa Manieri ◽  
Leticia Herrera-Melle ◽  
Alfonso Mora ◽  
Antonia Tomás-Loba ◽  
Luis Leiva-Vega ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Adipose Tissue ◽  
Liver Cancer ◽  
Cancer Therapeutics ◽  
Cancer Development ◽  
Cancer Type ◽  
Cancer Cell Proliferation ◽  
Amp Activated Protein Kinase ◽  
Common Cancer Type ◽  
Insight Into

Hepatocellular carcinoma (HCC) is the sixth most common cancer type and the fourth leading cause of cancer-related death. This cancer appears with higher incidence in men and during obesity; however, the specific mechanisms underlying this correlation are unknown. Adipose tissue, a key organ in metabolic syndrome, shows evident gender disparities in the production of adipokines. Levels of the important adipokine adiponectin decrease in men during puberty, as well as in the obese state. Here, we show that this decrease in adiponectin levels is responsible for the increased liver cancer risk in males. We found that testosterone activates the protein JNK in mouse and human adipocytes. JNK-mediated inhibition of adiponectin secretion increases liver cancer cell proliferation, since adiponectin protects against liver cancer development through the activation of AMP-activated protein kinase (AMPK) and p38α. This study provides insight into adipose tissue to liver crosstalk and its gender relation during cancer development, having the potential to guide strategies for new cancer therapeutics.

Prevalence and Characteristics of Liver Cancer Patients in Immanuel Hospital Bandung within January 2013 until December 2014 Period

2016 ◽  
Vol 1 (4) ◽  
Author(s):  
Achmad R. Permadi ◽  
Hana Ratnawati ◽  
Teresa L. Wargasetia
Keyword(s):  
Liver Cancer ◽  
Cancer Patients ◽  
Medical Records ◽  
Clinical Symptoms ◽  
Data Retrieval ◽  
Common Cancer ◽  
Key Words Liver Cancer ◽  
Liver Cancer Patient ◽  
Right Lobe ◽  
The Right

Liver cancer is the fifth most common cancer in Indonesia. This research is to find out the prevalence and characteristics of liver cancer patients in Immanuel Hospital Bandung within the January 2013 until December 2014 period based on age, gender, clinical symptoms and predilections. This study was a descriptive verificative research with data retrieval of patients medical records that have been diagnosed with liver cancer that were hospitalized in Immanuel Hospital Bandung within January 2013 until December 2014 period. The study showed that the liver cancer patient prevalence in Immanuel Hospital Bandung within the period of January 2013 until December 2014 was 46 people. Characteristics of liver cancer patients in Immanuel Hospital Bandung within January 2013 until December 2014 period showed that the most liver cancer patients were male, compare with female with ratio 4:1, the most common age group of 56-65 years old, the most common clinical symptoms were abdominal pain with or without reffered pain to the right scapular bone and the most common predilection was right lobe of the liver. Key words: liver cancer, patients' characteristics, prevalence 

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